Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Shigeki, Shibahara"'
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150228 (2016)
Microphthalmia-associated transcription factor (Mitf) is a key regulator for differentiation of melanoblasts, precursors to melanocytes. The mouse homozygous for the black-eyed white (Mitfmi-bw) allele is characterized by the white-coat color and dea
Externí odkaz:
https://doaj.org/article/0b5d6790758a49968f018f1058b7b001
Autor:
Kazuhiro Takahashi, Shigeki Shibahara
Publikováno v:
The Tohoku Journal of Experimental Medicine. 250:1-3
Autor:
Kiriko Kaneko, Kazumichi Furuyama, Tohru Fujiwara, Ryoji Kobayashi, Hiroyuki Ishida, Hideo Harigae, Shigeki Shibahara
Publikováno v:
Haematologica, Vol 99, Iss 2 (2014)
Erythroid-specific 5-aminolevulinate synthase (ALAS2) is the rate-limiting enzyme for heme biosynthesis in erythroid cells, and a missense mutation of the ALAS2 gene is associated with congenital sideroblastic anemia. However, the gene responsible fo
Externí odkaz:
https://doaj.org/article/883222bbf2fd4d9b99ad8a9311e9b62d
Autor:
Daisuke Nishihara, Ichiro Yajima, Hiromasa Tabata, Masato Nakai, Nagaharu Tsukiji, Tatsuya Katahira, Kazuhisa Takeda, Shigeki Shibahara, Harukazu Nakamura, Hiroaki Yamamoto
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48879 (2012)
The retinal pigment epithelium (RPE) shares its developmental origin with the neural retina (NR). When RPE development is disrupted, cells in the presumptive RPE region abnormally differentiate into NR-like cells. Therefore, the prevention of NR diff
Externí odkaz:
https://doaj.org/article/b539f969ef2f410ca9612760506d461e
Publikováno v:
The Tohoku Journal of Experimental Medicine. 242:291-302
Cholangiocarcinoma represents the second most common primary liver tumor after hepatocellular carcinoma. Mahanine, a carbazole alkaloid derived from Murraya koenigii (Linn.) Spreng, has been used as folk medicine in Thailand, where the liver fluke-as
Autor:
Weerapon Sangartit, Wanida Donpunha, Poungrat Pakdeechote, Veerapol Kukongviriyapan, Upa Kukongviriyapan, Shigeki Shibahara
Publikováno v:
Vascular Pharmacology. 87:199-208
Excessive iron can generate reactive oxygen species (ROS), leading to oxidative stress that is closely associated with cardiovascular dysfunction. Iron overload was induced in male ICR mice by injection of iron sucrose (10mg/kg/day) for eight weeks.
Autor:
Hiroaki Yamamoto, Koji Ohba, Shigeki Shibahara, Takashi Suzuki, Kazuhisa Takeda, Shigeharu Wakana, Tamio Furuse, Tomohiro Suzuki
Publikováno v:
Genes to Cells. 21:1365-1379
Long interspersed element-1 (LINE-1) is a mammalian transposable element, and its genomic insertion could cause neurological disorders in humans. Incidentally, LINE-1 is present in intron 3 of the microphthalmia-associated transcription factor (Mitf)
Publikováno v:
The Tohoku journal of experimental medicine. 248(1)
Autor:
Papavee Samatiwat, Veerapol Kukongviriyapan, Koji Ohba, Shigeki Shibahara, Kazuhisa Takeda, Soisungwan Satarug
Publikováno v:
Biochemical and Biophysical Research Communications. 470:144-149
Microphthalmia-associated transcription factor (MITF) is a key regulator of differentiation of melanocytes and retinal pigment epithelial cells, but it also has functions in non-pigment cells. MITF consists of multiple isoforms, including widely expr
Autor:
Toshihiko Shiroishi, Koji Ohba, Kaoru Ichimura, Hirotoshi Shibuya, Shigeharu Wakana, Hiroaki Yamamoto, Hiroshi Tomita, Masaru Tamura, Kazuhisa Takeda, Shigeki Shibahara, Ryutaro Watanabe, Akiteru Maeno
Publikováno v:
Genesgenetic systems. 93(2)
Melanocytes develop from the vertebrate embryo-specific neural crest, migrate, and localize in various organs, including not only the skin but also several extracutaneous locations such as the heart, inner ear and choroid. Little is known about the f