Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shigekazu Shimizu"'
Autor:
Takeshi Watanabe, Satoshi Yasuda, Shinji Kusakawa, Takuya Kuroda, Hatsue Furukawa, Mayumi Futamura, Shigekazu Shimizu, Akihiko Morishita, Shinko Hata, Akiko Koeda, Kana Komatsu, Yoji Sato
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 315-323 (2024)
Introduction: MEASURE2 (Multisite Evaluation Study on Analytical Methods for Non-clinical Safety Assessment of HUman-derived REgenerative Medical Products 2) is a Japanese experimental public–private partnership initiative that aims to standardize
Externí odkaz:
https://doaj.org/article/912fe7017d9e4325ae16d6184b69c4af
Autor:
Seiji Hayashi, Yoshihide Kii, Mitsuyasu Tabo, Hitoshi Fukuda, Tetsuji Itoh, Takashi Shimosato, Hideto Amano, Mamoru Saito, Hajime Morimoto, Kiyoshi Yamada, Atsuhiro Kanda, Toshimasa Ishitsuka, Takanobu Yamazaki, Yoichi Kiuchi, Shinya Taniguchi, Tatsuya Mori, Shigekazu Shimizu, Yuji Tsurubuchi, Shun-ichi Yasuda, Shin-ichi Kitani, Chiaki Shimada, Kazuo Kobayashi, Masaharu Komeno, Chieko Kasai, Toshiyasu Hombo, Keiji Yamamoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 423-437 (2005)
To construct a non-clinical database for drug-induced QT interval prolongation, the electrophysiological effects of 11 positive and 10 negative compounds on action potentials (AP) in guinea-pig papillary muscles were investigated in a multi-site stud
Externí odkaz:
https://doaj.org/article/a0418258c79346d3ac043532653edbdc
Autor:
Yoshihide Kii, Seiji Hayashi, Mitsuyasu Tabo, Takashi Shimosato, Hitoshi Fukuda, Tetsuji Itoh, Hideto Amano, Mamoru Saito, Hajime Morimoto, Kiyoshi Yamada, Atsuhiro Kanda, Toshimasa Ishitsuka, Takanobu Yamazaki, Yoichi Kiuchi, Shinya Taniguchi, Tatsuya Mori, Shigekazu Shimizu, Yuji Tsurubuchi, Shun-ichi Yasuda, Shin-ichi Kitani, Chiaki Shimada, Kazuo Kobayashi, Masaharu Komeno, Chieko Kasai, Toshiyasu Hombo, Keiji Yamamoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 449-457 (2005)
Certain compounds that prolong QT interval in humans have little or no effect on action-potential (AP) duration used traditionally, but they inhibit rapidly-activated-delayed-rectifier potassium currents (IKr) and/or human ether-a-go-go-related gene
Externí odkaz:
https://doaj.org/article/607f605ce3e84d8090d1635dfe43b73c
Autor:
Daisuke Saji, Hiroyuki Ando, Takashi Kitaguchi, Takaaki Uda, Atsushi Toratani, Tomohiko Taniguchi, Wataru Yamamoto, Shigekazu Shimizu, Norimasa Miyamoto, Mahoko Asayama, Emi Matsumoto, Hiroyuki Saito, Koji Otabe, Yuta Moriyama, Masao Oguchi, Hiroki Ohnaka, Sanae Maeda
Publikováno v:
Journal of pharmacological and toxicological methods. 85
Introduction The use of multi-electrode arrays (MEA) in combination with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provides a promising method to predict comprehensive cardiotoxicity, including drug-induced QT prolongatio
Autor:
Yasuki Akie, Kunitoshi Mitsumori, Masayoshi Noguchi, Yoshihiko Kobayashi, Toshihito Kadota, Fumiyuki Nakane, Hirotoshi Akane, Masaki Kunieda, Akemi Saito, Shigekazu Shimizu
Publikováno v:
The Journal of Toxicological Sciences. 37:527-537
The 26-week oral toxicity of diheptyl phthalate (DHP), a peroxisome proliferator-activated receptor α (PPARα) agonist, with special emphasis on the potential induction of hepatocellular proliferative lesions was investigated in this study. DHP was
Publikováno v:
Rigakuryoho Kagaku. 25:419-425
〔目的〕本研究の目的は,機能的近赤外分光法(fNIRS)を使用し,後方観察による他者の視線方向の認知に関与する大脳皮質領域を調査することである。〔方法〕対象は健常成人7名とし
Effects of an Intent Inference Task on Mirror Neuron Activity during Action Observation -Using fNIRS
Publikováno v:
Rigakuryoho Kagaku. 24:191-199
[目的]近年,運動観察を用いた運動療法介入がミラーニューロン(MN)を賦活させ,運動機能回復に効果があるとする知見が報告されている。本研究の目的は,機能的近赤外分光法を
Autor:
Emi Matsumoto, Yuta Moriyama, Hiroyuki Saito, Shigekazu Shimizu, Koji Otabe, Masao Oguchi, Maya Morita, Kohji Tanaka, Atsuko Ojima, Ikumi Washio, Hiroki Ohnaka, Takaaki Uda, Takashi Kitaguchi, Atsushi Toratani, Mahoko Asayama, Tomohiko Taniguchi, Wataru Yamamoto, Norimasa Miyamoto, Hiroyuki Ando, Daisuke Saji
Publikováno v:
Journal of pharmacological and toxicological methods. 78
Introduction Drug-induced QT prolongation is a major safety issue during drug development because it may lead to lethal ventricular arrhythmias. In this study, we evaluated the utility of multi-electrode arrays (MEA) with human induced pluripotent st
Autor:
Kazuo Kobayashi, Hideto Amano, Tetsuji Itoh, Mamoru Saito, Yoshihide Kii, Shinya Taniguchi, Yoichi Kiuchi, Takashi Shimosato, Shun-ichi Yasuda, Chieko Kasai, Yuji Tsurubuchi, Toshimasa Ishitsuka, Tatsuya Mori, Seiji Hayashi, Kiyoshi Yamada, Mitsuyasu Tabo, Hajime Morimoto, Chiaki Shimada, Hitoshi Fukuda, Shin-ichi Kitani, Atsuhiro Kanda, Keiji Yamamoto, Toshiyasu Hombo, Masaharu Komeno, Takanobu Yamazaki, Shigekazu Shimizu
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 423-437 (2005)
To construct a non-clinical database for drug-induced QT interval prolongation, the electrophysiological effects of 11 positive and 10 negative compounds on action potentials (AP) in guinea-pig papillary muscles were investigated in a multi-site stud
Autor:
Shigekazu Shimizu, Hiroyuki Saito, Koji Otabe, Masao Oguchi, Emi Matsumoto, Hiroki Ohnaka, Tomohiko Taniguchi, Yuta Moriyama, Ikumi Washio, Maya Morita, Masakazu Ishimura, Mahoko Asayama, Daisuke Saji, Takashi Kitaguchi, Wataru Yamamoto, Takaaki Uda, Norimasa Miyamoto, Atsuko Ojima, Atsushi Toratani, Hiroyuki Ando
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 81:384-385