Výsledky vyhledávání - "Shigekazu NAGATA"

Akademický článek

Cloning of human Type I interferon cDNAs

Autor: Shigekazu NAGATA

Publikováno v: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, Vol 100, Iss 1, Pp 1-14 (2023)

In the late 1970s, crude interferon samples were found to exhibit anti-tumour activity. This discovery led to the interferon as a “magic drug” for cancer patients. Many groups, including those in Tokyo, Zurich, and San Francisco, attempted to ide

Externí odkaz: https://doaj.org/article/2827b54a5236447a83e3f886dae48f91

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Akademický článek

Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation

Autor: Satoshi Omori, Misato Tsugita, Yasuto Hoshikawa, Masanobu Morita, Fumiya Ito, Shin-Ichiro Yamaguchi, Qilin Xie, Osamu Noyori, Tomoya Yamaguchi, Ayato Takada, Tatsuya Saitoh, Shinya Toyokuni, Hisaya Akiba, Shigekazu Nagata, Kengo Kinoshita, Masafumi Nakayama

Publikováno v: Cell Reports, Vol 34, Iss 6, Pp 108734- (2021)

Summary: Macrophage recognition and phagocytosis of crystals is critical for the associated fibrosis and cancer. Of note, multi-walled carbon nanotubes (MWCNTs), the highly representative products of nanotechnology, induce macrophage NLRP3 inflammaso

Externí odkaz: https://doaj.org/article/c7b014b102d843bda38a9296ef0a0636

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Akademický článek

Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells

Autor: Hiroshi Yamaguchi, Toshihiko Maruyama, Yoshihiro Urade, Shigekazu Nagata

Publikováno v: eLife, Vol 3 (2014)

Apoptosis is coupled with recruitment of macrophages for engulfment of dead cells, and with compensatory proliferation of neighboring cells. Yet, this death process is silent, and it does not cause inflammation. The molecular mechanisms underlying an

Externí odkaz: https://doaj.org/article/d3a48e7cf1084ea0a64c41b61ca76108

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Akademický článek

Biogenesis and proteolytic processing of lysosomal DNase II.

Autor: Susumu Ohkouchi, Masahiro Shibata, Mitsuho Sasaki, Masato Koike, Paul Safig, Christoph Peters, Shigekazu Nagata, Yasuo Uchiyama

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59148 (2013)

Deoxyribonuclease II (DNase II) is a key enzyme in the phagocytic digestion of DNA from apoptotic nuclei. To understand the molecular properties of DNase II, particularly the processing, we prepared a polyclonal antibody against carboxyl-terminal seq

Externí odkaz: https://doaj.org/article/2b635b76b46a458cba798c9271b52792

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Akademický článek

Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif.

Autor: Xi Liu, Teruyuki Sano, Yongsheng Guan, Shigekazu Nagata, Jules A Hoffmann, Hidehiro Fukuyama

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42725 (2012)

Innate immune responses against DNA are essential to counter both pathogen infections and tissue damages. Mammalian EYAs were recently shown to play a role in regulating the innate immune responses against DNA. Here, we demonstrate that the unique Dr

Externí odkaz: https://doaj.org/article/398f6804122a4533a9832b05fc60df37

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