Výsledky vyhledávání - "Shigekazu Fujita"

New Approach to Drug Discovery of a Safe Mitochondrial Uncoupler: OPC-163493

Autor: Motohiro Itotani, Hitomi Minoshima, Naohide Kanemoto, Shigekazu Fujita, Satoshi Matsuda, Takashi Ban, Seiji Sato, Takashi Okamoto, Takahiro Shimada, Toshio Shinohara, Chiharu Matsumura

Publikováno v: ACS Omega, Vol 6, Iss 26, Pp 16980-16988 (2021)
ACS Omega

We serendipitously found a mitochondrial uncoupler (mUncoupler), compound 1, in the process of screening for inhibitors of a gene product related to calorie restriction (CR) and longevity. Compound 1 has a unique 4-cyano-1,2,3-triazole structure whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabc329cc8c21b81215b4e8f492367fa
https://doaj.org/article/eb415dadc2c94e299aed0c67c5cdc4e6

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Enantioselective Pummerer-type rearrangement by reaction of O-silylated ketene acetal with enantiopure α-substituted sulfoxides

Autor: Yasuyuki Kita, Masahiko Bando, Shigekazu Fujita, Norio Shibata, Seiji Fukui

Publikováno v: Scopus-Elsevier

Chiral non-racemic α-substituted sulfoxides have been allowed to react with O-silylated ketene acetals in the presence of a catalytic amount of ZnI2 in THF to give chiral non-racemic α-siloxy sulfides in >99% ee. This is the highest enantioselectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb6218d6a600504fb0aab5876f9450e
https://doi.org/10.1039/a702020a

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Usefulness of PRESTO magnetic resonance imaging for the differentiation of schwannoma and meningioma in the cerebellopontine angle

Autor: Yuki Wakata, Kumiko Ando, Manabu Shirakawa, Norio Arita, Yusuke Tomogane, Keizo Kaba, Shigekazu Fujita, Kanji Mori, Reiichi Ishikura, Shuichi Izumoto

Publikováno v: Neurologia medico-chirurgica. 53(7)

The principles of echo-shifting with a train of observations (PRESTO) magnetic resonance (MR) imaging technique employs an MR sequence that sensitively detects susceptibility changes in the brain. The effectiveness of PRESTO MR imaging was examined f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cec3db1ef4f650f33ef43ead5be8da
https://pubmed.ncbi.nlm.nih.gov/23883559

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An Intramolecular Cyclization of Phenol Derivatives Bearing Aminoquinones Using a Hypervalent Iodine Reagent

Autor: Shigekazu Fujita, Michiyo Gyoten, Yasuyuki Kita, Hirofumi Tohma, Megumi Ibaraki, Sachiko Mihara, Takeshi Takada

Publikováno v: The Journal of Organic Chemistry. 61:223-227

The hypervalent iodine oxidation of phenol derivatives bearing aminoquinones at the ortho (9) or meta positions (19) in 2,2,2-trifluoroethanol was investigated with the aim of preparing novel antitumor compounds. Azacarbocyclic spirodienone derivativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f9b4acafc021ece203bb714a6eb9057
https://doi.org/10.1021/jo951439q

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A novel diastereoselective synthesis of chiral, non-racemic unsymmetrical thioacetals using silicon-induced Pummerer-type reaction

Autor: Norio Shibata, Kouzou Matsumoto, Shigekazu Fujita, Yasuyuki Kita, Michiyo Gyoten

Publikováno v: Tetrahedron Letters. 36:109-112

Chiral, non-racemic sulfoxides were reacted with thiols and BSA in the presence of a catalytic amount of TMSOTf in MeCN at rt overnight to give the corresponding chiral, non-racemic anti-thioacetals with high diastereoselectivity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12f6c45ff34b20ce1fd0ba66d92868f1
https://doi.org/10.1016/0040-4039(94)02178-e

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Spontaneous regression of pulmonary involvement after smoking reduction and removal of and radiation therapy for Langerhans cell histiocytosis of the sphenoid bone: which comes first, the chicken or the egg?

Autor: Norio Arita, Hiroyasu Ogawa, Ruri Kato, Hiroya Tamaki, Shigekazu Fujita, Seiichi Hirota, Yoshitane Tsukamoto

Publikováno v: Internal medicine (Tokyo, Japan). 51(5)

Isolated pulmonary Langerhans cell histiocytosis (LCH) in adults is known to regress spontaneously after smoking cessation alone, but little is known about whether this rationale could also apply in cases of multisystem pulmonary LCH. In particular,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dea9896f0be9a9523416b5868c2aaae
https://pubmed.ncbi.nlm.nih.gov/22382566

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