Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shigehiro Takahama"'
Autor:
Tsutomu Mochizuki, Ruediger Nave, Shiro Kondo, Hideyuki Sato, Shigehiro Takahama, Takashi Nonaka
Publikováno v:
Biopharmaceutics & Drug Disposition. 28:59-64
Ciclesonide, a new corticosteroid for allergic rhinitis, is administered as an inactive parent compound that is converted by esterases to the pharmacologically active metabolite, desisobutyryl-ciclesonide (des-CIC). This study investigated the in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9065147aa2c219f3129508c367881439
https://doi.org/10.1002/bdd.531
https://doi.org/10.1002/bdd.531
Autor:
Ruediger Nave, Tsutomu Mochizuki, Takashi Nonaka, Hideyuki Sato, Shiro Kondo, Shigehiro Takahama
Publikováno v:
Biopharmaceutics & Drug Disposition. 28:43-50
Ciclesonide, a corticosteroid in development for allergic rhinitis, is converted to the pharmacologically active metabolite, desisobutyryl-ciclesonide (des-CIC), and des-CIC is subsequently esterified with fatty acids. Various experiments were perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ef3ace492292f36c4d9a23f586623d
https://doi.org/10.1002/bdd.529
https://doi.org/10.1002/bdd.529
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 575:63-67
A sensitive and specific method using gas chromatography and negative-ion chemical ionization mass spectrometry is described for the determination of 5-fluoro-2'-deoxyuridine (FdUrd) in plasma. The method is based on the formation of the pentafluorop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c104c8357b479f4d28840eadf445fd1f
https://doi.org/10.1016/0378-4347(92)80504-j
https://doi.org/10.1016/0378-4347(92)80504-j
Autor:
Nishibe Yoshihisa, Mark A. Wingertzahn, Shiro Kondo, Ruediger Nave, Hideyuki Sato, Tsutomu Mochizuki, Takashi Nonaka, Nagano Atsuhiro, Shigehiro Takahama
Publikováno v:
BMC Pharmacology
Background The nasal tissue uptake and metabolism of ciclesonide, a new-generation corticosteroid under investigation for treatment of allergic rhinitis, to its active metabolite, desisobutyryl-ciclesonide (des-CIC), was evaluated when administered t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324871509b491705d2fd8358a36aea03
https://doi.org/10.1186/1471-2210-7-7
https://doi.org/10.1186/1471-2210-7-7
Publikováno v:
Journal of immunoassay. 13(2)
A sensitive and specific radioimmunoassay for a new anti-ulcer drug TG-51 has been developed and applied to the evaluation of its pharmacokinetics in humans. The antiserum was raised in rabbits against an immunogen of N-Acetyl-TG-51 coupled to human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a09dfce7e756249e189ecca9d6259ae
https://pubmed.ncbi.nlm.nih.gov/1430238
https://pubmed.ncbi.nlm.nih.gov/1430238
Autor:
Shigehiro Takahama, Hitoshi Ohmori
Publikováno v:
Agricultural and Biological Chemistry. 53:209-213
We report the essential role of lipid in the development of a serum-free culture medium that supports the primary antibody response by murine lymphocytes in vitro. In our preceding paper, we have reported that β-cyclodextrin (β-CD) is effective as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aeefd486ea1f575aa8965390b6792c5
https://doi.org/10.1271/bbb1961.53.209
https://doi.org/10.1271/bbb1961.53.209
Autor:
Toru Takeshita, Kenji Hoshina, Tatsuyuki Naruchi, Shigehiro Takahama, Yorimasa Suwa, Noboru Yamazaki
Publikováno v:
General pharmacology. 19(4)
1. 1. Effect of TEI-5103 on the levels of various prostaglandins (PG's) in rat gastric mucosa was studied by HPLC and RIA methods. 2. 2. When administrated in vivo , TEI-5103 significantly increased the level of prostaglandin E 2 (PGE 2 ) but only sl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e722e25a2e5d28a38768b1e622d8e50b
https://pubmed.ncbi.nlm.nih.gov/3165898
https://pubmed.ncbi.nlm.nih.gov/3165898