Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Shigehiro Asano"'
Autor:
Eiki Akagawa, Katsuhisa Tanaka, Sayuri Takemoto, Kaoru Sato, Sachie Watanabe, Satomi Watanabe, Nobuyuki Nagao, Misato Ohtani, Shigehiro Asano, Eisuke Tatsumi, Yoshihiro Miyaoto
Publikováno v:
Journal of Hypertension. 41:e499-e500
Autor:
Kaoru Sato, Sachie Watanabe, Nobuyuki Nagao, Sayuri Takemoto, Satomi Watanabe, Nao Kawabata, Miku Masuzaki, Misato Ohtani, Katsuhisa Tanaka, Eiki Akagawa, Shigehiro Asano, Yoshihiro Miyamoto
Publikováno v:
Journal of Hypertension. 41:e498-e499
Autor:
James T. Patterson, Henry D. Wilson, Christoph Rader, Carlos F. Barbas, Napon Nilchan, Roberta P. Fuller, William R. Roush, Shigehiro Asano
Publikováno v:
Bioconjugate Chemistry. 27:2271-2275
Bioorthogonal labeling of antibodies enables the conjugation of compounds, such as small molecules or peptides, which expand targeting capacity or enhance cytotoxicity. Taking advantage of a cyclohexene sulfonamide compound that site-selectively labe
Publikováno v:
Angewandte Chemie International Edition. 53:11783-11786
Conjugation to human serum albumin (HSA) has emerged as a powerful approach for extending the in vivo half-life of many small molecule and peptide/protein drugs. Current HSA conjugation strategies, however, can often yield heterogeneous mixtures with
Publikováno v:
ACS Medicinal Chemistry Letters. 5:133-137
CCR5 antagonists are among the most advanced approaches in HIV therapy and may also be relevant to treatment of graft-versus-host disease and Staphylococcus aureus infection. To expand the potential of the only approved CCR5 antagonist, Maraviroc, we
Publikováno v:
Angewandte Chemie. 125:12824-12828
Cysteine-maleimide chemistry is widely used for peptide and protein modification. However, the formed succinimide linkage is readily hydrolyzed and is susceptible to an exchange reaction in vivo. We demonstrate that methylsulfonyl phenyloxadiazole co
Autor:
Shogo Nakatani, Shigehiro Asano, Erina Koga, Yoshiaki Isobe, Nobuyuki Koike, Masafumi Komiya, Junetsu Igarashi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 61:1094-1097
Based on the structure activity relationship of 2-(4-phenoxybenzoyl)-5-hydroxyindole (1), a novel structural class of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibitors were synthesized. We show in this study that the acidic proton at
Publikováno v:
Tetrahedron. 68:272-279
2 /S-Phos abstract SuzukieMiyaura cross-coupling reaction with 2-heteroarylboronic acids is generally challenging due to these acids easy decomposition. To overcome this problem, we developed a coupling method that uses 2- heteroaryl pinacol boronate
Autor:
Hwa-Joon Oh, A. Hatakeyama, VanDung Dang To, N. Yano, Brad W. Michael, Gilles Gervais, Brian Flachs, Daniel Alan Brokenshire, Jentje Leenstra, John S. Liberty, Peichun Liu, T. Le, E. Iwata, O. Takahashi, Silvia Melitta Mueller, Mohammad Peyravian, Shigehiro Asano, Sang Hoo Dhong, Yukio Watanabe, Roy Moonseuk Kim, Harm Peter Hofstee
Publikováno v:
IEEE Journal of Solid-State Circuits. 41:63-70
This paper describes an 11 FO4 streaming data processor in the IBM 90-nm SOI-low-k process. The dual-issue, four-way SIMD processor emphasizes achievable performance per area and power. Software controls most aspects of data movement and instruction
Autor:
Kazuo Eiho, Hideyuki Tomizawa, Yoshiaki Isobe, Masamitsu Aoki, Mai Kasai, Manabu Watanabe, Shigehiro Asano
Toll-like receptors (TLRs) play important roles in the innate immune system. In fact, recognition of endogenous immune complexes containing self-nucleic acids as pathogen- or damage-associated molecular patterns contributes to certain autoimmune dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b96b03b440756e59bc7fc973ddab5e0
https://europepmc.org/articles/PMC4233361/
https://europepmc.org/articles/PMC4233361/