Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Shigehiro, Ohdo"'
Autor:
Tomoaki Yamauchi, Yumi Okano, Daishu Terada, Sai Yasukochi, Akito Tsuruta, Yuya Tsurudome, Kentaro Ushijima, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Background The metabolic reprogramming of amino acids is critical for cancer cell growth and survival. Notably, intracellular accumulation of cysteine is often observed in various cancers, suggesting its potential role in alleviating the oxi
Externí odkaz:
https://doaj.org/article/35e7c01729b441ca91a5479265cb9b38
Autor:
Takeshi Wakasa, Kentaro Nonaka, Akihito Harada, Yasuyuki Ohkawa, Chie Kikutake, Mikita Suyama, Takashi Kobunai, Kenta Tsunekuni, Kazuaki Matsuoka, Yuki Kataoka, Hiroaki Ochiiwa, Kazutaka Miyadera, Takeshi Sagara, Eiji Oki, Shigehiro Ohdo, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract The fluorinated thymidine analog trifluridine (FTD) is a chemotherapeutic drug commonly used to treat cancer; however, the mechanism by which FTD induces cytotoxicity is not fully understood. In addition, the effect of gain-of-function (GOF)
Externí odkaz:
https://doaj.org/article/d0e4286119c6423db3d09770e905d4cc
Publikováno v:
Allergology International, Vol 71, Iss 4, Pp 437-447 (2022)
Clock genes, circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN), control various circadian rhythms in many biological processes such as physiology and behavior. Clock gene regulates many diseases such as cancer, immunological dysf
Externí odkaz:
https://doaj.org/article/04c4371956364c74b08c415d51178f00
Autor:
Yuya Yoshida, Naoya Matsunaga, Takaharu Nakao, Kengo Hamamura, Hideaki Kondo, Tomomi Ide, Hiroyuki Tsutsui, Akito Tsuruta, Masayuki Kurogi, Michio Nakaya, Hitoshi Kurose, Satoru Koyanagi, Shigehiro Ohdo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Alteration of circadian rhythms is often observed in patients with chronic kidney disease (CKD). Here, the authors show that CKD-induced dysfunction of the circadian clock increases the expression of G protein-coupled receptor 68 in circulating monoc
Externí odkaz:
https://doaj.org/article/003803f8997a470c8148526aae949ed1
Autor:
Mizuki Kato, Yuya Tsurudome, Takumi Kanemitsu, Sai Yasukochi, Yuki Kanado, Takashi Ogino, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract The expression and function of some xenobiotic transporters varies according to the time of day, causing the dosing time-dependent changes in drug disposition and toxicity. Multidrug resistance-associated protein-4 (MRP4), an ATPbinding ca
Externí odkaz:
https://doaj.org/article/44bf9c4e2baa4bbdb723542927ad3ac6
Autor:
Ken-ichi Hashikawa, Akito Tsuruta, Wakaba Yamakawa, Sai Yasukochi, Satoru Koyanagi, Shigehiro Ohdo
Publikováno v:
Biochemical and Biophysical Research Communications. 658:88-96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::370fb11f54dcfdd0592597329dd6e8e5
https://doi.org/10.1016/j.bbrc.2023.03.070
https://doi.org/10.1016/j.bbrc.2023.03.070
Autor:
Takashi Ogino, Naoya Matsunaga, Takahiro Tanaka, Tomohito Tanihara, Hideki Terajima, Hikari Yoshitane, Yoshitaka Fukada, Akito Tsuruta, Satoru Koyanagi, Shigehiro Ohdo
Publikováno v:
eLife, Vol 10 (2021)
Disruption of the circadian clock machinery in cancer cells is implicated in tumor malignancy. Studies on cancer therapy reveal the presence of heterogeneous cells, including breast cancer stem-like cells (BCSCs), in breast tumors. BCSCs are often ch
Externí odkaz:
https://doaj.org/article/c73d43d82c3a44c2829ec54f75f53fd7
Autor:
Shohei Uchinomiya, Tomoki Nagaura, Mark Weber, Yuya Matsuo, Naoki Zenmyo, Yuya Yoshida, Akito Tsuruta, Satoru Koyanagi, Shigehiro Ohdo, Naoya Matsunaga, Akio Ojida
Publikováno v:
Journal of the American Chemical Society. 145:8248-8260
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9649c4fbe24b74001f739bfeaf9b293f
https://doi.org/10.1021/jacs.3c02043
https://doi.org/10.1021/jacs.3c02043
Publikováno v:
Journal of Pharmacological Sciences, Vol 136, Iss 4, Pp 228-233 (2018)
Proliferation of acute lymphoblastic leukemic cells is nutritionally dependent on the external supply of asparagine. l-asparaginase, an enzyme hydrolyzing l-asparagine in blood, is used for treatment of acute lymphoblastic leukemic and other related
Externí odkaz:
https://doaj.org/article/20f550613df044a886531eba11edfbfb
Publikováno v:
Journal of Pharmacological Sciences, Vol 134, Iss 4, Pp 211-217 (2017)
Maintenance of circadian rhythms is essential to many aspects of human health, including metabolism and neurological and psychiatric well-being. Chronic disruption of circadian clock function is implicated in increasing the risk of metabolic syndrome
Externí odkaz:
https://doaj.org/article/0cc4997c018e4c8f87f56277bbcfd7e1