Výsledky vyhledávání - "Shigehiko Mukai"

Cross-Presentation of Tumor Antigens to Effector T Cells Is Sufficient to Mediate Effective Immunotherapy of Established Intracranial Tumors

Autor: Gregory E. Plautz, Shigehiko Mukai, Peter A. Cohen, Suyu Shu

Publikováno v: The Journal of Immunology. 165:3656-3662

The systemic adoptive transfer of tumor-sensitized T cells, activated ex vivo, can eliminate established intracranial tumors. Regression of MHC class II negative MCA 205 fibrosarcomas occurs optimally following adoptive transfer of both CD4 and CD8 t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48e605d9b2c8d89eaf7c20926fb3b53
https://doi.org/10.4049/jimmunol.165.7.3656

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Inhibition of Human Lung Cancer Cell Growth by the Peroxisome Proliferator-Activated Receptor-γ Agonists through Induction of Apoptosis

Autor: Yasunori Tsubouchi, Yutaka Kawahito, Ryoji Yamada, Motoharu Kondo, Hajime Sano, Timothy Hla, Shigehiko Mukai, Masataka Kohno, Ken-ichiro Inoue

Publikováno v: Biochemical and Biophysical Research Communications. 270:400-405

Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptors superfamily, have an important regulatory role in adipogenesis and inflammation. PPAR-gamma ligands induce terminal differentiation and growth inhibition of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ccdb4179191e2a5709953bf4d2e620
https://doi.org/10.1006/bbrc.2000.2436

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PSK and OK-432-Induced Immunomodulation of Inducible Nitric Oxide (NO) Synthase Gene Expression in Mouse Peritoneal Polymorphonuclear Leukocytes and NO-Mediated Cytotoxicity

Autor: Shigeru Sugino, Shigeru Kimura, Motoharu Kondo, Kiyoshi Asai, Haruki Kato, Shigehiko Mukai, Keiko Akaogi, Yoshiharu Yamamura, Mamoru Inoue, Toshikazu Yoshikawa, Hajime Sano, Kunitaka Hirose

Publikováno v: Immunopharmacology and Immunotoxicology. 22:221-235

We investigated whether PSK (a polysaccharide from the mycelia of Coriolus versicolor) or OK-432 (a streptococcal preparation) can up-regulate inducible nitric oxide synthase (iNOS) gene expression and nitric oxide (NO) production in mouse peritoneal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d2a04b6c59a2ae643bd2033e84ed37
https://doi.org/10.3109/08923970009016417

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Morphological study of cytotoxicity produced by PSK-induced polymorphonuclear leukocytes (PMNs) andNocardia rubra cell wall skeleton

Autor: Kiyoshi Asai, Yoshiharu Yamamura, Mamoru Inoue, Hajime Sano, Akira Hashiramoto, Shigeru Sugino, Shigeru Kimura, Tadaaki Yoshida, Shigehiko Mukai, Yutaka Kawahito, Motoharu Kondo, Haruki Kato

Publikováno v: Biotherapy. 9:229-239

The morphologic changes in PMNs induced by an i.p. injection of PSK, a polysaccharide from the mycelia of Coriolus versicolor, and tumor cells undergoing cell death, were evaluated by immunohistochemical staining and electron microscopy. Male C3H/He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fb04bfee59cd7381607f17910fff1f
https://doi.org/10.1007/bf02620736

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The expression of cyclooxygenase 1 and 2 in the snovium of patients with rheumatoid arthritis

Autor: Shigeru Kimura, Kiyoshi Asai, Motoharu Kondo, Yoshiaki Kusaka, Yutaka Kawahito, Shigehiko Mukai, Haruki Kato, Hajime Sano

Publikováno v: Ensho. 15:241-247

Cyclooxygenase (COX), or prostaglandin (PG) H synthase, is the first exzyme of the pathway in which arachidonic acid is oxidized to PGs. We previously reported that high levels of immunoreactive COX were present in synovia from patients with rheumato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c79ae835d01e36857c84ae4011dc6986
https://doi.org/10.2492/jsir1981.15.241

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Tyrosine phosphorylation in the synovium of patients with rheumatoid arthritis and rats with experimental arthritis

Autor: Kiyoshi Asai, Motoharu Kondo, Yutaka Kawahito, Shigeru Kimura, Shigehiko Mukai, Ronald L. Wilder, Hajime Sano, Haruki Kato

Publikováno v: Japanese Journal of Clinical Immunology. 17:525-533

慢性関節リウマチ(RA)の病態は,滑膜の腫瘍性増殖による骨・軟骨破壊である. RAの滑膜ではfibroblast growth factor (FGF)-1やplatelet-derived growth factor(PDGF)などの増殖因子やPDGFレセプター(α, β)の発�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9db85069d124d59772c8c0b08dc997ac
https://doi.org/10.2177/jsci.17.525

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Recombinant human granulocyte colony-stimulating factor augments cytotoxicity of OK-432-induced polymorphonuclear leukocytes

Autor: Kiyoshi Asai, Motoharu Kondo, Yoshiharu Yamamura, Haruki Kato, Shigeru Sugino, Shigeru Kimura, Yutaka Kawahito, Shigehiko Mukai, Mamoru Inoue, Hajime Sano

Publikováno v: International Journal of Immunopharmacology. 16:19-28

Polymorphonuclear leukocytes (PMNs) recovered from the peritoneal cavity of mice treated with the streptococcal preparation OK-432, exhibited strong cytotoxicity after the in vitro addition of Nocardia rubra cell wall skeleton (N-CWS). In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531f0858c3471722bb59275cff14a473
https://doi.org/10.1016/0192-0561(94)90115-5

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Elevated tissue concentrations of sialyl lex-i in cancerous tissues compared with those in noncancerous tissues of various organs

Autor: Motoharu Kondo, Yuji Naito, Tsuneaki Ohtsuki, Hirofumi Yamamoto, Mitsuya Matsuba, Toshikazu Yoshikawa, Shigehiko Mukai, Koichi Nishida

Publikováno v: Cancer. 68:111-117

Sialyl Lex-i (SLX) concentrations in the extracts of noncancerous and cancerous tissues of various human organs were determined by radioimmunoassay for detailed evaluation of SLX. Cancerous tissues had significantly elevated SLX concentrations compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82fe2e94a3099d774dcf07c5b2539fc7
https://doi.org/10.1002/1097-0142(19910701)68:1<111::aid-cncr2820680122>3.0.co

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T cell-mediated tumor rejection displays diverse dependence upon perforin and IFN-gamma mechanisms that cannot be predicted from in vitro T cell characteristics

Autor: Liaomin Peng, Shigehiko Mukai, Gregory E. Plautz, Suyu Shu, Peter A. Cohen, John C. Krauss

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 165(12)

Experimental pulmonary metastases have been successfully treated by adoptive transfer of tumor-sensitized T cells from perforin knockout (KO) or Fas/APO-1 ligandKO mice, suggesting a prominent role for secretion of cytokines such as IFN-γ. In the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f7b3e27bdc3c979028f1d4372fe2b8
https://pubmed.ncbi.nlm.nih.gov/11120842

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Selective inhibition of cyclooxygenase-2 with antisense oligodeoxynucleotide restricts induction of rat adjuvant-induced arthritis

Autor: Yutaka Kawahito, Akira Hashiramoto, Yasunori Tsubouchi, Miki Inoue, Timothy Hla, Akiko Komatsu, Ryoji Yamada, Shigehiko Mukai, Ken-ichiro Inoue, Hajime Sano, Masataka Kohno, Motoharu Kondo

Publikováno v: Biochemical and biophysical research communications. 269(2)

The effects of cyclooxygenase (COX)-2 antisense oligodeoxynucleotide (ODN) in induction of adjuvant-induced arthritis were investigated. Female Lewis rats were injected with Mycobacterium butyricum intradermally at the base of tails to induce arthrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c91a219e00392f77a46dea66126a97b
https://pubmed.ncbi.nlm.nih.gov/10708568

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