Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Shigeharu Tanayama"'
Publikováno v:
Journal of Mass Spectrometry. 31:873-878
Combined liquid chromatography and electrospray mass spectrometry (LC/ESI-MS) and tandem mass spectrometry (MS/MS) were used for the characterization of the conjugated metabolites (glucuronides) of a new angiotensin II receptor antagonist, candesarta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f8cfd2dc8287d9c9e62b3eefb97d32
https://doi.org/10.1002/(sici)1096-9888(199608)31:8<873::aid-jms368>3.0.co
https://doi.org/10.1002/(sici)1096-9888(199608)31:8<873::aid-jms368>3.0.co
Autor:
Setsuo Harada, Yoshihiro Maeshiba, Nobuhiro Inatomi, Zen Itoh, Shigeharu Tanayama, Yasunori Funabashi, Satoshi Omura
Publikováno v:
The Journal of Antibiotics. 49:794-801
Two motilides, EM574 (N-demethyl-N-isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal) and EM523 (N-demethyl-N-ethyl-8,9-anhydroerythromycin A 6,9-hemiacetal) have strong gastrointestinal motor stimulating (GMS) activity. When administered orally to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b0e2c7d2e6dd519d77f7d5453065b4
https://doi.org/10.7164/antibiotics.49.794
https://doi.org/10.7164/antibiotics.49.794
Publikováno v:
Biopharmaceutics & Drug Disposition. 16:755-773
The enantioselective pharmacokinetics of a new anxiolytic, pazinaclone (DN-2327), and its active metabolite, M-II, were studied in animals. In rats and dogs given racemic pazinaclone intravenously, the total clearance and volume of distribution of (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5730d0deb1da7b4e7eb74585492b6778
https://doi.org/10.1002/bdd.2510160906
https://doi.org/10.1002/bdd.2510160906
Publikováno v:
Biological Mass Spectrometry. 23:323-329
Combined liquid chromatography/thermospray mass spectrometry (full scan) and its tandem mass spectrometry (precursor ion, product ion and neutral loss scan) were used to characterize rat and dog plasma metabolites of an anxiolytic candidate (DN-2327;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d973f98dd45b7a48b1d524b2658fd3
https://doi.org/10.1002/bms.1200230605
https://doi.org/10.1002/bms.1200230605
Autor:
Setsuo Harada, Zen Itoh, Nobuhiro Inatomi, Yoshihiro Maeshiba, Yasunori Funabashi, Satoshi Omura, Shigeharu Tanayama
Publikováno v:
ChemInform. 28
Two motilides, EM574 (N-demethyl-N-isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal) and EM523 (N-demethyl-N-ethyl-8,9-anhydroerythromycin A 6,9-hemiacetal) have strong gastrointestinal motor stimulating (GMS) activity. When administered orally to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c24c00becfb5218a939471e88667be1
https://doi.org/10.1002/chin.199706232
https://doi.org/10.1002/chin.199706232
Autor:
Yoshihiko Tagawa, Kiyoshi Miwa, Yusuke Tanigawara, Ryoichi Tsukuda, Shigeharu Tanayama, Yoshinobu Yoshimura, Kenji Yamashita
Publikováno v:
Biopharmaceuticsdrug disposition. 20(1)
A new antirheumatic, TAK-603, shows nonlinear pharmacokinetics in both animals and humans. To elucidate the mechanism of these nonlinear pharmacokinetics, in vivo and in vitro metabolism of 14 C-labeled TAK-603 ([ 14 C]TAK-603) was studied using rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be363f2672142422281eef93d84c4994
https://pubmed.ncbi.nlm.nih.gov/10086833
https://pubmed.ncbi.nlm.nih.gov/10086833
Autor:
Shigeharu Tanayama, Takahiro Kondo, Masashi Yamaguchi, Kiyoshi Yoshida, Kenji Hamasaki, Yoshinobu Yoshimura, Isamu Aoki
Publikováno v:
Journal of chromatography. B, Biomedical applications. 666(2)
A sensitive and specific high-performance liquid chromatographic method has been developed for the simultaneous determination of the enantiomers of pazinaclone (DN-2327), a new anxiolytic agent, and those of its active metabolite, M-II, in rat plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87030533aa62b6d80c0293c7cd555210
https://pubmed.ncbi.nlm.nih.gov/7633605
https://pubmed.ncbi.nlm.nih.gov/7633605
Autor:
Yoshikazu Oka, Kohei Nishikawa, Go Kito, Hiroshi Mayahara, Shigeharu Tanayama, Hiroshi Muto, Kentaro Hiraga
Publikováno v:
Cardiovascular Drug Reviews. 6:192-205
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::128bf6381b9ed2a51a07e46b9f194c8e
https://doi.org/10.1111/j.1527-3466.1988.tb00376.x
https://doi.org/10.1111/j.1527-3466.1988.tb00376.x
Autor:
Tohru Washino, Yoshio Esumi, Takuo Kobayashi, Toshiharu Ohtsuki, Shigeharu Tanayama, Hideaki Hohnoki
Publikováno v:
Xenobiotica. 18:49-59
1. Metabolites (RS)-4-[(3-hydroxy-2-methoxy)propoxycarbonylamino]butanoic acid (I) and (RS)-2-[(3-hydroxy-2-methoxy)propoxycarbonylamino]acetic acid(II) were isolated from urine after i.v. administration of (RS)-2-methoxy-3-(octadecyl-[14C]carbamoylo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3d733064200a2ed4d1c23f565b5a88
https://doi.org/10.3109/00498258809055136
https://doi.org/10.3109/00498258809055136
Publikováno v:
Folia Pharmacologica Japonica. 88:109-123
To investigate the possible action-sites of a cerebral metabolism activator, idebenone (CV-2619), its distribution in the brain and effect on local cerebral glucose utilization (LCGU) were studied both in normal rats (WKY) and in stroke-prone spontan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2787c5a28beb38ae113d1c8163e488c1
https://doi.org/10.1254/fpj.88.109
https://doi.org/10.1254/fpj.88.109