Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Shigeharu Nagasawa"'
Autor:
Masaki Hirashima, Yoshiro Saito, Kazuhiko Takahashi, Gen Takebe, Shigeharu Nagasawa, Noriko Sato
Publikováno v:
Biochemical Journal. 381:841-846
Human selenoprotein P (SeP), a selenium-rich plasma glycoprotein, is presumed to contain ten selenocysteine residues; one of which is located at the 40th residue in the N-terminal region and the remaining nine localized in the C-terminal third part.
Autor:
Kenji Funami, Teizo Fujita, Yusuke Murakami, Tadashi Matsuda, Tsukasa Seya, Natue Kishi, Aya Fukui, Shigeharu Nagasawa, Tomoko Yuasa-Nakagawa
Publikováno v:
Journal of Biochemistry. 132:719-728
Human C4b-binding protein (C4bp) facilitates the factor I-mediated proteolytic cleavage of the active forms of complement effectors C3b and C4b into their inactive forms. C4bp comprises a disulfide-linked heptamer of alpha-chains with complement (C)
Autor:
Yusuke Murakami, A Gogami, Y Miyagawa, Tadashi Baba, Asuka Nanbo, Hitoshi Nishimura, Shigeharu Nagasawa
Publikováno v:
Immunology. 103:519-525
The neutrophil bactericidal/permeability-increasing protein (BPI) has both bactericidal and lipopolysaccharide-neutralizing activities. The present study suggests that BPI also plays an important role in phagocytosis of Escherichia coli by neutrophil
Autor:
Tsukasa Seya, Michiyo Hatanaka, Yusuke Murakami, Misako Matsumoto, Shoki Mikata, Shigeharu Nagasawa, Taroh Kinoshita, N A Begum
Publikováno v:
Immunology. 100:131-139
In pig-to-human discordant xenotransplantation, human complement (C) is a major barrier to long survival of xenografts. The current idea on how to cope with this barrier is that human complement regulatory proteins are forcibly expressed on xenograft
Publikováno v:
International Immunology. 12:169-176
The transmembrane tyrosine phosphatase CD45 regulates the activity of src family protein tyrosine kinases (PTK) and thereby influences the signaling via such receptors as T and B cell antigen receptors associated with these PTK. However, its implicat
Autor:
Kaoru Hazeki, Osamu Hazeki, Tsuyoshi Matsuo, Tsukasa Seya, Toshiyuki Yamashita, Shigeharu Nagasawa, Hamid Band, Michio Ui
Publikováno v:
European Journal of Immunology. 29:3302-3312
Fcgamma receptors (FcgammaR) of guinea pig neutrophils were ligated and anti-Cbl immunoprecipitates prepared therefrom were assayed for the associated protein tyrosine kinase activity, which increased upon ligation of FcgammaR. The increases were ove
Autor:
Shuji Miyagawab, Shoki Mikata, Yusuke Murakami, Michiyo Hatanaka, Aya Fukui, Ryota Shirakura, Tsukasa Seya, Hikaru Matsuda, Koji Suzuki, Misako Matsumoto, Shigeharu Nagasawa
Publikováno v:
Molecular Immunology. 35:537-544
We designed a cDNA construct encoding an artificial membrane molecule consisting of all 8 short consensus repeats (SCRs) of human monomeric C4b-binding protein (C4bp) followed by DAF's GPI anchor, named mC4bp, and expressed the protein on swine endot
Autor:
Yasuhiko Suzuki, M Kitamura, T Hara, Tsukasa Seya, Hitoshi Nishimura, Shigeharu Nagasawa, T Nakazawa, M. Nishiguchi, Michiyo Hatanaka, Misako Matsumoto
Publikováno v:
Immunology. 93:546-555
We obtained a unique CD46 cDNA, STc/CY4, from the human testis, the predicted amino acid sequence of which suggested the presence of a novel isoform of CD46. This message was present predominantly in the testis, and the predicted isoform possessed a
Autor:
Tsukasa Seya, Shoki Mikata, Shigeharu Nagasawa, Ryota Shirakura, Michiyo Hatanaka, Wataru Kamiike, Kazunori Iwata, Shuji Miyagawa, Misako Matsumoto, Hikaru Matsuda
Publikováno v:
Transplantation. 65:363-368
Background. Human C4b-binding protein (C4bp) functions as a cofactor for factor I in the degradation of C4b and C3b and, in addition, accelerates the rate of decay of the C4b2a complex. Methods. In this study, we constructed a surface-bound form of h
Autor:
Shigeharu Nagasawa, Yusuke Murakami, Michiko Watanabe, Fumio Kobune, Hiroko Sakata, Misako Matsumoto, Mitsue Kurita, Shigeharu Ueda, Takesi Sato, Tsukasa Seya
Publikováno v:
Biological and Pharmaceutical Bulletin. 21:1121-1127
Down-regulation of CD46 secondary to stimulation with measles virus (MV) was investigated using CD46-positive cell lines and Japanese wild-type MV strains. The cells used were simian cell lines B95a and Vero in which MV strains have been adapted to b