Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Shigeharu Harada"'
Autor:
Dan Sato, Tomoo Shiba, Tsuyoshi Karaki, Wataru Yamagata, Tomoyoshi Nozaki, Takashi Nakazawa, Shigeharu Harada
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Pyridoxal 5′-phosphate (PLP)-enzymes are essentially involved in amino acid and amine metabolism of a wide variety of organisms. Despite their extensive biochemical studies, there are little evidence and structural data to comprehensively
Externí odkaz:
https://doaj.org/article/0aa82f516ed349f08d31dcde2ae3e576
Autor:
Dan Sato, Endah Dwi Hartuti, Daniel Ken Inaoka, Takaya Sakura, Eri Amalia, Madoka Nagahama, Yukina Yoshioka, Naotoshi Tsuji, Tomoyoshi Nozaki, Kiyoshi Kita, Shigeharu Harada, Makoto Matsubayashi, Tomoo Shiba
Publikováno v:
Genes, Vol 11, Iss 12, p 1468 (2020)
Dihydroorotate dehydrogenase (DHODH) is a mitochondrial monotopic membrane protein that plays an essential role in the pyrimidine de novo biosynthesis and electron transport chain pathways. In Eimeria tenella, an intracellular apicomplexan parasite t
Externí odkaz:
https://doaj.org/article/ea67b14e3920473784df5b84fd61f88f
Autor:
Yukiko Miyazaki, Daniel K. Inaoka, Tomoo Shiba, Hiroyuki Saimoto, Takaya Sakura, Eri Amalia, Yasutoshi Kido, Chika Sakai, Mari Nakamura, Anthony L. Moore, Shigeharu Harada, Kiyoshi Kita
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool. We have
Externí odkaz:
https://doaj.org/article/4343e700cc7f4f4caa097f95f6941062
Autor:
Daniel Ken Inaoka, Tomoo Shiba, Dan Sato, Emmanuel Oluwadare Balogun, Tsuyoshi Sasaki, Madoka Nagahama, Masatsugu Oda, Shigeru Matsuoka, Junko Ohmori, Teruki Honma, Masayuki Inoue, Kiyoshi Kita, Shigeharu Harada
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 7, Pp 15287-15308 (2015)
Recent studies on the respiratory chain of Ascaris suum showed that the mitochondrial NADH-fumarate reductase system composed of complex I, rhodoquinone and complex II plays an important role in the anaerobic energy metabolism of adult A. suum. The s
Externí odkaz:
https://doaj.org/article/b0fcf691f23a47cebda053894081c217
Autor:
Xinying Wang, Yukiko Miyazaki, Daniel Ken Inaoka, Endah Dwi Hartuti, Yoh-Ichi Watanabe, Tomoo Shiba, Shigeharu Harada, Hiroyuki Saimoto, Jeremy Nicholas Burrows, Francisco Javier Gamo Benito, Tomoyoshi Nozaki, Kiyoshi Kita
Publikováno v:
Genes, Vol 10, Iss 6, p 471 (2019)
Malaria is one of the three major global health threats. Drug development for malaria, especially for its most dangerous form caused by Plasmodium falciparum, remains an urgent task due to the emerging drug-resistant parasites. Exploration of novel a
Externí odkaz:
https://doaj.org/article/e7d29d3177fe45a1bff18eb7607d4371
Autor:
Makoto Matsubayashi, Daniel Ken Inaoka, Keisuke Komatsuya, Takeshi Hatta, Fumiya Kawahara, Kimitoshi Sakamoto, Kenji Hikosaka, Junya Yamagishi, Kazumi Sasai, Tomoo Shiba, Shigeharu Harada, Naotoshi Tsuji, Kiyoshi Kita
Publikováno v:
Genes, Vol 10, Iss 1, p 29 (2019)
Eimeria tenella is an intracellular apicomplexan parasite, which infects cecal epithelial cells from chickens and causes hemorrhagic diarrhea and eventual death. We have previously reported the comparative RNA sequence analysis of the E. tenella spor
Externí odkaz:
https://doaj.org/article/83626e8093c64e03bcb4ea4a42790f95
Autor:
Daniel Ken Inaoka, Maiko Iida, Toshiyuki Tabuchi, Teruki Honma, Nayoung Lee, Satoshi Hashimoto, Shigeru Matsuoka, Takefumi Kuranaga, Kazuhito Sato, Tomoo Shiba, Kimitoshi Sakamoto, Emmanuel Oluwadare Balogun, Shigeo Suzuki, Takeshi Nara, Josmar Rodrigues da Rocha, Carlos Alberto Montanari, Akiko Tanaka, Masayuki Inoue, Kiyoshi Kita, Shigeharu Harada
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167078 (2016)
Many open form (OF) structures of drug targets were obtained a posteriori by analysis of co-crystals with inhibitors. Therefore, obtaining the OF structure of a drug target a priori will accelerate development of potent inhibitors. In addition to its
Externí odkaz:
https://doaj.org/article/3a23ea416020435288da3735a0f01c84
Autor:
Ryunosuke Yoshino, Nobuaki Yasuo, Daniel Ken Inaoka, Yohsuke Hagiwara, Kazuki Ohno, Masaya Orita, Masayuki Inoue, Tomoo Shiba, Shigeharu Harada, Teruki Honma, Emmanuel Oluwadare Balogun, Josmar Rodrigues da Rocha, Carlos Alberto Montanari, Kiyoshi Kita, Masakazu Sekijima
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125829 (2015)
Chagas disease, caused by the parasite Trypanosoma cruzi, is a neglected tropical disease that causes severe human health problems. To develop a new chemotherapeutic agent for the treatment of Chagas disease, we predicted a pharmacophore model for T.
Externí odkaz:
https://doaj.org/article/4b0bac0f018a4bb7a714642595f2c480
Autor:
Masaki Murota, Kenji Inagaki, Shigeharu Harada, Yuki Onoue, Dan Sato, Tomoo Shiba, Atsushi Okawa, Masaya Hayashi, Junko Inagaki, Takashi Tamura
Publikováno v:
Protein Sci
l ‐Methionine decarboxylase (MetDC) from Streptomyces sp. 590 is a vitamin B(6)‐dependent enzyme and catalyzes the non‐oxidative decarboxylation of l ‐methionine to produce 3‐methylthiopropylamine and carbon dioxide. We present here the cry
Autor:
Daniel Ken Inaoka, Anthony L. Moore, Kiyoshi Kita, Takeshi Nara, Tomoo Shiba, Tomohiro Sato, Yoh-ichi Watanabe, Shigeharu Harada, Akiko Tanaka, Benjamin May, Paul A.M. Michels, Teruki Honma, Shigeru Matsuoka, Takashi Aoki, Chiaki Tsuge, Emmanuel Oluwadare Balogun, Yasutoshi Kido, Masayuki Inoue
Publikováno v:
The FASEB Journal. 33:13002-13013
African trypanosomiasis, sleeping sickness in humans or nagana in animals, is a potentially fatal neglected tropical disease and a threat to 65 million human lives and 100 million small and large l...