Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Shifa Jebari"'
Autor:
Asier Larrea‐Sebal, Iñaki Sasiain, Shifa Jebari‐Benslaiman, Unai Galicia‐Garcia, Kepa B. Uribe, Asier Benito‐Vicente, Irene Gracia‐Rubio, Harbil Bediaga‐Bañeres, Sonia Arrasate, Ana Cenarro, Fernando Civeira, Humberto González‐Díaz, Cesar Martín
Publikováno v:
Advanced Science, Vol 11, Iss 13, Pp n/a-n/a (2024)
Abstract Familial hypercholesterolemia (FH) is an inherited metabolic disease affecting cholesterol metabolism, with 90% of cases caused by mutations in the LDL receptor gene (LDLR), primarily missense mutations. This study aims to integrate six comm
Externí odkaz:
https://doaj.org/article/91edba494e384699a0634101a006d890
Autor:
Nicolás M. Suárez, Shifa Jebari-Benslaiman, Roberto Jiménez-Monzón, Asier Benito-Vicente, Yeray Brito-Casillas, Laida Garcés, Ana M. González-Lleo, Antonio Tugores, Mauro Boronat, César Martin, Ana M. Wägner, Rosa M. Sánchez-Hernández
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11319 (2023)
The p.(Tyr400_Phe402del) mutation in the LDL receptor (LDLR) gene is the most frequent cause of familial hypercholesterolaemia (FH) in Gran Canaria. The aim of this study was to determine the age and origin of this prevalent founder mutation and to e
Externí odkaz:
https://doaj.org/article/c1d7477560414ecb82a1f4bf2b208f71
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7659 (2023)
This Special Issue, “Cardiovascular Disease, Atherosclerosis and Familial Hypercholesterolemia: From Molecular Mechanisms Causing Pathogenicity to New Therapeutic Approaches”, contributes to advancing our knowledge of the molecular mechanisms tha
Externí odkaz:
https://doaj.org/article/28e3571fdcec466fbbef48d89b917eb3
Autor:
Asier Larrea-Sebal, Chiara Trenti, Shifa Jebari-Benslaiman, Stefano Bertolini, Sebastiano Calandra, Emanuele A. Negri, Efrem Bonelli, Asier Benito-Vicente, Leire Uraga-Gracianteparaluceta, César Martín, Tommaso Fasano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3330 (2023)
Familial hypercholesterolaemia (FH) is an autosomal dominant dyslipidaemia, characterised by elevated LDL cholesterol (LDL-C) levels in the blood. Three main genes are involved in FH diagnosis: LDL receptor (LDLr), Apolipoprotein B (APOB) and Protein
Externí odkaz:
https://doaj.org/article/83ca415e3111468c8d3293155e452740
Autor:
Thomas D. Madsen, Lasse H. Hansen, John Hintze, Zilu Ye, Shifa Jebari, Daniel B. Andersen, Hiren J. Joshi, Tongzhong Ju, Jens P. Goetze, Cesar Martin, Mette M. Rosenkilde, Jens J. Holst, Rune E. Kuhre, Christoffer K. Goth, Sergey Y. Vakhrushev, Katrine T. Schjoldager
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
O-glycosylation is an abundant post-translational modification but its relevance for bioactive peptides is unclear. Here, the authors detect O-glycans on almost one third of the classified peptide hormones and show that O-glycosylation can modulate p
Externí odkaz:
https://doaj.org/article/d81560792a8349198626ee05e6f9d81f
Autor:
Shifa Jebari-Benslaiman, Unai Galicia-García, Asier Larrea-Sebal, Javier Rekondo Olaetxea, Iraide Alloza, Koen Vandenbroeck, Asier Benito-Vicente, César Martín
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3346 (2022)
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous
Externí odkaz:
https://doaj.org/article/7424ef84092b42fdbdb074559b6c137c
Autor:
Yerai Vado, Gustavo Puras, Melania Rosique, Cesar Martin, Jose Luis Pedraz, Shifa Jebari-Benslaiman, Marian M. de Pancorbo, Jon Zarate, Guiomar Perez de Nanclares
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 696 (2021)
Background: Mesenchymal stem cells (MSCs) are stem cells present in adult tissues. They can be cultured, have great growth capacity, and can differentiate into several cell types. The isolation of urine-derived mesenchymal stem cells (hUSCs) was rece
Externí odkaz:
https://doaj.org/article/fbe828ec11ce44c782d4490a2e51c78d
Autor:
Asier Benito-Vicente, Kepa B. Uribe, Noemi Rotllan, Cristina M. Ramírez, Shifa Jebari-Benslaiman, Leigh Goedeke, Alberto Canfrán-Duque, Unai Galicia-García, Diego Saenz De Urturi, Patricia Aspichueta, Yajaira Suárez, Carlos Fernández-Hernando, Cesar Martín
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8675 (2020)
Insulin resistance (IR) is one of the key contributing factors in the development of type 2 diabetes mellitus (T2DM). However, the molecular mechanisms leading to IR are still unclear. The implication of microRNAs (miRNAs) in the pathophysiology of m
Externí odkaz:
https://doaj.org/article/0e48fd21c1a34a35bbca77b3cf0f1e9f
Autor:
Shifa Jebari-Benslaiman, Kepa B. Uribe, Asier Benito-Vicente, Unai Galicia-Garcia, Asier Larrea-Sebal, Iraide Alloza, Koen Vandenbroeck, Helena Ostolaza, César Martín
Publikováno v:
Biomedicines, Vol 8, Iss 10, p 373 (2020)
Cardiovascular disease (CVD), the leading cause of mortality worldwide is primarily caused by atherosclerosis, which is promoted by the accumulation of low-density lipoproteins into the intima of large arteries. Multiple nanoparticles mimicking natur
Externí odkaz:
https://doaj.org/article/60d02e3a7e134cf2af41145b49249735
Autor:
Unai Galicia-Garcia, Asier Benito-Vicente, Shifa Jebari, Asier Larrea-Sebal, Haziq Siddiqi, Kepa B. Uribe, Helena Ostolaza, César Martín
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6275 (2020)
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately
Externí odkaz:
https://doaj.org/article/4a8a429661a346cb9eb529281e3b984f