Výsledky vyhledávání - "Shie Feng-Shiun"

Akademický článek

TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5

Autor: Huang Fong-Lee, Yang Cheng-Ning, Shiao Young-Ji, Pan Chih-Ming, Shie Feng-Shiun, Yen Feng-Chang, Huang Wei-Chao, Sung Yen-Jen, Tsay Huey-Jen

Publikováno v: Journal of Neuroinflammation, Vol 7, Iss 1, p 28 (2010)

Abstract Background Overactivated microglia that cluster at neuritic plaques constantly release neurotoxins, which actively contribute to progressive neurodegeneration in Alzheimer's disease (AD). Therefore, attenuating microglial clustering can redu

Externí odkaz: https://doaj.org/article/276fc7632a4a469e9619f1fdf71b045f

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Akademický článek

Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein

Autor: Schantz Aimee M, Davis Jeanne, Wang Yan, Liu Jun, Shie Feng-Shiun, Jin Jinghua, Montine Kathleen S, Montine Thomas J, Zhang Jing

Publikováno v: Journal of Neuroinflammation, Vol 4, Iss 1, p 2 (2007)

Abstract Background The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of resident microglia in the brain may contribute significantly to neurode

Externí odkaz: https://doaj.org/article/ead1534d436947e49ac590dcfcc28980

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Akademický článek

Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo

Autor: Shie Feng-Shiun, Montine Kathleen S, Zaja-Milatovic Snjezana, Milatovic Dejan, Montine Thomas J

Publikováno v: Journal of Neuroinflammation, Vol 1, Iss 1, p 20 (2004)

Abstract The cause-and-effect relationship between innate immune activation and neurodegeneration has been difficult to prove in complex animal models and patients. Here we review findings from a model of direct innate immune activation via CD14 stim

Externí odkaz: https://doaj.org/article/d20469ac02a34737ac980575ad99ec16

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