Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Shie Chau Liu"'
Autor:
Lei Deng, Jason H. Stafford, Shie-Chau Liu, Sophia B. Chernikova, Milton Merchant, Lawrence Recht, J. Martin Brown
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 1, Pp 1-7 (2017)
Despite the approval of antiangiogenic therapy for glioblastoma multiforme (GBM) patients, survival benefits are still limited. One of the resistance mechanisms for antiangiogenic therapy is the induction of hypoxia and subsequent recruitment of macr
Externí odkaz:
https://doaj.org/article/9a063b90518c43ef8b06f0db5778ff48
Autor:
Keshav Datta, Mette H Lauritzen, Milton Merchant, Taichang Jang, Shie-Chau Liu, Ralph Hurd, Lawrence Recht, Daniel M Spielman
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225313 (2019)
BackgroundMetabolism in tumor shifts from oxidative phosphorylation to inefficient glycolysis resulting in overproduction of lactate (Warburg effect), and cancers may be effectively treated if this imbalance were corrected. The aim of this longitudin
Externí odkaz:
https://doaj.org/article/136966632a074d21ad12676d4c066038
Supplementary Table 1 from Optimized Clostridium-Directed Enzyme Prodrug Therapy Improves the Antitumor Activity of the Novel DNA Cross-Linking Agent PR-104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad21e7799cc42c0d035bf8ab0a961a0c
https://doi.org/10.1158/0008-5472.22375538
https://doi.org/10.1158/0008-5472.22375538
We have previously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered to express the E. coli–derived cytosine deaminase gene are effective in converting systemically injected nontoxic 5-fluorocytosine int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf1163fd73172d9605cd124ac77a1cd
https://doi.org/10.1158/0008-5472.c.6497861
https://doi.org/10.1158/0008-5472.c.6497861
Publikováno v:
ACS Chemical Biology. 12:1737-1742
Reactive oxygen species (ROS) are essential cellular metabolites widely implicated in many diseases including cancer, inflammation, and cardiovascular and neurodegenerative disorders. Yet, ROS signaling remains poorly understood, and their measuremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7840ecb28b9382ce72a084a64f040dc
https://doi.org/10.1021/acschembio.7b00130
https://doi.org/10.1021/acschembio.7b00130
Autor:
Daniel M. Spielman, Keshav Datta, Jae Mo Park, Shie Chau Liu, Andrew Castillo, Kelvin L. Billingsley, Marvin Wu, Heather Lough
Publikováno v:
Journal of the American Chemical Society. 139:6629-6634
Hyperpolarized 13C magnetic resonance spectroscopy (MRS) provides unprecedented opportunities to obtain clinical diagnostic information through in vivo monitoring of metabolic pathways. The continuing advancement of this field relies on the identific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ad86f3dd38388ba0624d84fac6ebca
https://doi.org/10.1021/jacs.7b00708
https://doi.org/10.1021/jacs.7b00708
Publikováno v:
Magnetic Resonance in Medicine. 77:1741-1748
PURPOSE The intracellular lactate to pyruvate concentration ratio is a commonly used tissue assay biomarker of redox, being proportional to free cytosolic [NADH]/[NAD+ ]. In this study, we assessed the use of hyperpolarized [1-13 C]alanine and the su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2db4991d9c3c81d8f8764ccb06574af
https://doi.org/10.1002/mrm.26662
https://doi.org/10.1002/mrm.26662
Autor:
J. Martin Brown, Milton Merchant, Lawrence Recht, Lei Deng, Sophia B. Chernikova, Shie-Chau Liu, Jason Stafford
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 1, Pp 1-7 (2017)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Despite the approval of antiangiogenic therapy for glioblastoma multiforme (GBM) patients, survival benefits are still limited. One of the resistance mechanisms for antiangiogenic therapy is the induction of hypoxia and subsequent recruitment of macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4909417657a0be0efd8657646746ee69
http://www.sciencedirect.com/science/article/pii/S1476558616302950
http://www.sciencedirect.com/science/article/pii/S1476558616302950
Autor:
Daniel M. Spielman, Keshav Datta, Lawrence Recht, Taichang Jang, Shie-Chau Liu, Milton Merchant, Ralph E. Hurd, Mette H. Lauritzen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0225313 (2019)
PLoS ONE, Vol 14, Iss 12, p e0225313 (2019)
BackgroundMetabolism in tumor shifts from oxidative phosphorylation to inefficient glycolysis resulting in overproduction of lactate (Warburg effect), and cancers may be effectively treated if this imbalance were corrected. The aim of this longitudin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c1a4aa6107ed81af5d91c82b8562fa
https://pubmed.ncbi.nlm.nih.gov/31830049
https://pubmed.ncbi.nlm.nih.gov/31830049
Autor:
Laurence Recht, Maksim Sinyuk, Justin D. Lathia, Jason Karamchandani, T. J. Schall, Robert D. Berahovich, J. C. Jaen, R. Al Omran, Richard M. Ransohoff, M. E T Penfold, Shie-Chau Liu, P. Zhang, J. P. Powers, Diane Tseng, Karen Ebsworth, Holbrook E Kohrt, M. J. Walters, Sophia B. Chernikova, J M Brown, Erin E. Mulkearns-Hubert, Milton Merchant, M. Kioi
Publikováno v:
British Journal of Cancer
Background: In experimental models of glioblastoma multiforme (GBM), irradiation (IR) induces local expression of the chemokine CXCL12/SDF-1, which promotes tumour recurrence. The role of CXCR7, the high-affinity receptor for CXCL12, in the tumour's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55d3e5413c5f4fb6c133c22316ec431
https://doi.org/10.1038/bjc.2013.830
https://doi.org/10.1038/bjc.2013.830