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Autor:
Schenck, Ryan O., Kim, Eunjung, Bravo, Rafael R., West, Jeffrey, Leedham, Simon, Shibata, Darryl, Anderson, Alexander R. A.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2022 Aug . 119(35), 1-8.
Externí odkaz:
https://www.jstor.org/stable/27171626
Autor:
Shibata Darryl, Calabrese Peter
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 3 (2010)
Abstract Background The purpose of this article is to present a relatively easy to understand cancer model where transformation occurs when the first cell, among many at risk within a colon, accumulates a set of driver mutations. The analysis of this
Externí odkaz:
https://doaj.org/article/073f63101d29409cbe5452729d95a44c
Publikováno v:
Journal of Translational Medicine, Vol 6, Iss 1, p 26 (2008)
Abstract Background Interleukin-12 (IL-12) is a cytokine well known for its role in immunity. A lesser known function of IL-12 is its role in hematopoiesis. The promising data obtained in the preclinical models of antitumor immunotherapy raised hope
Externí odkaz:
https://doaj.org/article/16ca5f71f0de49da85e863ffb967e2e7
Autor:
Kanel Gary C, Yang Allen S, Kim Jung, Eckstam Carrie L, Siegmund Kimberly D, Chu Michelle W, Tavaré Simon, Shibata Darryl
Publikováno v:
BMC Medical Genetics, Vol 8, Iss 1, p 50 (2007)
Abstract Background Cell division occurs during normal human development and aging. Despite the likely importance of cell division to human pathology, it has been difficult to infer somatic cell mitotic ages (total numbers of divisions since the zygo
Externí odkaz:
https://doaj.org/article/e740e11f77db4d12baa9232777a20d56
Publikováno v:
BMC Biology, Vol 4, Iss 1, p 2 (2006)
Abstract Background Stem cells divide to reproduce themselves and produce differentiated progeny. A fundamental problem in human biology has been the inability to measure how often stem cells divide. Although it is impossible to observe every divisio
Externí odkaz:
https://doaj.org/article/125c37498eef4b6f82e5b8b05ae302c1
Autor:
Tavaré Simon, Aaltonen Lauri A, Järvinen Heikki J, Mecklin Jukka-Pekka, Calabrese Peter, Shibata Darryl
Publikováno v:
BMC Cancer, Vol 5, Iss 1, p 126 (2005)
Abstract Background The numbers of oncogenic mutations required for transformation are uncertain but may be inferred from how cancer frequencies increase with aging. Cancers requiring more mutations will tend to appear later in life. This type of app
Externí odkaz:
https://doaj.org/article/e3d2b37cbde645939a69c60ceb9ef6f5
Publikováno v:
BMC Gastroenterology, Vol 5, Iss 1, p 19 (2005)
Abstract Background Methylation at certain human CpG rich sequences increases with age. The mechanisms underlying such age-related changes are unclear, but methylation may accumulate slowly in a clock-like manner from birth and record lifetime number
Externí odkaz:
https://doaj.org/article/568bde034628402cb48ae9cdae3bdc01
Publikováno v:
BMC Medicine, Vol 3, Iss 1, p 10 (2005)
Abstract Background The small intestine is constructed of many crypts and villi, and mouse studies suggest that each crypt contains multiple stem cells. Very little is known about human small intestines because mouse fate mapping strategies are impra
Externí odkaz:
https://doaj.org/article/e197e0f795dc49f4af380944fe692863
Autor:
Shibata Darryl, Kim Kyoung-Mee
Publikováno v:
BMC Gastroenterology, Vol 4, Iss 1, p 8 (2004)
Abstract Background The ability to discern ancestral relationships between individual human colon crypts is limited. Widely separated crypts likely trace their common ancestors to a time around birth, but closely spaced adult crypts may share more re
Externí odkaz:
https://doaj.org/article/6a67af812e414fe19ab528f01a4001da