Endothelial Heterogeneity in the Response to Autophagy Drives Small Vessel Muscularization in Pulmonary Hypertension.

Autor: Qi Zhang, Yaoita, Nobuhiro, Tabuchi, Arata, Shaofei Liu, Shiau-Haln Chen, Qiuhua Li, Hegemann, Niklas, Caihong Li, Rodor, Julie, Timm, Sara, Laban, Hebatullah, Finkel, Toren, Stevens, Troy, Alvarez, Diego F., Erfinanda, Lasti, de Perrot, Marc, Kucherenko, Mariya M., Knosalla, Christoph, Ochs, Matthias, Dimmeler, Stefanie

Publikováno v: Circulation; 8/6/2024, Vol. 150 Issue 6, p466-487, 22p

DECIPHERING ENDOTHELIAL HETEROGENEITY IN HEALTH AND DISEASE AT SINGLE CELL RESOLUTION: PROGRESS AND PERSPECTIVES

Autor: Lisa M Becker, Shiau-Haln Chen, Julie Rodor, Laura P M H de Rooij, Andrew H Baker, Peter Carmeliet

Publikováno v: Becker, L M, Chen, S-H, Rodor, J, de Rooij, L P M H, Baker, A H & Carmeliet, P 2022, ' Deciphering endothelial heterogeneity in health and disease at single cell resolution: progress and perspectives ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvac018
Becker, L M, Chen, S H, Rodor, J, de Rooij, L P M H, Baker, A H & Carmeliet, P 2023, ' Deciphering endothelial heterogeneity in health and disease at single-cell resolution : progress and perspectives ', Cardiovascular Research, vol. 119, no. 1, pp. 6-27 . https://doi.org/10.1093/cvr/cvac018
CARDIOVASCULAR RESEARCH

Endothelial cells (ECs) constitute the inner lining of vascular beds in mammals and are crucial for homeostatic regulation of blood vessel physiology, but also play a key role in pathogenesis of many diseases, thereby representing realistic therapeut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d520683b861c549b627332bacd7568d2
https://pubmed.ncbi.nlm.nih.gov/35179567

Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension

Autor: Peter Carmeliet, Robert Lafyatis, Mark Southwood, João P Monteiro, Katherine M Ross Stewart, Andrew H. Baker, Ana-Mishel Spiroski, Mairi Brittan, Jessica P. Scanlon, Neil C. Henderson, Paul D. Upton, Kevin Stewart, Shiau Haln Chen, Patrick W. F. Hadoke, Sweta Sweta, Ziwen Li, Alena Shmakova, Adam Handen, Stephen D Moore, Julie Rodor, Stephen Y. Chan, Axelle Caudrillier, Ross Dobie, Laura P.M.H. de Rooij, Beth Ep Henderson, Nicholas W. Morrell

Publikováno v: Rodor, J, Chen, S H, Scanlon, J P, Monteiro, J P, Caudrillier, A, Sweta, S, Ross Stewart, K, Shmakova, A, Dobie, R, Henderson, B EP, Stewart, K, Hadoke, P W F, Southwood, M, Moore, S D, Upton, P D, Morrell, N W, Li, Z, Chan, S Y, Handen, A, Lafyatis, R, de Rooij, L P M H, Henderson, N C, Carmeliet, P, Spiroski, A-M, Brittan, M & Baker, A H 2021, ' Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvab296

AimsEndothelial cell (EC) dysfunction drives the initiation and pathogenesis of pulmonary arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell resolution.Methods and resultsWe carried out single-cell RNA sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891a9d5ea79aa7f348c696c61724c06b
https://www.pure.ed.ac.uk/ws/files/227519929/cvab296.pdf

The British Microcirculation & Vascular Biology Society (Formerly the British Microcirculation Society): Abstracts of the 71^st annual meeting (Virtual), hosted by University of Leeds, UK Editor: Doctor Andrea Murray Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, UK

Publikováno v: Microcirculation. Jan2022, Vol. 29 Issue 1, p1-35. 35p.

Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension.

Autor: Rodor, Julie, Chen, Shiau Haln, Scanlon, Jessica P, Monteiro, João P, Caudrillier, Axelle, Sweta, Sweta, Stewart, Katherine Ross, Shmakova, Alena, Dobie, Ross, Henderson, Beth E P, Stewart, Kevin, Hadoke, Patrick W F, Southwood, Mark, Moore, Stephen D, Upton, Paul D, Morrell, Nick W, Li, Ziwen, Chan, Stephen Y, Handen, Adam, Lafyatis, Robert

Publikováno v: Cardiovascular Research; Jul2022, Vol. 118 Issue 11, p2519-2534, 16p