Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Shiau-Choot Tang"'
Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
Autor:
Kerry L. Hilligan, Shiau-Choot Tang, Evelyn J. Hyde, Elsa Roussel, Johannes U. Mayer, Jianping Yang, Kirsty A. Wakelin, Alfonso J. Schmidt, Lisa M. Connor, Alan Sher, Andrew S. MacDonald, Franca Ronchese
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Antigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and mon
Externí odkaz:
https://doaj.org/article/d65f3d80f398424cae180d6d1bb01a61
Autor:
Christophe Pellefigues, Shiau-Choot Tang, Alfonso Schmidt, Ruby F. White, Olivier Lamiable, Lisa M. Connor, Christiane Ruedl, Jurek Dobrucki, Graham Le Gros, Franca Ronchese
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The induction of Th2 responses is thought to be multifactorial, and emerge from specific pathways distinct from those associated with antagonistic antibacterial or antiviral Th1 responses. Here, we show that the recognition of non-viable Nippostrongy
Externí odkaz:
https://doaj.org/article/99474805f78f46a9abf15daf4e5aa868
Autor:
Kirsty A. Wakelin, Greta R Webb, Frank Brombacher, Lisa M Connor, Alan Sher, Sventja von Daake, David Gallego-Ortega, Luis Munoz-Erazo, Jianping Yang, Franca Ronchese, Sally Chappell, Charles R. Mackay, Johannes U Mayer, Dragana Jankovic, Matthew R. Hepworth, Graham Le Gros, David Eccles, Shiau-Choot Tang, Jodie Chandler, Olivier Lamiable, Kerry L Hilligan, Samuel I Old, Evelyn J Hyde, Rita G. Domingues, Roxane Tussiwand
Publikováno v:
Nature Immunology. 22:1538-1550
The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11blo migratory DC2s-a DC2 population unique to the dermis-required IL-13 signaling depe
Autor:
Johannes U. Mayer, Kerry L. Hilligan, Jodie S. Chandler, David A. Eccles, Samuel I. Old, Rita G. Domingues, Jianping Yang, Greta R. Webb, Luis Munoz-Erazo, Evelyn J. Hyde, Kirsty A. Wakelin, Shiau-Choot Tang, Sally C. Chappell, Sventja von Daake, Frank Brombacher, Charles R. Mackay, Alan Sher, Roxane Tussiwand, Lisa M. Connor, David Gallego-Ortega, Dragana Jankovic, Graham Le Gros, Matthew R. Hepworth, Olivier Lamiable, Franca Ronchese
In the version of this article initially published, there were labeling errors in Fig. 8. In Fig. 8a, the top row, now reading “GSE43184:CD1c+ lung versus blood,” originally appeared as “GSE35457….” The bottom row, now reading “GSE35457:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff24999b9482f93856ec7fdd01b8fcba
https://hdl.handle.net/10453/167364
https://hdl.handle.net/10453/167364
Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
Autor:
Lisa M Connor, Kirsty A. Wakelin, Alfonso J Schmidt, Alan Sher, Kerry L. Hilligan, Andrew S. MacDonald, Johannes U Mayer, Shiau-Choot Tang, Jianping Yang, Elsa Roussel, Evelyn J Hyde, Franca Ronchese
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Hilligan, K L, Tang, S-C, Hyde, E J, Roussel, E, Mayer, J U, Yang, J, Wakelin, K A, Schmidt, A J, Connor, L M, Sher, A, MacDonald, A S & Ronchese, F 2020, ' Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles ', Nature Communications, vol. 11, no. 1, pp. 5637 . https://doi.org/10.1038/s41467-020-19463-9
Nature Communications
Hilligan, K L, Tang, S-C, Hyde, E J, Roussel, E, Mayer, J U, Yang, J, Wakelin, K A, Schmidt, A J, Connor, L M, Sher, A, MacDonald, A S & Ronchese, F 2020, ' Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles ', Nature Communications, vol. 11, no. 1, pp. 5637 . https://doi.org/10.1038/s41467-020-19463-9
Nature Communications
Antigen (Ag)-presenting cells (APC) instruct CD4+ helper T (Th) cell responses, but it is unclear whether different APC subsets contribute uniquely in determining Th differentiation in pathogen-specific settings. Here, we use skin-relevant, fluoresce
Autor:
Johannes U, Mayer, Kerry L, Hilligan, Jodie S, Chandler, David A, Eccles, Samuel I, Old, Rita G, Domingues, Jianping, Yang, Greta R, Webb, Luis, Munoz-Erazo, Evelyn J, Hyde, Kirsty A, Wakelin, Shiau-Choot, Tang, Sally C, Chappell, Sventja, von Daake, Frank, Brombacher, Charles R, Mackay, Alan, Sher, Roxane, Tussiwand, Lisa M, Connor, David, Gallego-Ortega, Dragana, Jankovic, Graham, Le Gros, Matthew R, Hepworth, Olivier, Lamiable, Franca, Ronchese
Publikováno v:
Nature immunology. 22(12)
The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11b
The skin environment controls local dendritic cell differentiation and function through innate IL-13
Autor:
Kerry L Hilligan, Luis Munoz-Erazo, Lisa M Connor, Sally Chappell, Alan Sher, Franca Ronchese, Charles R. Mackay, Olivier Lamiable, Graham Le Gros, Jianping Yang, Dragana Jankovic, Kirsty A. Wakelin, Matthew R. Hepworth, David Eccles, Greta R Webb, Frank Brombacher, Evelyn J Hyde, Jodie Chandler, Samuel I Old, Roxane Tussiwand, Rita G. Domingues, Johannes U Mayer, Shiau-Choot Tang
The signals driving the adaptation of type-2 dendritic cells (DC2s) to diverse peripheral environments are not well understood. We show that the development of CD11blow migratory DC2s, a DC2 population unique to the dermis, requires STAT6- and KLF4-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a3c3ad77cbcaf7b0a32bb495053eddc
https://doi.org/10.1101/2021.01.05.425466
https://doi.org/10.1101/2021.01.05.425466
Autor:
Martin Guilliams, Sofie De Prijck, David L. Williams, Cedric Bosteels, Franca Ronchese, Katrijn Neyt, Bart N. Lambrecht, Yvan Saeys, Charlotte L. Scott, Manon Lesage, Hamida Hammad, Niels Vandamme, Liesbet Martens, Manon Vanheerswynghels, Mary J. van Helden, Victor Bosteels, Dorine Sichien, Els Louagie, Johannes U Mayer, Shiau-Choot Tang, Nincy Debeuf
Publikováno v:
Immunity
Immunity, 52(6), 1039-1056. Cell Press
Cell Mol Immunol
Immunity, 52(6), 1039-1056. Cell Press
Cell Mol Immunol
Summary The phenotypic and functional dichotomy between IRF8+ type 1 and IRF4+ type 2 conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it is unknown how robust this dichotomy is under inflammatory conditions, when additi
Autor:
Jurek Dobrucki, Shiau-Choot Tang, Alfonso J Schmidt, Franca Ronchese, Olivier Lamiable, Graham Le Gros, Ruby F. White, Christophe Pellefigues, Christiane Ruedl, Lisa M. Connor
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The induction of Th2 responses is thought to be multifactorial, and emerge from specific pathways distinct from those associated with antagonistic antibacterial or antiviral Th1 responses. Here, we show that the recognition of non-viable Nippostrongy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45797b6245dfe961381b03c7e4626904
https://hdl.handle.net/10356/87377
https://hdl.handle.net/10356/87377
Publikováno v:
The Journal of Immunology. 193:2709-2717
Dendritic cells (DC) are critical for the initiation of immune responses; however, their role in priming IL-4–producing Th2 cells in vivo is not fully understood. We used a model of intradermal injection with fluorescent-labeled, nonviable larvae f