Structure of LRRK2 in Parkinson's disease and model for microtubule interaction

Autor: Deniston, CK, Salogiannis, J, Mathea, S, Snead, DM, Lahiri, I, Matyszewski, M, Donosa, O, Watanabe, R, Böhning, J, Shiau, AK, Knapp, S, Villa, E, Reck-Peterson, SL, Leschziner, AE

Publikováno v: Nature, vol 588, iss 7837

Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial Parkinson's disease1 and is also linked to its idiopathic form2. LRRK2 has been proposed to function in membrane trafficking3 and colocalizes with microtubules4. Despi

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https://escholarship.org/uc/item/47b0z2th

The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly.

Autor: de Groot C; Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093.; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA 92093., Houston J; Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093., Davis B; Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093.; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA 92093.; Department of Biology and Chemistry, Embry-Riddle Aeronautical University, Prescott, AZ 86301., Gerson-Gurwitz A; Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093.; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA 92093., Monen J; Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093.; School of Theoretical & Applied Science, Ramapo College of New Jersey, Mahwah, NJ 07430., Lara-Gonzalez P; Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093., Oegema K; Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093.; Section of Cell & Developmental Biology, Division of Biological Sciences and.; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA 92093., Shiau AK; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA 92093.; Section of Cell & Developmental Biology, Division of Biological Sciences and., Desai A; Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093.; Section of Cell & Developmental Biology, Division of Biological Sciences and.; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA 92093.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2021 Jun 01; Vol. 32 (12), pp. 1193-1201. Date of Electronic Publication: 2021 Apr 14.

Exploring compound suitability and employing DFT calculations, molecular docking, and dynamics simulation to investigate potent compounds from podophyllum medicinal plants for breast cancer therapy.

Autor: Mande, Srinivasarao¹ (AUTHOR), Repudi, Lalitha¹ (AUTHOR), Goswami, Sanchari¹ (AUTHOR), Nallasivan, P. Kumar² (AUTHOR), Gandla, Kumaraswamy¹ (AUTHOR) drkumaraswamygandla@gmail.com

Publikováno v: Bulletin of the National Research Centre. 10/14/2024, Vol. 48 Issue 1, p1-11. 11p.

Comprehensive analysis of single cell ATAC-seq data with SnapATAC.

Autor: Fang R; Ludwig Institute for Cancer Research, La Jolla, CA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Preissl S; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Li Y; Ludwig Institute for Cancer Research, La Jolla, CA, USA., Hou X; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Lucero J; The Salk Institute for Biological Studies, La Jolla, CA, USA., Wang X; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Motamedi A; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA, USA., Shiau AK; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA, USA., Zhou X; Biomedical Science Graduate Program, University of California San Diego, La Jolla, CA, USA., Xie F; Department of Physics, University of California, San Diego, La Jolla, CA, USA., Mukamel EA; Department of Physics, University of California, San Diego, La Jolla, CA, USA., Zhang K; Ludwig Institute for Cancer Research, La Jolla, CA, USA., Zhang Y; Ludwig Institute for Cancer Research, La Jolla, CA, USA., Behrens MM; The Salk Institute for Biological Studies, La Jolla, CA, USA., Ecker JR; The Salk Institute for Biological Studies, La Jolla, CA, USA.; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA, USA., Ren B; Ludwig Institute for Cancer Research, La Jolla, CA, USA. biren@ucsd.edu.; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA. biren@ucsd.edu.; Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, UCSD Moores Cancer Center, La Jolla, CA, USA. biren@ucsd.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Feb 26; Vol. 12 (1), pp. 1337. Date of Electronic Publication: 2021 Feb 26.

Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.

Autor: Deniston CK; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Genomics Institute of the Novartis Research Foundation, La Jolla, CA, USA., Salogiannis J; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Mathea S; Institute of Pharmaceutical Chemistry, Goethe-Universität, Frankfurt, Germany., Snead DM; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Lahiri I; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Mohali, India., Matyszewski M; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Donosa O; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Watanabe R; Division of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA, USA.; La Jolla Institute for Immunology, La Jolla, CA, USA., Böhning J; Division of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA, USA.; Sir William Dunn School of Pathology, Oxford University, Oxford, UK., Shiau AK; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA, USA.; Division of Biological Sciences, Cell and Developmental Biology Section, University of California San Diego, La Jolla, CA, USA., Knapp S; Institute of Pharmaceutical Chemistry, Goethe-Universität, Frankfurt, Germany., Villa E; Division of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA, USA., Reck-Peterson SL; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. sreckpeterson@ucsd.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. sreckpeterson@ucsd.edu.; Division of Biological Sciences, Cell and Developmental Biology Section, University of California San Diego, La Jolla, CA, USA. sreckpeterson@ucsd.edu., Leschziner AE; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. aleschziner@ucsd.edu.; Division of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA, USA. aleschziner@ucsd.edu.

Publikováno v: Nature [Nature] 2020 Dec; Vol. 588 (7837), pp. 344-349. Date of Electronic Publication: 2020 Aug 19.