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Autor:
Choy J; Cardio-Metabolic Diseases, Merck & Co., Inc., South San Francisco, CA, USA.; Maze Therapeutics, South San Francisco, CA, USA., Kan Y; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Cifelli S; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Johnson J; Cardio-Metabolic Diseases, Merck & Co., Inc., South San Francisco, CA, USA., Chen M; Cardio-Metabolic Diseases, Merck & Co., Inc., South San Francisco, CA, USA., Shiao LL; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Zhou H; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Previs S; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Lei Y; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Johnstone R; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Liaw A; Biometrics Research, Merck & Co., Inc., Rahway, NJ, USA., Saigal A; Cardio-Metabolic Diseases, Merck & Co., Inc., South San Francisco, CA, USA., Hu L; Cardio-Metabolic Diseases, Merck & Co., Inc., South San Francisco, CA, USA., Ramos R; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Visconti R; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA.; Bristol Myers Squibb, New York, NY, USA., McElroy WT; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA.; Constellation Pharmaceuticals, Cambridge, MA, USA., Kreamer A; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Wildey MJ; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Peier A; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Shin MK; Genetics and Pharmacogenomics, Merck & Co., Inc., Kenilworth, NJ, USA., Imbriglio J; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Ren Z; Cardio-Metabolic Diseases, Merck & Co., Inc., South San Francisco, CA, USA., Hoek M; Cardio-Metabolic Diseases, Merck & Co., Inc., South San Francisco, CA, USA.; Maze Therapeutics, South San Francisco, CA, USA., Weinglass A; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA., Ai X; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ, USA.
Publikováno v:
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Oct; Vol. 26 (9), pp. 1225-1237. Date of Electronic Publication: 2021 Jul 03.
Autor:
Chobanian HR; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Guo Y; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Liu P; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Chioda MD; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Fung S; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Lanza TJ; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Chang L; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Bakshi RK; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Dellureficio JP; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Hong Q; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., McLaughlin M; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Belyk KM; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Krska SW; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Makarewicz AK; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Martel EJ; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Leone JF; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Frey L; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Karanam B; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Madeira M; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Alvaro R; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Shuman J; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Salituro G; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Terebetski JL; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Jochnowitz N; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Mistry S; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., McGowan E; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Hajdu R; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Rosenbach M; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Abbadie C; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Alexander JP; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Shiao LL; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Sullivan KM; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Nargund RP; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Wyvratt MJ; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., Lin LS; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States., DeVita RJ; Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Immunology, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2014 Apr 10; Vol. 5 (6), pp. 717-21. Date of Electronic Publication: 2014 Apr 10 (Print Publication: 2014).