Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Shiang Y. Lim"'
Autor:
Jarmon G. Lees, David W. Greening, David A. Rudd, Jonathon Cross, Ayeshah A. Rosdah, Xiangfeng Lai, Tsung Wu Lin, Ren Jie Phang, Anne M. Kong, Yali Deng, Simon Crawford, Jessica K. Holien, Derek J. Hausenloy, Hsin-Hui Shen, Shiang Y. Lim
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 9, Iss , Pp 100085- (2024)
Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein and a viable target for cardioprotection against myocardial ischaemia-reperfusion injury. Here, we reported a novel Drp1 inhibitor (DRP1i1), delivered using a cardiac-targeted nanopa
Externí odkaz:
https://doaj.org/article/c5ae7e34af804835a24c75f371f23c34
NOS3 regulates angiogenic potential of human induced pluripotent stem cell-derived endothelial cells
Autor:
Anne M. Kong, Zulhusni A. Idris, Daniel Urrutia-Cabrera, Jarmon G. Lees, Ren Jie Phang, Geraldine M. Mitchell, Raymond C.B. Wong, Shiang Y. Lim
Publikováno v:
Biochemistry and Biophysics Reports, Vol 40, Iss , Pp 101876- (2024)
Incorporation of blood capillaries in engineered tissues and their functional connection to host blood vessels is essential for success in engineering vascularized tissues, a process which involves spatial patterning of endothelial cells (ECs) to for
Externí odkaz:
https://doaj.org/article/3bda5a01d9c2428a96a8000999628684
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 12, Pp n/a-n/a (2023)
Abstract Pathological reprogramming of cardiomyocyte and fibroblast proteome landscapes drive the initiation and progression of cardiac fibrosis. Although the secretome of dysfunctional cardiomyocytes is emerging as an important driver of pathologica
Externí odkaz:
https://doaj.org/article/be664b2f7a84403da7b8c1d3b4b8d54d
Autor:
Ayeshah A. Rosdah, Belinda M. Abbott, Christopher G. Langendorf, Yali Deng, Jia Q. Truong, Helen M. M. Waddell, Naomi X. Y. Ling, William J. Smiles, Lea M. D. Delbridge, Guei-Sheung Liu, Jonathan S. Oakhill, Shiang Y. Lim, Jessica K. Holien
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous pathophysiological processes. Despite being the most widely used Drp1 inhibitor, the spec
Externí odkaz:
https://doaj.org/article/81d43f7ed5984ba3b02b0644c4d9b73f
Autor:
Quanxia Lyu, Shu Gong, Jarmon G. Lees, Jialiang Yin, Lim Wei Yap, Anne M. Kong, Qianqian Shi, Runfang Fu, Qiang Zhu, Ash Dyer, Jennifer M. Dyson, Shiang Y. Lim, Wenlong Cheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
It is challenging to directly characterize mechanical properties of soft 3D cardiac organoids with current sensors. Here the authors report an electronic skin-based all-soft organoid-sensing system which can wirelessly monitor minute force profiles o
Externí odkaz:
https://doaj.org/article/afa1825aa9394eed867874bf4d43c70c
Autor:
Serena Viventi, Stefano Frausin, Sara E. Howden, Shiang Y. Lim, Rocio K. Finol‐Urdaneta, Jeffrey R. McArthur, Kwaku Dad Abu‐Bonsrah, Wayne Ng, Jason Ivanusic, Lachlan Thompson, Mirella Dottori
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 8, Pp 1157-1169 (2021)
Abstract Friedreich ataxia (FRDA) is an autosomal recessive disease characterized by degeneration of dorsal root ganglia (DRG) sensory neurons, which is due to low levels of the mitochondrial protein Frataxin. To explore cell replacement therapies as
Externí odkaz:
https://doaj.org/article/2403739491274763baadfc37b82dc9ee
Autor:
Maciej Daniszewski, Anne Senabouth, Helena H. Liang, Xikun Han, Grace E. Lidgerwood, Damián Hernández, Priyadharshini Sivakumaran, Jordan E. Clarke, Shiang Y. Lim, Jarmon G. Lees, Louise Rooney, Lerna Gulluyan, Emmanuelle Souzeau, Stuart L. Graham, Chia-Ling Chan, Uyen Nguyen, Nona Farbehi, Vikkitharan Gnanasambandapillai, Rachael A. McCloy, Linda Clarke, Lisa S. Kearns, David A. Mackey, Jamie E. Craig, Stuart MacGregor, Joseph E. Powell, Alice Pébay, Alex W. Hewitt
Publikováno v:
Cell Genomics, Vol 2, Iss 6, Pp 100142- (2022)
Summary: To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retin
Externí odkaz:
https://doaj.org/article/bda5107c7c8a45e0aa69bcd697f93428
Autor:
Omar Lozano, Christian Silva-Platas, Héctor Chapoy-Villanueva, Baruc E. Pérez, Jarmon G. Lees, Chrishan J. A. Ramachandra, Flavio F. Contreras-Torres, Anay Lázaro-Alfaro, Estefanía Luna-Figueroa, Judith Bernal-Ramírez, Aldemar Gordillo-Galeano, Alfredo Benitez, Yuriana Oropeza-Almazán, Elena C. Castillo, Poh Ling Koh, Derek J. Hausenloy, Shiang Y. Lim, Gerardo García-Rivas
Publikováno v:
Particle and Fibre Toxicology, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract Background Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been recently related to
Externí odkaz:
https://doaj.org/article/abb9fd431a344e3fa835135d83431615
Autor:
Lyujie Fang, Sandy S.C. Hung, Jennifer Yek, Layal El Wazan, Tu Nguyen, Shahnaz Khan, Shiang Y. Lim, Alex W. Hewitt, Raymond C.B. Wong
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 184-191 (2019)
Gain-of-function studies often require the tedious cloning of transgene cDNA into vectors for overexpression beyond the physiological expression levels. The rapid development of CRISPR/Cas technology presents promising opportunities to address these
Externí odkaz:
https://doaj.org/article/47be271b713e4be79fe2b7cfc5c1a5da
Autor:
Alison T. Merryweather-Clarke, David Cook, Barbara Joo Lara, Peng Hua, Emmanouela Repapi, Neil Ashley, Shiang Y. Lim, Suzanne M. Watt
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-15 (2018)
Abstract Background Human bone marrow-derived mesenchymal stem/stromal cells (hBM MSCs) have multiple functions, critical for skeletal formation and function. Their functional heterogeneity, however, represents a major challenge for their isolation a
Externí odkaz:
https://doaj.org/article/94b25ab97667484a9ffb4b23dc9ae9ea