Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Shian-Jang Yan"'
Autor:
Po-Jen Wu, Shian-Jang Yan
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Pseudomonas aeruginosa is a Gram-negative bacterium that causes severe infectious disease in diverse host organisms, including humans. Effective therapeutic options for P. aeruginosa infection are limited due to increasing multidr
Externí odkaz:
https://doaj.org/article/e94c389e6b7847349a737fd1426327e2
Autor:
Bin-Hsu Mao, Yi-Kai Luo, Bour-Jr Wang, Chun-Wan Chen, Fong-Yu Cheng, Yu-Hsuan Lee, Shian-Jang Yan, Ying-Jan Wang
Publikováno v:
Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-25 (2022)
Abstract Background Silver nanoparticles (AgNPs) are considered a double-edged sword that demonstrates beneficial and harmful effects depending on their dimensions and surface coating types. However, mechanistic understanding of the size- and coating
Externí odkaz:
https://doaj.org/article/af32ce5305ca45df9bcd1beb69a5d290
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Abstract High dietary sugar (HDS) is a modern dietary concern that involves excessive consumption of carbohydrates and added sugars, and increases the risk of metabolic disorders and associated cancers. However, epigenetic mechanisms by which HDS ind
Externí odkaz:
https://doaj.org/article/b874764ce448468e98bf7d3a6cffdc77
Autor:
Chia-Jung Yu, Dian W. Damaiyanti, Shian-Jang Yan, Chih-Hsing Wu, Ming-Jer Tang, Dar-Bin Shieh, Peter P. Liu, Ping-Yen Liu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13281 (2021)
Chronic kidney disease (CKD) is normally related to proteinuria, a common finding in a compromised glomerular filtration barrier (GFB). GFB is a structure composed of glomerular endothelial cells, the basement membrane, and the podocytes. CKD with po
Externí odkaz:
https://doaj.org/article/dc90c5366879412b9822c7d009791c9c
Autor:
Ching-Ying Wu, Wen-Li Hsu, Ming-Hsien Tsai, Jui-Lin Liang, Jian-He Lu, Chia-Jung Yen, Hsin-Su Yu, Mami Noda, Chi-Yu Lu, Chu-Huang Chen, Shian-Jang Yan, Tohru Yoshioka
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Based on the oxidative stress theory, aging derives from the accumulation of oxidized proteins induced by reactive oxygen species (ROS) in the cytoplasm. Hydrogen peroxide (H2O2) elicits ROS that induces skin aging through oxidation of prote
Externí odkaz:
https://doaj.org/article/c4b49102e8a541c6904ff2fe0fb745b0
Autor:
Wen-Li Hsu, Jian-He Lu, Mami Noda, Ching-Ying Wu, Jia-dai Liu, Manabu Sakakibara, Ming-Hsien Tsai, Hsin-Su Yu, Ming-Wei Lin, Yaw-Bin Huang, Shian-Jang Yan, Tohru Yoshioka
Publikováno v:
Molecules, Vol 20, Iss 11, Pp 20297-20311 (2015)
Ultraviolet-B (UVB) is one of the most cytotoxic and mutagenic stresses that contribute to skin damage and aging through increasing intracellular Ca2+ and reactive oxygen species (ROS). Derinat (sodium deoxyribonucleate) has been utilized as an immun
Externí odkaz:
https://doaj.org/article/d341c5ed0f644047ba6c8be400458cc1
Autor:
Zi-Yu Chen, Nian-Jhen Li, Fong-Yu Cheng, Jian-Feng Hsueh, Chiao-Ching Huang, Fu-I Lu, Tzu-Fun Fu, Shian-Jang Yan, Yu-Hsuan Lee, Ying-Jan Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2864 (2020)
As the worldwide application of nanomaterials in commercial products increases every year, various nanoparticles from industry might present possible risks to aquatic systems and human health. Presently, there are many unknowns about the toxic effect
Externí odkaz:
https://doaj.org/article/430f56e0b9d84cbdb9a1ce87103ae5c6
Autor:
Rong-Jane Chen, Yu-Ying Chen, Mei-Yi Liao, Yu-Hsuan Lee, Zi-Yu Chen, Shian-Jang Yan, Ya-Ling Yeh, Li-Xing Yang, Yen-Ling Lee, Yuan-Hua Wu, Ying-Jan Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2387 (2020)
Nanotechnology has rapidly promoted the development of a new generation of industrial and commercial products; however, it has also raised some concerns about human health and safety. To evaluate the toxicity of the great diversity of nanomaterials (
Externí odkaz:
https://doaj.org/article/ea01701f7ef5447a864e4db83b67ea06
Autor:
Kimberly Larson, Shian-Jang Yan, Amy Tsurumi, Jacqueline Liu, Jun Zhou, Kriti Gaur, Dongdong Guo, Thomas H Eickbush, Willis X Li
Publikováno v:
PLoS Genetics, Vol 8, Iss 1, p e1002473 (2012)
Organismal aging is influenced by a multitude of intrinsic and extrinsic factors, and heterochromatin loss has been proposed to be one of the causes of aging. However, the role of heterochromatin in animal aging has been controversial. Here we show t
Externí odkaz:
https://doaj.org/article/ab7f66a9752240d09fe389e1f031fe0d
Autor:
Fan Xia, Jinghong Li, Gavin W Hickey, Amy Tsurumi, Kimberly Larson, Dongdong Guo, Shian-Jang Yan, Louis Silver-Morse, Willis X Li
Publikováno v:
PLoS Biology, Vol 6, Iss 5, p e128 (2008)
The proto-oncoprotein Raf is pivotal for mitogen-activated protein kinase (MAPK) signaling, and its aberrant activation has been implicated in multiple human cancers. However, the precise molecular mechanism of Raf activation, especially for B-Raf, r
Externí odkaz:
https://doaj.org/article/4036ce6e4cc642a2b53bb3176313e2a3