Zobrazeno 1 - 10 of 93 pro vyhledávání: '"Shian-Jang Yan"'
1
Akademický článek
HP1a-mediated heterochromatin formation promotes antimicrobial responses against Pseudomonas aeruginosa infection
Autor: Po-Jen Wu, Shian-Jang Yan
Publikováno v: BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Pseudomonas aeruginosa is a Gram-negative bacterium that causes severe infectious disease in diverse host organisms, including humans. Effective therapeutic options for P. aeruginosa infection are limited due to increasing multidr
Externí odkaz: https://doaj.org/article/e94c389e6b7847349a737fd1426327e2
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2
Akademický článek
Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo
Autor: Bin-Hsu Mao, Yi-Kai Luo, Bour-Jr Wang, Chun-Wan Chen, Fong-Yu Cheng, Yu-Hsuan Lee, Shian-Jang Yan, Ying-Jan Wang
Publikováno v: Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-25 (2022)
Abstract Background Silver nanoparticles (AgNPs) are considered a double-edged sword that demonstrates beneficial and harmful effects depending on their dimensions and surface coating types. However, mechanistic understanding of the size- and coating
Externí odkaz: https://doaj.org/article/af32ce5305ca45df9bcd1beb69a5d290
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3
Akademický článek
HP1a-mediated heterochromatin formation inhibits high dietary sugar-induced tumor progression
Autor: Che-Wei Chang, Yu-Chia Shen, Shian-Jang Yan
Publikováno v: Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Abstract High dietary sugar (HDS) is a modern dietary concern that involves excessive consumption of carbohydrates and added sugars, and increases the risk of metabolic disorders and associated cancers. However, epigenetic mechanisms by which HDS ind
Externí odkaz: https://doaj.org/article/b874764ce448468e98bf7d3a6cffdc77
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4
Akademický článek
The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes
Autor: Chia-Jung Yu, Dian W. Damaiyanti, Shian-Jang Yan, Chih-Hsing Wu, Ming-Jer Tang, Dar-Bin Shieh, Peter P. Liu, Ping-Yen Liu
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 24, p 13281 (2021)
Chronic kidney disease (CKD) is normally related to proteinuria, a common finding in a compromised glomerular filtration barrier (GFB). GFB is a structure composed of glomerular endothelial cells, the basement membrane, and the podocytes. CKD with po
Externí odkaz: https://doaj.org/article/dc90c5366879412b9822c7d009791c9c
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5
Akademický článek
Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress
Autor: Ching-Ying Wu, Wen-Li Hsu, Ming-Hsien Tsai, Jui-Lin Liang, Jian-He Lu, Chia-Jung Yen, Hsin-Su Yu, Mami Noda, Chi-Yu Lu, Chu-Huang Chen, Shian-Jang Yan, Tohru Yoshioka
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Based on the oxidative stress theory, aging derives from the accumulation of oxidized proteins induced by reactive oxygen species (ROS) in the cytoplasm. Hydrogen peroxide (H2O2) elicits ROS that induces skin aging through oxidation of prote
Externí odkaz: https://doaj.org/article/c4b49102e8a541c6904ff2fe0fb745b0
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