Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Shian-Huey Chiang"'
Autor:
Shian-Huey Chiang, W Wallace Harrington, Guizhen Luo, Naphtali O Milliken, John C Ulrich, Jing Chen, Deepak K Rajpal, Ying Qian, Tiffany Carpenter, Rusty Murray, Robert S Geske, Stephen A Stimpson, Henning F Kramer, Curt D Haffner, J David Becherer, Frank Preugschat, Andrew N Billin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134927 (2015)
Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis. Intrac
Externí odkaz:
https://doaj.org/article/6c250288d3cf48f0b41fe25918c4ad63
Autor:
Jonathan Mowers, Maeran Uhm, Shannon M Reilly, Joshua Simon, Dara Leto, Shian-Huey Chiang, Louise Chang, Alan R Saltiel
Publikováno v:
eLife, Vol 2 (2013)
Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipo
Externí odkaz:
https://doaj.org/article/98634cc3740a496c95b305f3ae070aec
Autor:
Mohammed Alsuraih, Brianna LaViolette, Guan-Yu Lin, Ramesh Kovi, Natalie Daurio, Congsheng Cheng, Youngwook Ahn, Zhihua Jiang, Roberto Ortiz, Shangzhong Li, Yuxing Cheng, Ye Wang, Xiaoyu Fan, Jessica Haskins, Xiuhua Sun, Abigail Hunter, Dinesh Hirenallur Shanthapa, Ying Wu, Matthew Holsti, Morag Stewart, Marija Tadin-Strapps, Shian-Huey Chiang
Mutations in the ABCB4 gene lead to a wide-spectrum of rare liver diseases including progressive familial intrahepatic cholestasis type 3 (PFIC3) and low-phospholipid associated cholelithiasis (LPAC) syndrome. PFIC3 patients develop symptoms during l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a871d396d3b62271fa31c94b20fa7208
https://doi.org/10.1101/2023.04.11.535868
https://doi.org/10.1101/2023.04.11.535868
Publikováno v:
The Journal of Immunology. 204:217.18-217.18
Inflammatory bowel diseases are associated with a loss of epithelial barrier integrity that can lead to an imbalance in gut homeostasis and severe inflammation. Studies in mice have shown that CD1d, a lipid antigen-presenting molecule, and natural ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ed58194ac38833110eca75a17fa1f50
https://doi.org/10.4049/jimmunol.204.supp.217.18
https://doi.org/10.4049/jimmunol.204.supp.217.18
Autor:
Merlijn Bazuine, Sheelarani Karunanithi, Maeran Uhm, Tingting Xiong, Louise Chang, Alan R. Saltiel, Shian Huey Chiang, Peng Zhao
Publikováno v:
Science signaling. 10(471)
Insulin stimulates glucose uptake through the translocation of the glucose transporter GLUT4 to the plasma membrane. The exocyst complex tethers GLUT4-containing vesicles to the plasma membrane, a process that requires the binding of the G protein (h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3960aaf1825c0fce173fa51ffa614b2a
https://pubmed.ncbi.nlm.nih.gov/28325821
https://pubmed.ncbi.nlm.nih.gov/28325821
Autor:
Takuhito Sezaki, Kazumitsu Ueda, Tomohiko Araki, Alan R. Saltiel, Shinji Deguchi, Noriyuki Kioka, Takafumi Ichikawa, Masahiro Kita, Ayaka Ichikawa Nagasato, Shian Huey Chiang, Tsubasa S. Matsui, Yasuhisa Kimura
Publikováno v:
Journal of cell science. 130(20)
Vinexin, c-Cbl associated protein (CAP) and Arg-binding protein 2 (ArgBP2) constitute an adaptor protein family called the vinexin (SORBS) family that is targeted to focal adhesions (FAs). Although numerous studies have focused on each of the SORBS p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcfd51bdaf8e91ed0032474df4a432c
https://pubmed.ncbi.nlm.nih.gov/28864765
https://pubmed.ncbi.nlm.nih.gov/28864765
Autor:
Irit Hochberg, Pingping Li, John R. Rubin, Jonathan Mowers, Shannon M. Reilly, Alan R. Saltiel, Shian Huey Chiang, Ronald M. Evans, Da Young Oh, Stuart J. Decker, Christopher Liddle, Ruth T. Yu, Michael Downes, Louise Chang, Jerrold M. Olefsky, Martha J. Larsen, Maeran Uhm, Nicole M. White
Publikováno v:
Nature Medicine. 19:313-321
Alan Saltiel and his colleagues report that the approved drug amlexanox, currently used to treat asthma and canker sores, is a relatively specific inhibitor of the noncanonical IκB kinases IKK-ɛ and TANK-binding kinase 1 (TBK1) and that it improves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ab7cc33dfa68a8865cdcbfa49e6d80d
https://doi.org/10.1038/nm.3082
https://doi.org/10.1038/nm.3082
Autor:
Jennifer B. DelProposto, Jonathan Mowers, Fiona E. Yull, Jie Zhou, Alan R. Saltiel, Daniel J. Westcott, Merlijn Bazuine, Nicole M. White, Timothy S. Blackwell, Carey N. Lumeng, Shian Huey Chiang, Jing Tyan Ma, Nathan Qi, Lynn M. Geletka
Publikováno v:
Cell. 138(5):961-975
Obesity is associated with chronic low-grade inflammation that negatively impacts insulin sensitivity. Here, we show that high-fat diet can increase NF-kappaB activation in mice, which leads to a sustained elevation in level of IkappaB kinase epsilon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbb345263df2233b331e7fdf76033bd
Publikováno v:
Developmental Cell. 13:391-404
Insulin stimulates glucose transport in muscle and adipose tissue by producing translocation of the glucose transporter Glut4. The exocyst, an evolutionarily conserved vesicle tethering complex, is crucial for targeting Glut4 to the plasma membrane.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597bee2630444f8f851800f85a2bcb87
https://doi.org/10.1016/j.devcel.2007.07.007
https://doi.org/10.1016/j.devcel.2007.07.007
Autor:
Sona Kang, Wendy S. Wright, Ormond A. MacDougald, Vedrana S. Susulic, Tyler C. Prestwich, Vernon W. Dolinsky, Kenneth A. Longo, Shian Huey Chiang, Christina N. Bennett, Isabelle Gerin, Charles F. Burant, Catherine Gress
Publikováno v:
Diabetes. 56:295-303
The Wnt family of secreted signaling molecules has profound effects on diverse developmental processes, including the fate of mesenchymal progenitors. While activation of Wnt signaling blocks adipogenesis, inhibition of endogenous Wnt/beta-catenin si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79b4e914c0b9e82ff785510137d9653
https://doi.org/10.2337/db06-1339
https://doi.org/10.2337/db06-1339