Zobrazeno 1 - 10
of 219
pro vyhledávání: '"ShiWu Li"'
Autor:
Shiwu Li, Changguo Ma, Yifan Li, Rui Chen, Yixing Liu, Li Pear Wan, Qiuxia Xiong, Chuang Wang, Yongxia Huo, Xinglun Dang, Yongfeng Yang, Luxian Lv, Xi Chen, Nengyin Sheng, Wenqiang Li, Xiong-Jian Luo
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The missense variant rs13107325 (C/T, p.Ala391Thr) in SLC39A8 consistently showed robust association with schizophrenia in recent genome-wide association studies (GWASs), suggesting the potential pathogenicity of this non-synonymous risk var
Externí odkaz:
https://doaj.org/article/b00f5596114d497d98229245a2eff30e
Autor:
Rui Chen, Jiewei Liu, Shiwu Li, Xiaoyan Li, Yongxia Huo, Yong-Gang Yao, Xiao Xiao, Ming Li, Xiong-Jian Luo
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucidating their roles in
Externí odkaz:
https://doaj.org/article/903a6fb3fbbe4cf59705ec86a9b109a1
Autor:
William Donelan, ShiWu Li, Paul R Dominguez-Gutierrez, Augustus Anderson Iv, Li-Jun Yang, Cuong Nguyen, Benjamin K Canales
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285556 (2023)
Oxalate oxidase is an enzyme that degrades oxalate and is used in commercial urinary assays to measure oxalate levels. The objective of this study was to establish an enhanced expression system for secretion and purification of oxalate oxidase using
Externí odkaz:
https://doaj.org/article/88053d4c1ecd4a08929acf9ca5e0d4e0
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Non-alcoholic Fatty Liver Disease (NAFLD) is a chronic liver disease that is strongly related to insulin resistance and metabolic syndrome, and it has become the most common liver disorder in developed countries. NAFLD embraces the full pathological
Externí odkaz:
https://doaj.org/article/a57966a7e6b64ff69ac75c1d9829271f
Autor:
Jiewei Liu, Shiwu Li, Xiaoyan Li, Wenqiang Li, Yongfeng Yang, Suqin Guo, Luxian Lv, Xiao Xiao, Yong-Gang Yao, Fanglin Guan, Ming Li, Xiong-Jian Luo
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background Over 200 schizophrenia risk loci have been identified by genome-wide association studies (GWASs). However, the majority of risk loci were identified in populations of European ancestry (EUR), potentially missing important biologic
Externí odkaz:
https://doaj.org/article/fc9fe80d0f57443b8c33029d9308ee96
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
FNDC5 is the precursor of the myokine irisin proposed to exhibit favorable metabolic activity, including anti-obesity and anti-diabetes effects. The diversity of FNDC5 transcripts has been reported by several studies, but the role and existence of th
Externí odkaz:
https://doaj.org/article/2c69615fd7ee4bb485430a18f22410f5
Autor:
Yifan Li, Changguo Ma, Shiwu Li, Junyang Wang, Wenqiang Li, Yongfeng Yang, Xiaoyan Li, Jiewei Liu, Jinfeng Yang, Yixing Liu, Kaiqin Li, Jiao Li, Di Huang, Rui Chen, Luxian Lv, Xiao Xiao, Ming Li, Xiong‐Jian Luo
Publikováno v:
Advanced Science, Vol 9, Iss 6, Pp n/a-n/a (2022)
Abstract Genome‐wide association studies have identified 3p21.1 as a robust risk locus for schizophrenia. However, the underlying molecular mechanisms remain elusive. Here a functional regulatory variant (rs2535629) is identified that disrupts CTCF
Externí odkaz:
https://doaj.org/article/62b5235d18a44da7a3e4343db9726f6d
Publikováno v:
International Journal of Photoenergy, Vol 2022 (2022)
The integration of solar photovoltaic (PV) power generation technology into electric vehicle (EV) charging systems is of great significance, and it is very important to analyze the influencing factors of vehicle operating parameters on the generation
Externí odkaz:
https://doaj.org/article/8fb0b452d99046c8bc794455f886417f
Autor:
Hui Li, William Donelan, Fang Wang, Peilan Zhang, Lijun Yang, Yousong Ding, Dongqi Tang, Shiwu Li
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Multiple GLP-1-derived therapeutics are clinically used to treat type 2 diabetes and obesity. However, the underlying mechanism of how these drugs regulate the body weight of obese patients remains incompletely understood. Here, we report that the li
Externí odkaz:
https://doaj.org/article/7bdb554328d646d6b1fcf7fdac2da5a2
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
We know a large number of risk SNPs for schizophrenia, but little about how these SNPs contribute to the disorder. Here, the authors use functional genomics to identify risk SNPs that disrupt transcription factor binding and validate the regulatory e
Externí odkaz:
https://doaj.org/article/84007106e80b429e9d5b74bc356226ca