Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Shi-qiong Yang"'
Autor:
Qiu-Qin He, Xiao-Dong Ma, Xuan Zhang, Liu-Meng Yang, Shuang-Xi Gu, Hui-Fang Dai, Fen-Er Chen, Yong-Tang Zheng, Shi-Qiong Yang
Publikováno v:
European Journal of Medicinal Chemistry. 58:504-512
A series of N -phenylarylformamide derivatives (PAFAs) with anti-wild-type HIV-1 activity (EC 50 values) ranging from 0.3 nM to 5.1 nM and therapeutic index (TI) ranging from 10 616 to 271 000 were identified as novel non-nucleoside reverse transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8818ee41e92b88ad693f769879beac86
https://doi.org/10.1016/j.ejmech.2012.03.032
https://doi.org/10.1016/j.ejmech.2012.03.032
Publikováno v:
Current Medicinal Chemistry. 19:152-162
Numerous structurally different non-nucleoside compounds have been evaluated for their inhibitory effects against HIV replication, in which DABO derivatives, bearing the dihydro-alkoxyl-benzyl-oxopyrimidine scaffold, have been identified as a particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3f46320f06765a7bfe886d1986dd36
https://doi.org/10.2174/092986712803414169
https://doi.org/10.2174/092986712803414169
Autor:
Qiu-Qin He, Fen-Er Chen, Erik De Clercq, Shi-Qiong Yang, Xiao-Dong Ma, Jan Balzarini, Shuang-Xi Gu, Christophe Pannecouque
Publikováno v:
ChemMedChem. 6:2225-2232
A series of novel diarylpyrimidines (DAPYs) with a ketone hydrazone substituent on the methylene linker between the pyrimidine nucleus and the aryl moiety at the C-4 position were synthesized, and their antiviral activity against human immunodeficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f92e508af2cef28be9275116a3d1b8
https://doi.org/10.1002/cmdc.201100334
https://doi.org/10.1002/cmdc.201100334
Autor:
Piet Herdewijn, Shi-Qiong Yang
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 30:597-608
Nucleoside triphosphate mimetics, which are substrates for polymerases, can be used in the enzymatic synthesis of nucleic acids. Alternatively, they might also become reversible or irreversible enzyme inhibitors. In order to analyze the effects of 5'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1315cb1adc6fa2ca14caa0fff43fed48
https://doi.org/10.1080/15257770.2011.598491
https://doi.org/10.1080/15257770.2011.598491
Autor:
Qiu-Qin He, Shuang-Xi Gu, Liu-Meng Yang, Yong-Tang Zheng, Xuan Zhang, Xiao-Dong Ma, Fen-Er Chen, Shi-Qiong Yang
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:4220-4226
A novel series of naphthyl phenyl ether analogues (NPEs) have been synthesized and evaluated for their in vitro activities against HIV in C8166 cells. Most of the compounds exhibited moderate to excellent anti-HIV activities. Among them the most acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d359c5f56a00458d6ffdecf1720c9de6
https://doi.org/10.1016/j.bmc.2011.05.060
https://doi.org/10.1016/j.bmc.2011.05.060
Publikováno v:
Tetrahedron
The synthesis of N-methyl-d-ribopyranuronamide nucleosides is described. The key route is the rearrangement of a 1,2-O-isopropylidene protected furanose sugar with a carboxamide function in the 4-position to a ribopyranuronamide ring. The Lewis acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2945dbd6ebedf612614bcb263a99eed3
http://europepmc.org/articles/PMC7126205
http://europepmc.org/articles/PMC7126205
Publikováno v:
Synlett. 23:948-950
Enantioselective asymmetric N-nitrosoaldol reaction of tertiary β-carbonyl esters using thebifunctional squaramide organanocatalysts is described. These adductshave been obtained in moderate yields and with up to 98% ee.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c420ba367b8f70b0382595fe4475733
https://doi.org/10.1055/s-0031-1290613
https://doi.org/10.1055/s-0031-1290613
Publikováno v:
Journal of Chemical Research; Feb2018, Vol. 42 Issue 2, p105-108, 4p
Autor:
Erik De Clercq, Christophe Pannecouque, Fen-Er Chen, Shi-Qiong Yang, Xiao-Dong Ma, Dirk Daelemans, Yang Liu
Publikováno v:
European journal of medicinal chemistry. 65
This paper reports the synthesis and antiviral evaluation of a series of non-nucleoside reverse transcriptase inhibitors (NNRTIs) that combine the peculiar structural features of diarylpyrimidine derivatives (DAPYs) and benzophenone derivatives (BPs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49d424f64dfba14461fb3f4b476a6e1
https://pubmed.ncbi.nlm.nih.gov/23707918
https://pubmed.ncbi.nlm.nih.gov/23707918
A series of d4T di- or triphosphate derivatives have been synthesized and evaluated as effective substrates for HIV-1 RT, and also tested for their in vitro anti-HIV activity. The steady-state kinetic study of compounds 1-4 in an enzymatic incorporat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326242bc86a1d84ca0b32ae985c07db9
https://lirias.kuleuven.be/handle/123456789/361385
https://lirias.kuleuven.be/handle/123456789/361385
