Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Shi-ming XU"'
Autor:
Si-Cheng Liu, Yi-Li Feng, Xiu-Na Sun, Ruo-Dan Chen, Qian Liu, Jing-Jing Xiao, Jin-Na Zhang, Zhi-Cheng Huang, Ji-Feng Xiang, Guo-Qiao Chen, Yi Yang, Chao Lou, Hao-Dan Li, Zhen Cai, Shi-Ming Xu, Hui Lin, An-Yong Xie
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-32 (2022)
Abstract Background Due to post-cleavage residence of the Cas9-sgRNA complex at its target, Cas9-induced DNA double-strand breaks (DSBs) have to be exposed to engage DSB repair pathways. Target interaction of Cas9-sgRNA determines its target binding
Externí odkaz:
https://doaj.org/article/3baeafdd016e47d9820a0acff3a8a5a0
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Tetrahydro-γ-carbolines are the basic structural unit in many natural products and pharmaceuticals. Here, the authors report a synergistic Cu/Ir system to assemble chiral tetrahydro-γ-carbolines via a stereodivergent allylation followed by a stereo
Externí odkaz:
https://doaj.org/article/e79dc2021cf04aeb843a77e7163965de
Publikováno v:
Journal of Marine Science and Engineering, Vol 10, Iss 10, p 1515 (2022)
For the design of a horizontal-axis tidal current turbine with adaptive variable-pitch blades, both numerical simulations and physical model experiments were used to study the hydrodynamic performance of symmetrical airfoil blades based on backward s
Externí odkaz:
https://doaj.org/article/5aef73de0aee48938f572e0ee541727e
Publikováno v:
Tongxin xuebao, Vol 38, Pp 76-85 (2017)
Loop distribution of Tanner graph affects the BER performance of low-density parity-check codes(LDPC) decoding.To count short cycles in the Tanner graph efficiently,a side by side recursion algorithm based on matrix computation was proposed.Firstly,5
Externí odkaz:
https://doaj.org/article/7328c3a3d2e443b48a3a3018fba5fd67
Autor:
Ming Xu, Peng Zhou, Shi-Ming Xu, Yin Liu, Xinheng Feng, Shu-Hua Bai, Yan Bai, Xue-Mei Hao, Qide Han, Youyi Zhang, Shi-Qiang Wang
Publikováno v:
PLoS Biology, Vol 5, Iss 2, p e21 (2007)
Pressure overload-induced hypertrophy is a key step leading to heart failure. The Ca(2+)-induced Ca(2+) release (CICR) process that governs cardiac contractility is defective in hypertrophy/heart failure, but the molecular mechanisms remain elusive.
Externí odkaz:
https://doaj.org/article/35ca7cafa33e4b63946bec55f5d574df
Publikováno v:
Organic Letters. 23:706-710
Ir-catalyzed asymmetric tandem allylation/iso-Pictet-Spengler cyclization of arylidenaminomalonates with indolyl allylic methyl carbonates was successfully developed, which provided a direct and practical approach to access synthetically useful and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66120ff00060c4e4a82d3221661825f8
https://doi.org/10.1021/acs.orglett.0c03909
https://doi.org/10.1021/acs.orglett.0c03909
Autor:
An-Yong Xie, Si-Cheng Liu, Yi-Li Feng, Xiu-Na Sun, Ruo-Dan Chen, Qian Liu, Jing-Jing Xiao, Ji-Feng Xiang, Guo-Qiao Chen, Yi Yang, Chao Lou, Hao-Dan Li, Shi-Ming Xu, Hui Lin
Given its different target-binding affinity and varying residence time after DNA cleavage, the Cas9-sgRNA complex that remains bound to cleaved DNA may influence DNA double strand break (DSB) repair pathway choices, contributing to highly heterogeneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::806dc7ee7b34d6949f99347db97ca9c1
https://doi.org/10.21203/rs.3.rs-266312/v1
https://doi.org/10.21203/rs.3.rs-266312/v1
Autor:
An-Yong Xie, Si-Cheng Liu, Yi-Li Feng, Xiu-Na Sun, Ruo-Dan Chen, Qian Liu, Jing-Jing Xiao, Ji-Feng Xiang, Guo-Qiao Chen, Yi Yang, Chao Lou, Hao-Dan Li, Shi-Ming Xu, Hui Lin
Background Due to post-cleavage residence of the Cas9-sgRNA complex at its target, Cas9-induced DNA double strand breaks (DSBs) have to be exposed in order to engage DSB repair pathways. Target interaction of Cas9-sgRNA determines its target-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f71495a85c41b41cb3181d3d42159788
https://doi.org/10.21203/rs.3.rs-764726/v1
https://doi.org/10.21203/rs.3.rs-764726/v1
Publikováno v:
Chemical Communications. 56:9691-9694
Here, we developed an expedient access route to highly functionalized pyrroles from readily available α-amino acid ester hydrochlorides and alkynals via a cascade condensation/intramolecular cyclization followed by a unique C-N ester migration proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19ca560d1a39d537f6db2a04c63d425
https://doi.org/10.1039/d0cc02964e
https://doi.org/10.1039/d0cc02964e
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Enantiomerically enriched indole-containing heterocycles play a vital role in bioscience, medicine, and chemistry. As one of the most attractive subtypes of indole alkaloids, highly substituted tetrahydro-γ-carbolines are the basic structural unit i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8b7ec90bb68ad6fd1aa945ec411cf9
http://link.springer.com/article/10.1038/s41467-019-13529-z
http://link.springer.com/article/10.1038/s41467-019-13529-z