Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Shi-min Zhao"'
Autor:
Qing Shi, Yasheng Zhu, Jian Ma, Kun Chang, Dongling Ding, Yang Bai, Kun Gao, Pingzhao Zhang, Ren Mo, Kai Feng, Xiaying Zhao, Liang Zhang, Huiru Sun, Dongyue Jiao, Yingji Chen, Yinghao Sun, Shi-min Zhao, Haojie Huang, Yao Li, Shancheng Ren, Chenji Wang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/b6ce4902fa8f48309ab9761443684c09
Autor:
Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-Xin Yang, Zhen-Zhen Ma, Lin Huang, Yan-Peng An, Yi-Yuan Yuan, Yan Lin, Wei Xu, Yao Li, Peng-Cheng Lin, Jing Cao, Jian-Yuan Zhao, Shi-Min Zhao
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-20 (2024)
Abstract Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which the KD exerts its antiepileptic efficacy remain elusive. Herein, we report that KD-produced β-hydr
Externí odkaz:
https://doaj.org/article/66a3313a39f2455fb88f19ab0b6eebf7
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Background: Ubiquitination and deubiquitination modifications play pivotal roles in eukaryotic life processes, regulating protein dynamics via the ubiquitin-proteasome pathway. Dysregulation can impact disease development, including cancer and neurod
Externí odkaz:
https://doaj.org/article/86b02fd7b08f436eb74c27b718664fa4
Autor:
Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-Xin Yang, Zhen-Zhen Ma, Lin Huang, Yan-Peng An, Yi-Yuan Yuan, Yan Lin, Wei Xu, Yao Li, Peng-Cheng Lin, Jing Cao, Jian-Yuan Zhao, Shi-Min Zhao
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/9656a211a89e400e9a5115224e93da00
Autor:
Qian Zhou, Wan-Wan Sun, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Whether amino acids act on cellular insulin signaling remains unclear. Here, the authors find that phenylalanine modifies insulin receptor beta (IRβ) and inactivates insulin signaling and glucose uptake and positively correlated with T2D onset.
Externí odkaz:
https://doaj.org/article/e9376a4fdc444325870bdfde7eed1fc8
Autor:
Rui Zhao, Ke Cai, Jing-Jing Yang, Qian Zhou, Wei Cao, Jie Xiang, Yi-Hui Shen, Lei-Lei Cheng, Wei-Dong Zang, Yan Lin, Yi-Yuan Yuan, Wei Xu, Hui Tao, Shi-Min Zhao, Jian-Yuan Zhao
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112400- (2023)
Summary: Dysregulated amino acid increases the risk for heart failure (HF) via unclear mechanisms. Here, we find that increased plasma tyrosine and phenylalanine levels are associated with HF. Increasing tyrosine or phenylalanine by high-tyrosine or
Externí odkaz:
https://doaj.org/article/43ba1906776541b1b50ade26663d94c9
Autor:
Jianong Zhang, Kun Gao, Hongyan Xie, Dejie Wang, Pingzhao Zhang, Ting Wei, Yuqian Yan, Yunqian Pan, Wenbin Ye, Huifen Chen, Qing Shi, Yao Li, Shi-min Zhao, Xiaonan Hou, Saravut J. Weroha, Yuzhuo Wang, Jun Zhang, R. Jeffrey Karnes, Housheng Hansen He, Liguo Wang, Chenji Wang, Haojie Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The molecular mechanism underlying the DNA hypermethylation phenotype observed in the SPOP-mutant prostate cancers is unclear. Here, the authors show that mutant SPOP induces global aberrant DNA methylation patterns through GLP/G9a and renders prosta
Externí odkaz:
https://doaj.org/article/db75dbabc63044e4b2c4d83423549287
Autor:
Liang Zhang, Jianong Zhang, Yan Liu, Pingzhao Zhang, Ji Nie, Rui Zhao, Qin Shi, Huiru Sun, Dongyue Jiao, Yingji Chen, Xiaying Zhao, Yan Huang, Yao Li, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao, Chenji Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-12 (2021)
Abstract Signal transducer and activator 5a (STAT5A) is a classical transcription factor that plays pivotal roles in various biological processes, including tumor initiation and progression. A fraction of STAT5A is localized in the mitochondria, but
Externí odkaz:
https://doaj.org/article/977230dcb33c4551a42e1a6230c8e22e
Autor:
Xiao-Hui Wang, Sha Xu, Xiang-Yu Zhou, Rui Zhao, Yan Lin, Jing Cao, Wei-Dong Zang, Hui Tao, Wei Xu, Ming-Qing Li, Shi-Min Zhao, Li-Ping Jin, Jian-Yuan Zhao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Abnormal placentation is associated with recurrent spontaneous abortion (RSA) risk. Here the authors report that low embryonic villous succinate level associates with risk of RSA in patients, and increasing succinate levels is sufficient to reduce th
Externí odkaz:
https://doaj.org/article/554bcb641b204c6ea4a02f1be0c6e985
Autor:
Hui‐Lu Zhang, Ping Chen, He‐Xin Yan, Gong‐Bo Fu, Fei‐Fei Luo, Jun Zhang, Shi‐Min Zhao, Bo Zhai, Jiang‐Hong Yu, Lin Chen, Hao‐Shu Cui, Jian Chen, Shuai Huang, Jun Zeng, Wei Xu, Hong‐Yang Wang, Jie Liu
Publikováno v:
Advanced Science, Vol 9, Iss 20, Pp n/a-n/a (2022)
Abstract Cancer cells are addicted to glutamine. However, cancer cells often suffer from glutamine starvation, which largely results from the fast growth of cancer cells and the insufficient vascularization in the interior of cancer tissues. Herein,
Externí odkaz:
https://doaj.org/article/81f02619edc94292b06a9ec82b43aa4d