Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shi-Xian Cao"'
Autor:
Thorsten U. Vogel, Ray Oomen, Danielle Salha, Neil L. Berinstein, Corey Lovitt, Tao Wen, Mark Parrington, Linong Zhang, Mei Tang, Lucian Visan, Bryan McNeil, Bill Bradley, Judy Caterini, Devender Sandhu, Belma Ljutic, Nancy Scollard, Shi-Xian Cao, Liwei He, Pamela Dunn, Jim Tartaglia, Beata Gajewska
Publikováno v:
Journal of Immunotherapy. 33:743-758
New therapies are urgently required for the treatment of patients with melanoma. Here we describe the generation and preclinical evaluation of 3 new recombinant ALVAC(2) poxviruses vCP2264, vCP2291, and vCP2292 for their ability to induce the desired
Autor:
Benjamin Rovinski, Michel H. Klein, Thomas J. Matthews, Shi-Xian Cao, Roy Persson, Gregory A. Dekaban, Fei-Long Yao
Publikováno v:
Virology. 257(2):438-448
Many AIDS vaccine candidates under development may elicit immune responses similar to those observed in and used to screen human immunodeficiency virus type 1 (HIV-1)-infected individuals. Therefore, it is important to develop vaccine candidates that
Publikováno v:
Journal of Virology. 73:2309-2320
Retroviral Gag proteins, in the absence of any other viral products, induce budding and release of spherical, virus-like particles from the plasma membrane. Gag-produced particles, like those of authentic retrovirions, are not uniform in diameter but
Publikováno v:
Scopus-Elsevier
The retroviral Gag protein plays the central role in the assembly process and can form membrane-enclosed, virus-like particles in the absence of any other viral products. These particles are similar to authentic virions in density and size. Three sma
Autor:
Michel Klein, Thomas J. Matthews, Joel R. Haynes, Susan Zolla-Pazner, Shi Xian Cao, O. James, Charles Sia, Benjamin Rovinski
Publikováno v:
Journal of Virology. 66:4003-4012
Noninfectious human immunodeficiency virus type 1 (HIV-1) viruslike particles containing chimeric envelope glycoproteins were expressed in mammalian cells by using inducible promoters. We engineered four expression vectors in which a synthetic oligom
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 26(4)
HIV-1 retrovirus-like particles can be produced in VERO cells that have been transfected with an expression construct encoding HIV-1 structural proteins. The particles are entirely non-infectious although structurally they resemble infectious virus p
Autor:
Michel H. Klein, Susan Zolla-Pazner, Charles Sia, John R. Mascola, Lauren Rodrigues, Ursula McGuinness, George A. Cates, S. Karwowska, Fei-Long Yao, Shi Xian Cao, Benjamin Rovinski, Charlene McDanal, Thomas J. Matthews
Publikováno v:
AIDS research and human retroviruses. 11(10)
Genetically engineered, noninfectious HIV-1-like particles containing processed envelope glycoproteins represent potential candidate immunogens for a vaccine against HIV-1. However, since the gp120 glycoprotein is known to be rapidly lost from the su
Publikováno v:
Gene. 110(2)
To clarify the molecular mechanisms involved in the developmental control of hemoglobin-encoding genes we have been studying the expression of these genes in human cells in continuous culture. We have previously reported the presence of a transcripti
Publikováno v:
Molecular immunology. 28(3)
The production of genetically-engineered, noninfectious virions of human immunodeficiency virus (HIV) represents a novel approach to the development of a safe and effective vaccine for the acquired immune deficiency syndromes (AIDS). Insofar as prepa
Autor:
Benjamin Rovinski, Shi Xian Cao, Gregory A. Dekaban, Olive James, Michel H. Klein, Joel R. Haynes, Charles Sia
Publikováno v:
AIDS research and human retroviruses. 7(1)
A proviral fragment from human immunodeficiency virus type 1 (HIV-1) (LAV-1BRU) containing only protein-coding information, was expressed in COS cells using constitutive promoters in transient and stable transfection experiments. The presence of viru