Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Shi-Wu Chen"'
Autor:
Xiao-Guang Zhang, Jing-Yu Gu, Qiang-Qiang Fu, Shi-Wu Chen, Jie Xue, Shan-Shan Jiang, Yu-Ming Kong, You-Mei Li, Yun-Hua Yue
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Platelet endothelial aggregation receptor-1 (PEAR1) rs12041331 has been reported to affect agonist-stimulated platelet aggregation, but it remains unclear whether this variant plays a role in recurrent stroke. Here we assess the clinical
Externí odkaz:
https://doaj.org/article/3924a2c8425e4d3b836816a8bf42e52e
Publikováno v:
Molecules, Vol 15, Iss 1, Pp 138-148 (2009)
Camptothecin (CPT), a traditional anti-tumor drug, has been shown to possess anti-HIV-1 activity. To increase the antiviral potency, the anti-HIV activities of two CPT derivatives, 10-hydroxy-CPT and 7-hydroxymethyl-CPT, were evaluated in vitro. The
Externí odkaz:
https://doaj.org/article/3a63b70008aa4916bda515a7d99ccbc3
Akademický článek
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Autor:
Xing-Rong Wang, Shuai Wang, Hong-Xia Mu, Kai-Yan Xu, Xue-Ting Wang, Jian-Tao Shi, Qi-Hang Cui, Li-Wen Zhang, Shi-Wu Chen
Publikováno v:
European journal of medicinal chemistry. 244
VEGFR-2 is an attractive therapeutic target for antitumor drug research by blocking tumor angiogenesis and PROTAC provides a new technology for targeted protein knockout. Herein, a library of novel VEGFR-2-PROTAC degraders were rationally designed an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888155ae42f81dbf6c3eba31bc4eb0bd
https://pubmed.ncbi.nlm.nih.gov/36242985
https://pubmed.ncbi.nlm.nih.gov/36242985
Autor:
Shi-Wu Chen, Xue-Li Jing
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:625-643
Aurora kinases are a family of serine/threonine kinases, and promote mitotic spindle assembly by regulating centrosome duplication and separation. Aurora kinases are overexpressed in a variety of...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b660e2de6b76784f9ae43604d4eb717
https://doi.org/10.1080/13543776.2021.1890027
https://doi.org/10.1080/13543776.2021.1890027
Autor:
Xiu-Juan Liu, Hong-Cheng Zhao, Su-Juan Hou, Hao-Jie Zhang, Lei Cheng, Shuo Yuan, Li-Rong Zhang, Jian Song, Sai-Yang Zhang, Shi-Wu Chen
Publikováno v:
Bioorganic Chemistry. 133:106425
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3365f298c2f053bcc4a1eb062aa3f036
https://doi.org/10.1016/j.bioorg.2023.106425
https://doi.org/10.1016/j.bioorg.2023.106425
Autor:
Shuai Wang, Jian-Tao Shi, Xing-Rong Wang, Hong-Xia Mu, Xue-Ting Wang, Kai-Yan Xu, Qing-Shan Wang, Shi-Wu Chen
Publikováno v:
Bioorganic Chemistry. 133:106412
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7948d1fd0e99275efba05d653960854a
https://doi.org/10.1016/j.bioorg.2023.106412
https://doi.org/10.1016/j.bioorg.2023.106412
Autor:
Shi-Wu Chen, Nan Ding, Rong-Hua Dou, Hai-Fang Jing, Xin-Yi Xie, Yan Xue, Yan Li, Wei-Dong Zhao, Guo-Hua Zhang, Gang Wang, Yong-Bo Hu, Yu-Kai Wang
Publikováno v:
Journal of Hypertension. 38:2270-2278
OBJECTIVES Cardiovascular dysautonomia can be present at early, late and even prodromal stages of Parkinson's disease. This study aimed to describe the characteristics of 24-h ambulatory blood pressure (BP) monitoring and investigate the frequency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95280386a7d1e6636aceffac8dd2599
https://doi.org/10.1097/hjh.0000000000002536
https://doi.org/10.1097/hjh.0000000000002536
Autor:
Xiao-Wei Chen, Jian-Wei Lv, Feng-Ming Qi, Fu-Min Zhang, Meng-En Chen, Xiao-Ming Zhang, Shi-Wu Chen, Shi-Zhong Tang, Hong-Li Bian
Publikováno v:
Organic Letters. 22:5314-5319
A general γ-C(sp2)-H iodination method directed by an aliphatic keto group has been developed under transition-metal-free conditions for the first time, generating iodoarenes in good to excellent yields with excellent site selectivity. This protocol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6632959488d100db3846a325ef8f5e3e
https://doi.org/10.1021/acs.orglett.0c01466
https://doi.org/10.1021/acs.orglett.0c01466
Autor:
Kai-Yan, Xu, Xue-Ting, Wang, Lei, Cheng, Qi-Hang, Cui, Jian-Tao, Shi, Li-Wen, Zhang, Shi-Wu, Chen
Publikováno v:
Bioorganic & Medicinal Chemistry. 78:117152
The bromodomain-containing protein 4 (BRD4) has gained growing interest as an effective drug target for the treatment of hepatocellular carcinoma (HCC). Herein, we designed and synthesized a series of quinoxalinone derivatives as BRD4 inhibitors via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d237e17a6d159fbed7d35bcf8e8c65cb
https://doi.org/10.1016/j.bmc.2022.117152
https://doi.org/10.1016/j.bmc.2022.117152