Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Shi-Qing Cai"'
Autor:
Shi-Qing Cai, Zhi-Mei Tang, Cen Xiong, Fei-Fei Wu, Jun-Ren Zhao, Qiang Zhang, Li Wang, Xiao-Nan Zhang, Xin-Huai Zhao
Publikováno v:
Current Research in Food Science, Vol 5, Iss , Pp 918-926 (2022)
The aims of the present study were to investigate the anti-inflammatory function of two flavonoids apigenin and genistein in rat intestinal epithelial (IEC-6) cells stimulated by tumor necrosis factor-alpha (TNF-α) and to clarify whether the heat tr
Externí odkaz:
https://doaj.org/article/aa439490152547609be043f863567274
Autor:
Qiang Jiang, Kai Li, Wen-Jing Lu, Shuang Li, Xin Chen, Xi-Juan Liu, Jie Yuan, Qiurong Ding, Feng Lan, Shi-Qing Cai
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Mutations in the voltage-gated K+ channel human ether-a-go-go-related gene (hERG) lead to Long-QT syndrome, causing life-threatening cardiac arrhythmia. Here the authors use C. elegans as a platform to run a channelopathy drug screen, identifying dru
Externí odkaz:
https://doaj.org/article/6fbe7f0d2c174c07a41338abdebd0bc4
Publikováno v:
Molecules, Vol 26, Iss 24, p 7495 (2021)
Flavonols possess several beneficial bioactivities in vitro and in vivo. In this study, two flavonols galangin and quercetin with or without heat treatment (100 °C for 15–30 min) were assessed for their anti-inflammatory activities in lipopolysacc
Externí odkaz:
https://doaj.org/article/c1a20c5658c6427b92cd30c5e48b33c9
Autor:
Menglong, Jin, Shi-Qing, Cai
Publikováno v:
Neuroscience Bulletin. 39:303-314
Aging is a major risk factor for many human diseases, including cognitive impairment, which affects a large population of the elderly. In the past few decades, our understanding of the molecular and cellular mechanisms underlying the changes associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd7d42ff3a715107cb1b9f4519ec20f
https://doi.org/10.1007/s12264-022-00969-9
https://doi.org/10.1007/s12264-022-00969-9
DNA topoisomerase 2-associated proteins PATL1 and PATL2 regulate the biogenesis of hERG K + channels
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The human ether-a-go-go-related gene (hERG) K + channel conducts a rapidly activating delayed rectifier K + current (I Kr ), which is essential for normal electrical activity of the heart. Precise regulation of hERG channel biogenesis is critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822c766ea0cc14495b22f4e02f4f2ff0
https://doi.org/10.1073/pnas.2206146120
https://doi.org/10.1073/pnas.2206146120
DNA topoisomerase 2-associated proteins PATL1 and PATL2 regulate the biogenesis of hERG K+ channels.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 1/10/2023, Vol. 120 Issue 2, p1-10, 18p
Autor:
Jie, Yuan, Shi-Qing, Cai
Publikováno v:
Yi chuan = Hereditas. 43(6)
With the increase of life expectancy, the world's population is aging rapidly. Previous work in the field of aging greatly increases our understanding of biological mechanisms underlying longevity. Researchers have unraveled a number of longevity pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5bf9451973adb77ad534b7e2c8c49a9
https://pubmed.ncbi.nlm.nih.gov/34284987
https://pubmed.ncbi.nlm.nih.gov/34284987
Autor:
Qiurong Ding, Xi-Juan Liu, Wen-Jing Lu, Feng Lan, Xin Chen, Qiang Jiang, Shuang Li, Shi-Qing Cai, Kai Li, Jie Yuan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Ion channels are important therapeutic targets, but the discovery of ion channel drugs remains challenging due to a lack of assays that allow high-throughput screening in the physiological context. Here we report C. elegans phenotype-based methods fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f055e29968b435399e2abf12f249bf98
http://link.springer.com/article/10.1038/s41467-018-06514-5
http://link.springer.com/article/10.1038/s41467-018-06514-5
Publikováno v:
The Journal of General Physiology
The mechanism underlying the biogenesis of hERG channels is not fully understood. Bai et al. identify CNX-1 as a novel regulator of ERG K+ channel biogenesis that is conserved from Caenorhabditis elegans to humans.
The human ether-a-go-go–rela
The human ether-a-go-go–rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1514f567024187c5dee88b3af14d4b0
http://europepmc.org/articles/PMC6080891
http://europepmc.org/articles/PMC6080891
Autor:
Kai Li, Haipeng Li, Zi-Qian Hao, Shi-Qing Cai, Xi-Juan Liu, Wen-Li Hu, Hong Li, Xin-Lei Kang, Jiang-An Yin, Yuan-Hong Shan, Ge Gao
Publikováno v:
Nature. 551:198-203
The rate of behavioural decline in the ageing population is remarkably variable among individuals. Despite the considerable interest in studying natural variation in ageing rate to identify factors that control healthy ageing, no such factor has yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d675c5f8fcc67d060a34c531aa9e37
https://doi.org/10.1038/nature24463
https://doi.org/10.1038/nature24463