Výsledky vyhledávání - "Shi-Liang Tseng"

Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a Novel Peripherally Restricted Cannabinoid-1 Receptor Antagonist with Significant Weight-Loss Efficacy in Diet-Induced Obese Mice

Autor: Ming-Shiu Hung, Kak-Shan Shia, Ming-Chen Chou, Kun-Hung Chen, Po-Chu Kuo, Chen-Tso Tseng, Ying-Chieh Wong, Pei-Hsuan Chen, Shi-Liang Tseng, Teng-Kuang Yeh, Ming-Hung Ou, Jen-Shin Song, Kuei-Hua Chang, Yu-Sheng Chao, Chien-Huang Wu, Yinchiu Lin, Amit A. Sadani, Chun-Ping Chang

Publikováno v: Journal of Medicinal Chemistry. 56:9920-9933

After extensive synthetic efforts, we found that many structurally diverse bioisosteres could be generated via derivatizing the C-4 alkyl chain on the pyrazole ring of compound 3 (B/P = 1/33) with different electronegative groups. Especially when a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ac61baf7245c5fa3bed4f850d15eaf
https://doi.org/10.1021/jm401158e

Zobrazit plný text záznamu

Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities

Autor: Wen-Chi Hsiao, Yu-Sheng Chao, Kak-Shan Shia, Chia-Yu Hsu, Wan-Ping Hsieh, Yinchiu Lin, Teng-Kuang Yeh, Ming-Shiu Hung, Shi-Liang Tseng

Publikováno v: Pharmacological Research. 62:337-343

A novel alkynylthiophene series of cannabinoid CB1 receptor antagonists has been described to exhibit distinct intrinsic activities with minimal substructure modifications. The three representatives, BPR0432, BPR0568 and BPR0569, functioning as a neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccdc85d61db6fa62d38b4ff01fc1d9e
https://doi.org/10.1016/j.phrs.2010.06.001

Zobrazit plný text záznamu

Discovery of 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an Active Metabolite. A Novel, Potent and Selective Cannabinoid-1 Receptor Inverse Agonist with High Antiobesity Efficacy in DIO Mice

Autor: Chien-Huang Wu, Ming-Shiu Hung, Chin-Yu Lin, Min-Tsang Hsieh, Jiing-Jyh Jan, Cheng-Ming Chu, Kak-Shan Shia, Ming-Chen Chou, Teng-Kuang Yeh, Horng-Shing Shy, Jen-Shin Song, Yu-Sheng Chao, Shi-Liang Tseng, Yen-Nan Yeh, Wan-Ping Hsieh, Yinchiu Lin, Chun-Wei Kuo, Wan-Ling Chung, Chun-Ping Chang

Publikováno v: Journal of Medicinal Chemistry. 52:4496-4510

By using the active metabolite 5 as an initial template, further structural modifications led to the identification of the titled compound 24 (BPR-890) as a highly potent CB1 inverse agonist possessing an excellent CB2/1 selectivity and remarkable in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac6e20afdcf3fb9a8eaeaa8d2478da8
https://doi.org/10.1021/jm900471u

Zobrazit plný text záznamu

Bioisosteric Replacement of the Pyrazole 5-Aryl Moiety of N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A Novel Series of Alkynylthiophenes as Potent and Selective Cannabinoid-1 Receptor Antagonists

Autor: Hua-Hao Chiu, Jen-Shin Song, Wan-Ping Hsieh, Ming-Shiu Hung, Cheng-Ming Chu, Kak-Shan Shia, Yen-Shih Tung, Chun-Ping Chang, Yu-Sheng Chao, Shi-Liang Tseng, Chien-Huang Wu, Yinchiu Lin, Wan-Ling Chung, Chia-Liang Tai, Chun-Wei Kuo

Publikováno v: Journal of Medicinal Chemistry. 51:5397-5412

Replacing the conventional pyrazole 5-aryl substituent of 1 (SR141716A) with the 2-thienyl moiety appended with an appropriate alkynyl unit, a novel class of 5-(5-alkynyl-2-thienyl)pyrazole derivatives, behaving as highly potent CB1 receptor antagoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b64e510b20574a19246cd45c653dbca
https://doi.org/10.1021/jm800066v

Zobrazit plný text záznamu

Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists

Autor: Chao Yu-Sheng, Min-Tsang Hsieh, Chia Chien Hsieh, Kak Shan Shia, Chun Wei Kuo, Hui Chuan Wu, Wan Ping Hsieh, Chia Liang Tai, Ming Shiu Hung, Jing Po Tsao, Jen Shin Song, Shi Liang Tseng, Vijay D. Pawar, Hua Hao Chiu

Publikováno v: Org. Biomol. Chem.. 6:447-450

A novel class of (5-(pent-1-enyl)thiophen-2-yl)pyrazole antagonists was discovered, many of which exhibited potent CB1 activity and good CB1/2 selectivity, suggesting that along with a 1,3-transposition of the carbonyl of the pyrazole 3-carboxamide,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9987dad5bd20a2eca00a967c3c825a42
https://doi.org/10.1039/b716434c

Zobrazit plný text záznamu

Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists

Autor: Shi-Liang, Tseng, Ming-Shiu, Hung, Chun-Ping, Chang, Jen-Shin, Song, Chia-Liang, Tai, Hua-Hao, Chiu, Wan-Ping, Hsieh, Yinchiu, Lin, Wan-Ling, Chung, Chun-Wei, Kuo, Chien-Huang, Wu, Cheng-Ming, Chu, Yen-Shih, Tung, Yu-Sheng, Chao, Kak-Shan, Shia

Publikováno v: Journal of medicinal chemistry. 51(17)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33b31c9727608011e806ce56cb11373f
https://pubmed.ncbi.nlm.nih.gov/18712856

Zobrazit plný text záznamu

The Application of Chiral Amino Thiols as Catalysts in the Enantioselective Addition of Diethylzinc to Aldehydes

Autor: Teng-Kuei Yang, Shi-Liang Tseng

Publikováno v: ChemInform. 36

Starting from ( S )-(−)-valine, a series of new chiral amino thiol and corresponding thioacetate ligands were prepared in an efficient manner and applied in the asymmetric diethylzinc addition to aldehydes with excellent enantioselectivity as high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1189c9d5c0fa37a983f66db1baa03692
https://doi.org/10.1002/chin.200512035

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání