Zobrazeno 1 - 5 of 5 pro vyhledávání: '"Shi-Han Wu"'
1
Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II
Autor: Qing-Xin Wang, Yu-Hao Cao, Li-Jin Yang, Yi-Yuan Ma, Nan Li, Shi-Han Wu, Lu Chen, Jia-Zhen Wu, Zhen-Jiang Tong, Xiao-Long Wang, Xin Xue, Ning Ding, Xue-Jiao Leng, Liang Chang, Wei-Chen Dai, Yan-Cheng Yu, Shan-Liang Sun, Ye Yang, Nian-Guang Li, Zhi-Hao Shi
Publikováno v: Future Medicinal Chemistry. 15:57-71
Aim: The clinical benefits of FLT3 inhibitors against acute myeloid leukemia (AML) have been limited by selectivity and resistance mutations. Thus, to identify FLT3 inhibitors possessing high selectivity and potency is of necessity. Methods & results
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4e2c6feedaad9225b8c2e4b4b234b20
https://doi.org/10.4155/fmc-2022-0231
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2
Scaffold-hopping of Linifanib to Design 6-Phenylisoxazolo[3,4-b]pyridin-3-amine Derivatives as FLT3 Inhibitors for Treating Acute Myeloid Leukemia
Autor: Zhi-Hao Shi, Nian-Guang Li, Shan-Liang Sun, Shi-Han Wu, Li-Jin Yang, Yi-Yuan Ma, Yu-Hao Cao, Zhen-Jiang Tong, Jia-Zhen Wu, Yi-Bo Wang, Jiu-Kai Sha, Ning Ding, Qiao-Li Liang, Liang Chang, Xiao-Long Wang, Jin-Ao Duan, Yan-Cheng Yu, Wei-Chen Dai, Ke Xie, Xue-Jiao Leng, Xin Xue
Publikováno v: Letters in Drug Design & Discovery. 20
Background: Acute myeloid leukemia (AML) is the most common type of blood cancer. Fms-like tyrosine kinase 3 (FLT3) is a member of the class III receptor tyrosine kinase family. Overexpression of FLT3 was found in 70-100% of patients with acute myelo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9250921b9447897024d7ae8b81f00588
https://doi.org/10.2174/1570180820666230519140242
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3
Medicinal Chemistry Strategies for the Development of Bruton’s Tyrosine Kinase Inhibitors against Resistance
Autor: Shan-Liang Sun, Shi-Han Wu, Ji-Bo Kang, Yi-Yuan Ma, Lu Chen, Peng Cao, Liang Chang, Ning Ding, Xin Xue, Nian-Guang Li, Zhi-Hao Shi
Publikováno v: Journal of Medicinal Chemistry. 65:7415-7437
Despite significant efficacy, one of the major limitations of small-molecule Bruton's tyrosine kinase (BTK) agents is the presence of clinically acquired resistance, which remains a major clinical challenge. This Perspective focuses on medicinal chem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ca716b6e50609f90af565ee8a6209b
https://doi.org/10.1021/acs.jmedchem.2c00030
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4
Synthesis and Biological Evaluation of 2-Amino-1-phenyl-benzimidazole Derivatives as BACE1 Inhibitors
Autor: Liang Chang, Qiao-Li Liang, Nian-Guang Li, Shan-Liang Sun, Xiao-Bin Dai, Shi-Han Wu, Ning Ding, Yi-Yuan Ma, Zhen-Jiang Tong, Jia-Zhen Wu, Yi-Bo Wang, Yan-Cheng Yu, Xue-Jiao Leng, Xin Xue, Jin-Guo Xu, Wei-Chen Dai, Ke Xie, Jing-Han Zhao, Yu-Qi Hong, Tian-Xi Lan, Tian-Yu Mu, Xiao-Long Wang
Publikováno v: Letters in Drug Design & Discovery. 20
Background: Alzheimer’s disease (AD), a chronic neurodegenerative disorder predominantly occurs among the elderly, is the leading cause of dementia. The accumulation of β-amyloid (Aβ) is considered the main pathogenies of AD, and β-site APP-clea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39196b9a437c00d50c0a0593f56125f8
https://doi.org/10.2174/1570180820666230223151850
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