Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Shi-Feng Chu"'
Autor:
Ye Peng, Jun-rui Ye, Sha-sha Wang, Wen-bin He, Zhong-ping Feng, Hong-shuo Sun, Shi-feng Chu, Zhao Zhang, Nai-hong Chen
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-17 (2023)
Abstract Parkinson’s disease (PD) is pathologically manifested by the aggregation of α-synuclein, which has been envisioned as a promising disease-modifying target for PD. Here, we identified 20C, a bibenzyl compound derived from Gastrodia elata,
Externí odkaz:
https://doaj.org/article/c502ea60b4eb41b9afd18262f3212636
Autor:
Xiao-xi Zheng, Cheng-feng Zhang, Li-qing Li, Jun-rui Ye, Si-yu Ren, Zhao Zhang, Xin He, Shi-feng Chu, Nai-hong Chen
Publikováno v:
Brain Research Bulletin, Vol 207, Iss , Pp 110871- (2024)
Context: Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, has been shown to exhibit anti-depressive effects in clinical trials. However, the direct mechanism underlying its effect on neuroinflammation remains unclear. Neuroinflammatory reac
Externí odkaz:
https://doaj.org/article/913df8c93b10420296425fb44d708d80
Autor:
Wen-yu Ma, Qing-lin Wu, Sha-sha Wang, Hong-yun Wang, Jun-rui Ye, Hong-shuo Sun, Zhong-ping Feng, Wen-bin He, Shi-feng Chu, Zhao Zhang, Nai-hong Chen
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-23 (2023)
Abstract Ischemic stroke is characterized by the presence of reactive microglia. However, its precise involvement in stroke etiology is still unknown. We used metabolic profiling and showed that chemokine like factor 1 (CKLF1) causes acute microglial
Externí odkaz:
https://doaj.org/article/7f8bc31b84224e17b6bcd65f5948714d
Autor:
Shi-feng Chu, Jun-tian Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 4, Iss 6, Pp 417-423 (2014)
Clausenamide (clau) is one of seven novel compounds isolated from Clausena lansium (Lour) skeels. Clau is unusual in that it contains 4 chiral centers yielding 8 pairs of enantiomers. After identification of the configuration of these enantiomers, th
Externí odkaz:
https://doaj.org/article/dc721b09937544ef84dbce10b9cef343
Publikováno v:
Molecules, Vol 23, Iss 11, p 2839 (2018)
Genetic studies have revealed that rare mutations and multiplications of the gene locus in α-synuclein (α-syn) are implicated in the pathogenesis of Parkinson’s disease (PD). However, the pathological effects of α-syn are still obscure. The neur
Externí odkaz:
https://doaj.org/article/19153a004f57497aa87dea5d7eb73446
Autor:
Yu-Zhu Wang, Ji Chen, Shi-Feng Chu, Yong-Sheng Wang, Xiao-Ying Wang, Nai-Hong Chen, Jun-Tian Zhang
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 4, Pp 504-510 (2009)
Ginsenoside Rg1 has been reported to improve cognitive function in many memory-impaired animal models. However, little is known about the bioactivity of its metabolites in the central nervous system in vivo. In the present study, we employed the step
Externí odkaz:
https://doaj.org/article/0d4ad88dc5954c35bae8928a77c015ed
Autor:
Cong-Yuan Xia, Ning-Ning Zhang, Hong Jiang, Yu-Xia Lou, Qian Ren, Xiao-Ling Zhang, Peng-Fei Yang, Qian-Hang Shao, Hao-Yu Zhu, Jiang-Fan Wan, Ya-Ni Zhang, Fang-Fang Li, Xu Yan, Shi-Feng Chu, Yi Zhang, Zhen-Zhen Wang, Nai-Hong Chen
Publikováno v:
Journal of Pharmacy and Pharmacology. 75:686-692
Objectives Fluoxetine has been used as the first line for the therapy of depression. However, lack of therapeutic efficacy and time lag still limit the application of fluoxetine. Gap junction dysfunction is a potentially novel pathogenic mechanism fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f08edd52e5f4e90f6f7a7491f794f85
https://doi.org/10.1093/jpp/rgad016
https://doi.org/10.1093/jpp/rgad016
Publikováno v:
Journal of Pharmacy and Pharmacology. 75:437-444
ObjectivesGinsenoside Rg1 (Rg1) has been well-documented to be effective against ischemic/reperfusion (I/R) injury. However, whether it has therapeutic effect on delayed neuronal death is still unclear. The aim of this study is to investigate the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::069138a04880ea173b2e4ce9963fff6c
https://doi.org/10.1093/jpp/rgac097
https://doi.org/10.1093/jpp/rgac097
Autor:
Qing-lin Wu, Li-yuan Cui, Wen-yu Ma, Sha-sha Wang, Zhao Zhang, Zhong-ping Feng, Hong-shuo Sun, Shi-feng Chu, Wen-bin He, Nai-hong Chen
Publikováno v:
Acta Pharmacologica Sinica.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::079d2acc7719ac0c403d245b866bf030
https://doi.org/10.1038/s41401-023-01100-y
https://doi.org/10.1038/s41401-023-01100-y
Publikováno v:
International immunopharmacology. 109
Microglia are the earliest activated and the longest lasting immune cells after stroke, and they participate in almost all the pathological reactions after stroke. However, their regulatory mechanism has not been fully elucidated. Triggering receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49730b79a56ca8b590c6456aca1db0aa
https://pubmed.ncbi.nlm.nih.gov/35525233
https://pubmed.ncbi.nlm.nih.gov/35525233