Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Shi-Chuen Miaw"'
Autor:
Chuan-Chuan Huang, Hsiang-Hsuan Sung, Hsiu-Chuan Li, Shi-Chuen Miaw, John T. Kung, Min-Yuan Chou, Betty A. Wu-Hsieh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Specific anti-CD3 treatment is deemed to be a promising therapy for allograft rejection and type 1 diabetes (T1D). Fc receptor (FcR) reduced-binding antibodies, by avoiding adverse effects of Fc and FcR interaction, have good therapeutic potential. W
Externí odkaz:
https://doaj.org/article/e3da1c5589e2465696578dcf32b35bad
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Macrophages comprise the front line of defense against various pathogens. Classically activated macrophages (M1), induced by IFN-γ and LPS, highly express inflammatory cytokines and contribute to inflammatory processes. By contrast, alternatively ac
Externí odkaz:
https://doaj.org/article/b5491e21c5154253bd553f365c05c89d
Autor:
Ting-Fang Chou, Ya-Ting Chuang, Wan-Chen Hsieh, Pei-Yun Chang, Hsin-Yu Liu, Shu-Ting Mo, Tzu-Sheng Hsu, Shi-Chuen Miaw, Ruey-Hwa Chen, Adi Kimchi, Ming-Zong Lai
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regu
Externí odkaz:
https://doaj.org/article/760f4386456742798a6a43da19805d86
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
c-Maf belongs to the large Maf family of transcription factors and plays a key role in the regulation of cytokine production and differentiation of TH2, TH17, TFH, and Tr1 cells. Invariant natural killer T (iNKT) cells can rapidly produce large quant
Externí odkaz:
https://doaj.org/article/8a1bfea1037c4e6d9712773302ab7a16
Autor:
Chih-Chun Liu, Chen-Yen Lai, Wei-Feng Yen, Yu-Hsien Lin, Hui-Hsin Chang, Tzong-Shyuan Tai, Yu-Jung Lu, Hsiao-Wei Tsao, I-Cheng Ho, Shi-Chuen Miaw
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127617 (2015)
C-Maf plays an important role in regulating cytokine production in TH cells. Its transactivation of IL-4 is optimized by phosphorylation at Tyr21, Tyr92, and Tyr131. However, the molecular mechanism regulating its tyrosine phosphorylation remains unk
Externí odkaz:
https://doaj.org/article/80541e89c3f6443cb51bc2106e215827
Autor:
Hui-Hsin Chang, Tzong-Shyuan Tai, Bing Lu, Christine Iannaccone, Manuela Cernadas, Michael Weinblatt, Nancy Shadick, Shi-Chuen Miaw, I-Cheng Ho
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33067 (2012)
PTPN22 is a tyrosine phosphatase and functions as a damper of TCR signals. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) confers the highest risk of
Externí odkaz:
https://doaj.org/article/4c6cf122014844ae9f50b5bcc7ffb615
Autor:
Po-Hao Hsu, Shi-Chuen Miaw, Chau-Ching Chuang, Pei-Yu Chang, Ssu-Ju Fu, Guey-Mei Jow, Mei-Miao Chiu, Chung-Jiuan Jeng
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41203 (2012)
The ether-à-go-go (Eag) potassium (K(+)) channel belongs to the superfamily of voltage-gated K(+) channel. In mammals, the expression of Eag channels is neuron-specific but their neurophysiological role remains obscure. We have applied the yeast two
Externí odkaz:
https://doaj.org/article/436bfd8f9e334778ab5f10111fae7c57
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Autophagy is found to serve as a surviving mechanism for cancer cells. Inhibiting autophagy has been considered as an adjuvant anti-cancer strategy. In this study, we investigated the anti-tumor effect of combining pulsed-wave ultrasound hyperthermia
Autor:
Li Ling Wu, Hurng-Yi Wang, Yan Rong Chen, Yen Tien Hong, Hui Lin Wu, Shi-Chuen Miaw, Pei Hsuan Liao, Shiou-Hwei Yeh, Jing Shan Lin, Pei-Jer Chen, Hung-Chih Yang, Ding-Shinn Chen, Wei Hao Peng
Publikováno v:
Hepatology. 69:2364-2380
To understand the mechanism(s) of age-dependent outcomes of hepatitis B virus (HBV) infection in humans, we previously established an age-related HBV mouse model in which 6-week-old (N6W) C3H/HeN mice exhibited virus tolerance whereas 12-week-old (N1
Autor:
Shi-Chuen Miaw, Yu-Hone Hsu, Yan-Zhang Lee, Win-Li Lin, Chih-Chun Liu, Ting-Chuan Li, Chi-Feng Chiang
Publikováno v:
International journal of radiation oncology, biology, physics. 108(1)
Purpose In this study, we hypothesized that systemic antitumor immunity might be enhanced by combining pulsed-wave ultrasound hyperthermia (pUSHT) with OK-432 and that the induced antitumor immunity could confer protection against tumorigenesis. Thes