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Autor:
Shi-Chu Ng ng, Xiaohong Song, Milan Bruncko, Cheol-Min Park, Steven W. Elmore, Stephen W. Fesik, Kunzer Aaron R, Wendt Michael D, Saul H. Rosenberg, Mcclellan William J, Barbara A. Belli, Wang Xilu, Thorsten Oost, Andrew M. Petros, Darlene Martineau, Alexander R. Shoemaker, Haichao Zhang, Mary K. Joseph, Michael J. Mitten, Paul Nimmer, Tilman Oltersdorf, Hong Ding
Publikováno v:
Journal of medicinal chemistry. 50(4)
Overexpression of the antiapototic proteins Bcl-2 and Bcl-xL provides a common mechanism through which cancer cells gain a survival advantage and become resistant to conventional chemotherapy. Inhibition of these prosurvival proteins is an attractive