Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Shi Shan Mao"'
1
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection
Autor: Ting-Jen R. Cheng, Jiun-Jie Shie, Jia Tsrong Jan, Ting Hung Chou, Wen-Bin Yang, Wei-Chieh Cheng, Chi-Huey Wong, Shang-Cheng Hung, Rong-Jie Chein, Hsiu Hua Ma, Cheng Wei Cheng, Pi-Hui Liang, Xiaorui Chen, Ying-Ta Wu, Che Ma, Yu Pu Juang, Shi Shan Mao
Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 118(5):e20211579118
Significance COVID-19 is a global pandemic currently lacking an effective cure. We used a cell-based infection assay to screen more than 3,000 agents used in humans and animals and identified 15 with antiinfective activity, ranging from 0.1 nM to 50
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006ff36b872509529e809eb42882f41c
https://doi.org/10.1073/pnas.2021579118
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3
Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
Autor: Nicole Trainor, Christine Fandozzi, Kevin F. Gilbert, Joseph J. Romano, Bang-Lin Wan, Shi-Shan Mao, John Swestock, John A. McCauley, M. Katharine Holloway, David B. Olsen, Nigel J. Liverton, Kimberly J. Bush, Donald J. Graham, Mark Stahlhut, Steven S. Carroll, John W. Butcher, Steven W. Ludmerer, Michael T. Rudd, Jillian DiMuzio, Kevin Nguyen, Joseph P. Vacca, Charles J. Mcintyre
Publikováno v: Journal of Medicinal Chemistry. 53:2443-2463
A new class of HCV NS3/4a protease inhibitors which contain a P2 to P4 macrocyclic constraint was designed using a molecular-modeling derived strategy. Exploration of the P2 heterocyclic region, the P2 to P4 linker, and the P1 side chain of this clas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca278167f94eed395382711e9a327f60
https://doi.org/10.1021/jm9015526
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4
A time-resolved, internally quenched fluorescence assay to characterize inhibition of hepatitis C virus nonstructural protein 3–4A protease at low enzyme concentrations
Autor: Jillian DiMuzio, Carolyn McHale, David B. Olsen, Christine Burlein, Steven S. Carroll, Shi-Shan Mao
Publikováno v: Analytical Biochemistry. 373:1-8
The hepatitis C virus (HCV) nonstructural protein 3 (NS3) with its cofactor NS4A is a pivotal enzyme for the replication of HCV. Inhibition of NS3-4A protease activity has been validated as an antiviral target in clinical studies of inhibitors of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8864ec40187edbe35a70972291658a3b
https://doi.org/10.1016/j.ab.2007.10.041
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5
Demonstration of enhanced endogenous fibrinolysis in thrombin activatable fibrinolysis inhibitor-deficient mice
Autor: Guoxin Wu, Shi-Shan Mao, Steven S. Carroll, Dennis Colussi, Marie A. Holahan, Carolyn Bailey, Jacquelynn J. Cook
Publikováno v: Blood Coagulation & Fibrinolysis. 16:407-415
To investigate the importance of thrombin activatable fibrinolysis inhibitor (TAFI) in the stabilization of plasma clots, we have compared fibrinolysis in TAFI-deficient (KO) and wild-type (WT) littermate mice. TAFI-deficient mice were previously gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48f78587b08e65fc056f07e5a264f63
https://doi.org/10.1097/01.mbc.0000181175.62437.2a
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6
Miniaturizable homogenous time-resolved fluorescence assay for carboxypeptidase B activity
Autor: Berta Strulovici, Shi-Shan Mao, Marc Ferrer, Carolyn Bailey, Richard Peltier, Stephen J. Gardell, Paul Zuck, Garrett D. Kolodin, James Inglese
Publikováno v: Analytical Biochemistry. 317:94-98
An epitope-unmasking, homogeneous time-resolved fluorescence (HTRF) assay has been developed for measuring carboxypeptidase B (CPB) activity in a miniaturized high-throughput screening format. The enzyme substrate (biotin-RYRGLMVGGVVR- oh ) is cleave
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f5ceb52112855acbecddae9f31ee7b
https://doi.org/10.1016/s0003-2697(03)00048-4
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7
Characterization of Plasmin-mediated Activation of Plasma Procarboxypeptidase B
Autor: Stephen J. Gardell, Shi-Shan Mao, C. M. Cooper, Theresa Wood, Jules A. Shafer
Publikováno v: Journal of Biological Chemistry. 274:35046-35052
Plasma carboxypeptidase B (PCB) is an exopeptidase that exerts an antifibrinolytic effect by releasing C-terminal Lys and Arg residues from partially degraded fibrin. PCB is produced in plasma via limited proteolysis of the zymogen, pro-PCB. In this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::026f244e423e3b134900b20b6b23b905
https://doi.org/10.1074/jbc.274.49.35046
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8
Expression and Purification of Recombinant Tick Anticoagulant Peptide (Y1W/D10R) Double Mutant Secreted bySaccharomyces cerevisiae
Autor: Loren D. Schultz, Shi-Shan Mao, Charlotte C Ip, Jin Huang, Hugh A. George, Mohinder K. Sardana, Joseph G. Joyce, E. Dale Lehman, James C. Cook, William J. Miller, Henry Z. Markus, Wayne K. Herber
Publikováno v: Protein Expression and Purification. 13:291-300
A double mutant of tick anticoagulant peptide (TAP) was cloned as a chimeric fusion with the yeast α-mating factor pre-proleader peptide. Expression in yeast ( Saccharomyces cerevisiae ) resulted in the secretion of the TAP mutein into the culture m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132228cbebb0f6bb5267a0c67d7ac187
https://doi.org/10.1006/prep.1998.0893
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9
Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position
Autor: Shi-Shan Mao, E P Baskin, Julie A. Krueger, Mark G. Bock, Dong-Mei Feng, A. M. Mulichak, Stephen J. Gardell, Roger M. Freidinger, Lucas R, Ramjit Hg, Jules A. Shafer, S. D. Lewis, R Woltmann, K B Dancheck, Timothy R. Hare, J.J. Lynch, Adel M. Naylor-Olsen, I.-W. Chen, Zhongguo Chen, Joe P. Vacca
Publikováno v: Journal of Medicinal Chemistry. 40:3726-3733
A novel class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position has been discovered. Four of these thrombin inhibitors (13b,c,e and 14d) showed nanomolar potency (Ki 0.8-12 nM), 300-1500-fold selectivity for thrombin compa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a9c3eb4d8f15436d50d759edace5a6
https://doi.org/10.1021/jm970493r
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10
Identification and Characterization of Variants of Tick Anticoagulant Peptide with Increased Inhibitory Potency toward Human Factor Xa
Autor: Shi-Shan Mao, Jules A. Shafer, Neeper Michael P, Jin Huang, Victor M. Garsky, Carolee Welebob
Publikováno v: Biochemistry. 34:5098-5103
Tick anticoagulant peptide (TAP) is a specific and potent inhibitor of factor Xa (fXa), a central enzyme in the blood clotting cascade. As such, TAP is a potential antithrombotic agent. Site-directed mutagenesis studies were undertaken to determine t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff7341926b440d1c37db482330e36f7
https://doi.org/10.1021/bi00015a021
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