Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Shi Jie Tay"'
Autor:
Ryan Haryadi, Kah Fai Chan, Pao Chun Lin, Yun Lei Tan, Corrine Wan, Wahyu Shahreel, Shi Jie Tay, Terry Nguyen-Khuong, Ian Walsh, Zhiwei Song
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract This report describes the development and characterization of a comprehensive collection of CHO cell glycosylation mutants with significant potential for advancing glycobiology and biotechnology. EPO-Fc and trastuzumab, two model molecules,
Externí odkaz:
https://doaj.org/article/75542e73d23a4b45832f4c42a7c4b5fe
Autor:
Ngan T. B. Nguyen, Hau Wan Leung, Kuin Tian Pang, Shi Jie Tay, Ian Walsh, Andre B. H. Choo, Yuansheng Yang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Monoclonal antibodies (mAbs) eliminate cancer cells via various effector mechanisms including antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which are influenced by the N-glycan structures o
Externí odkaz:
https://doaj.org/article/ee625f6c9b794d9b9acf5a57efcd681b
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114757- (2023)
The circulatory half-life of recombinant therapeutic proteins is an important pharmacokinetic attribute because it determines the dosing frequency of these drugs, translating directly to treatment cost. Thus, recombinant therapeutic glycoproteins suc
Externí odkaz:
https://doaj.org/article/a560f677b3cf4a09bd98741e1d085795
Autor:
Ngan T. B. Nguyen, Jianer Lin, Shi Jie Tay, Mariati, Jessna Yeo, Terry Nguyen-Khuong, Yuansheng Yang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Therapeutic antibodies are decorated with complex-type N-glycans that significantly affect their biodistribution and bioactivity. The N-glycan structures on antibodies are incompletely processed in wild-type CHO cells due to their limited gl
Externí odkaz:
https://doaj.org/article/d6016d0862bc4687baedcd7b078f5685
Autor:
Ian Walsh, Matthew S. F. Choo, Sim Lyn Chiin, Amelia Mak, Shi Jie Tay, Pauline M. Rudd, Yang Yuansheng, Andre Choo, Ho Ying Swan, Terry Nguyen-Khuong
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2087-2099 (2020)
The accurate assessment of antibody glycosylation during bioprocessing requires the high-throughput generation of large amounts of glycomics data. This allows bioprocess engineers to identify critical process parameters that control the glycosylation
Externí odkaz:
https://doaj.org/article/3a87638c992641a195d5dc6c94c19a48
Autor:
Sean Chia, Gavin Teo, Shi Jie Tay, Larry Sai Weng Loo, Corrine Wan, Lyn Chiin Sim, Hanry Yu, Ian Walsh, Kuin Tian Pang
Publikováno v:
Foods, Vol 11, Iss 13, p 1952 (2022)
It is estimated that food fraud, where meat from different species is deceitfully labelled or contaminated, has cost the global food industry around USD 6.2 to USD 40 billion annually. To overcome this problem, novel and robust quantitative methods a
Externí odkaz:
https://doaj.org/article/b968a834d2da49eab9f08763ca04e40e
Autor:
Kuin Tian Pang, Shi Jie Tay, Corrine Wan, Ian Walsh, Matthew S. F. Choo, Yuan Sheng Yang, Andre Choo, Ying Swan Ho, Terry Nguyen-Khuong
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The glycosylation of antibody-based proteins is vital in translating the right therapeutic outcomes of the patient. Despite this, significant infrastructure is required to analyse biologic glycosylation in various unit operations from biologic develo
Externí odkaz:
https://doaj.org/article/c204a7231e9743bab646ee89409bb6d4
Autor:
Yuansheng Yang, Pauline M. Rudd, Sabine L. Flitsch, jien nee tai, Terry Nguyen-Khuong, Shi Jie Tay, Say Kong Ng, Ian Walsh, Matthew S F Choo, Edward Pallister
Publikováno v:
Analytical Chemistry. 92:15323-15335
High-throughput glycan analysis has become an important part of biopharmaceutical production and quality control. However, it is still a significant challenge in the field of glycomics to easily deduce isomeric glycan structures, especially in a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c826a6f135b3a9e6dc5c3df84a0a9712
https://doi.org/10.1021/acs.analchem.0c01954
https://doi.org/10.1021/acs.analchem.0c01954
Autor:
Shi Jie Tay, Ian Walsh, Andre Choo, Sim Lyn Chiin, Matthew S F Choo, Terry Nguyen-Khuong, Amelia Mak, Pauline M. Rudd, Yang Yuansheng, Ho Ying Swan
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2087-2099 (2020)
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2087-2099 (2020)
The accurate assessment of antibody glycosylation during bioprocessing requires the high-throughput generation of large amounts of glycomics data. This allows bioprocess engineers to identify critical process parameters that control the glycosylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b805f8c478d676e5ef403d96005bb4
http://europepmc.org/articles/PMC7476600
http://europepmc.org/articles/PMC7476600
Autor:
Shi Jie Tay, Matthew S F Choo, Christopher H. Taron, Katherine Wongtrakul-Kish, Pauline M. Rudd, Sophie Zhao, Terry Nguyen-Khuong, Ian Walsh
Publikováno v:
Glycosylation ISBN: 9781071616840
Glycosylation is important in biology, contributing to both protein conformation and function. Structurally, glycosylation is complex and diverse. This complexity is reflected in the topology, composition, monosaccharide linkages, and isomerism of ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::693b30f6c7bf262a7cfac476627a87d4
https://doi.org/10.1007/978-1-0716-1685-7_1
https://doi.org/10.1007/978-1-0716-1685-7_1
