Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shi Hua D. Heath"'
Publikováno v:
Mechanisms of Ageing and Development. 133:99-106
The aging heart displays a loss of bioenergetic reserve capacity partially mediated through lower fatty acid utilization. We investigated whether the age-related impairment of cardiac fatty acid catabolism occurs, at least partially, through diminish
Publikováno v:
Free Radical Biology and Medicine. 35:1064-1072
Cardiac mitochondria are composed of two distinct subpopulations: one beneath the sarcolemma (subsarcolemmal mitochondria: SSM), and another along the myofilaments (interfibrillary mitochondria: IFM). Previous studies suggest a preferential loss of I
Publikováno v:
Antioxidants & Redox Signaling. 5:517-527
4-hydroxynonenal (HNE), a product of omega-6 polyunsaturated fatty acid peroxidation, impairs mitochondrial respiration in vitro by adducting the alpha-ketoglutarate dehydrogenase complex (KGDC) and inhibiting its activity. The present study seeks to
Publikováno v:
Antioxidantsredox signaling. 10(5)
Glutathione (GSH) and glutathione disulfide (GSSG) form the principal thiol redox couple in the endoplasmic reticulum (ER); however, few studies have attempted to quantify GSH redox status in this organelle. To address this gap, GSH and GSSG levels a
Publikováno v:
Biochemical and biophysical research communications. 325(1)
Mitochondrial uptake and beta-oxidation of long-chain fatty acids are markedly impaired in the aging rat heart. While these alterations would be expected to adversely affect overall pyridine nucleotides, NADH levels do not change significantly with a
Publikováno v:
Antioxidants & Redox Signaling; May2008, Vol. 10 Issue 5, p963-972, 10p
Publikováno v:
Antioxidants & Redox Signaling; 10/01/2003, Vol. 5 Issue 5, p517-527, 11p