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Akademický článek

PXDN as a pan-cancer biomarker and promotes tumor progress via immune inhibition in nasopharyngeal carcinoma

Autor: Yu-Chun Li, Yan-Hong Xiao, Fei-Xiong Chen, Si-Yu Xiao, Jian-Mei Lin, Shu-Tao Cai, Cui-Lan Zeng, Xue-Yan Ye, Xu-Fa Yu, Li Yuan, Shi-Bing Li

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundInvestigating oncogenes and the mechanisms driving oncogenic processes in human tumors is imperative for the development of efficient therapies. Peroxidasin (PXDN) has been reported to play a critical role in tissue development and homeosta

Externí odkaz: https://doaj.org/article/6f0c78d81dd4446c9a40ff93778645f4

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Akademický článek

Staged transverse preputial island flap urethroplasty for some proximal hypospadias with moderate-to-severe chordee

Autor: Hai Lin, Yu-Yun Wang, Shi-Bing Li, Ze-Ting Chen, Liang-Ju Su

Publikováno v: BMC Urology, Vol 21, Iss 1, Pp 1-7 (2021)

Abstract Background We aimed to assess the outcome of staged transverse preputial island flap (TPIF) urethroplasty for repairing certain cases of primary proximal hypospadias with moderate-to-severe chordee in children. Methods Nighty-two consecutive

Externí odkaz: https://doaj.org/article/5ba57d73d534480f9b0d3a77981ecae4

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Akademický článek

Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 9, Pp 1-19 (2020)

Abstract Metabolic reprogramming plays important roles in development and progression of nasopharyngeal carcinoma (NPC), but the underlying mechanism has not been completely defined. In this work, we found INSL5 was elevated in NPC tumor tissue and t

Externí odkaz: https://doaj.org/article/621a29cd73654baba154f0c200991840

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Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
EMBO Molecular Medicine

Metabolic reprogramming plays important roles in development and progression of nasopharyngeal carcinoma (NPC), but the underlying mechanism has not been completely defined. In this work, we found INSL5 was elevated in NPC tumor tissue and the plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2211831553753a31c09307e8987413c4
https://doaj.org/article/621a29cd73654baba154f0c200991840

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EphA2 phosphorylates NLRP 3 and inhibits inflammasomes in airway epithelial cells

Autor: Yong Du, Junji Xing, Zhiqiang Zhang, Hua Zhang, Mingli Fang, Tian-Liang Xia, Ao Zhang, Mu Sheng Zeng, Shi-Bing Li, Xian Chang Li

Publikováno v: EMBO Rep

Inflammasomes are intracellular complexes that form in the cytosol of inflammatory cells. NLRP3 is one of the sensor proteins in the complex that can recognize a wide variety of stimuli ranging from microbial components to environmental particulates.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5fa33a58efda5d7ad4f3b3099c1604
https://doi.org/10.15252/embr.201949666

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Identification of a sodium pump Na + /K + ATPase α1-targeted peptide for PET imaging of breast cancer

Publikováno v: Journal of Controlled Release. 281:178-188

The sodium pump Na+/K+ ATPase a1 subunit(NKA a1), an attractive cancer-related biomarker and therapeutic target, is closely related to the development and progression of several cancers including breast cancer. Currently, a NKA a1 inhibitor, UNBS1450

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::343639b9becb6aaf3db3be6210676282
https://doi.org/10.1016/j.jconrel.2018.05.019

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Plasma Macrophage Migration Inhibitory Factor and CCL3 as Potential Biomarkers for Distinguishing Patients with Nasopharyngeal Carcinoma from High-Risk Individuals Who Have Positive Epstein-Barr Virus Capsid Antigen-Specific IgA

Autor: Min Jie Mao, Xueping Wang, Dan Liu, Qian Zhong, Shan Xing, Jian Hua Lin, Mu Sheng Zeng, Shi Bing Li, Ning Xue, Yan Zhen Lai, Wan Li Liu

Publikováno v: Cancer Research and Treatment : Official Journal of Korean Cancer Association

Purpose The purpose of this study was to identify novel plasma biomarkers for distinguishing nasopharyngeal carcinoma (NPC) patients from healthy individuals who have positive Epstein-Barr virus (EBV) viral capsid antigen (VCA-IgA). Materials and met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6841ad52149eea49222604e8374d109d
http://europepmc.org/articles/PMC6333976

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Ephrin receptor A2 is an epithelial cell receptor for Epstein–Barr virus entry

Publikováno v: Nature Microbiology. 3:1-8

Epstein-Barr virus (EBV) is causally associated with nasopharyngeal carcinoma, 10% of gastric carcinoma and various B cell lymphomas 1 . EBV infects both B cells and epithelial cells 2 . Recently, we reported that epidermal growth factor and Neuropil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ab9fe44db767be3508012ecc1f1540
https://doi.org/10.1038/s41564-017-0080-8

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Elevated expression of CST1 promotes breast cancer progression and predicts a poor prognosis

Autor: Tian Liang Xia, Mu Sheng Zeng, Yong Du, Shi xun Lu, Ning Xue, Zhi ping Zhao, Bo Chen, Da nian Dai, Ai Jun Zhou, Shi Bing Li, Qian Zhong, Yan Li, Wei dong Wei

Publikováno v: Journal of Molecular Medicine (Berlin, Germany)

Abstract Cystatin SN (CST1) belongs to the type 2 cystatin (CST) superfamily, which restricts the proteolytic activities of cysteine proteases. CST1 has been recently considered to be involved in the development of several human cancers. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598713a82d5e87fa3cdbeb56722f8877
https://doi.org/10.1007/s00109-017-1537-1

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