Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Shi‐Mei Zhuang"'
Autor:
Zhan-Li Chen, Chen Xie, Wei Zeng, Rui-Qi Huang, Jin-E Yang, Jin-Yu Liu, Ya-Jing Chen, Shi-Mei Zhuang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasome-mediated protein degradation i
Externí odkaz:
https://doaj.org/article/2f9e3c29bdb949618c0f3d211b851226
Autor:
Jin‐E Yang, Wang‐Jing Zhong, Jin‐Feng Li, Ying‐Ying Lin, Feng‐Ting Liu, Hao Tian, Ya‐Jing Chen, Xiao‐Yu Luo, Shi‐Mei Zhuang
Publikováno v:
Molecular Oncology, Vol 17, Iss 5, Pp 901-916 (2023)
The biological functions of short open reading frame (sORF)‐encoded micropeptides remain largely unknown. Here, we report that LINC00998, a previously annotated lncRNA, was upregulated in multiple cancer types and the sORF on LINC00998 encoded a mi
Externí odkaz:
https://doaj.org/article/b9d2b14013b34f4c8dd53497ee48dc0c
Autor:
Meng-Zhi Wu, Yi-chuan Yuan, Bi-Yu Huang, Jin-Xi Chen, Bin-Kui Li, Jian-Hong Fang, Shi-Mei Zhuang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract Aberrant activation of the TGF-β/SMAD signaling pathway is often observed in hepatocellular carcinoma (HCC). Whether lncRNA regulates the TGF-β/SMAD signaling remains largely unknown. Here, we identified an oncogenic lncRNA that was upregu
Externí odkaz:
https://doaj.org/article/fbe62e45283a4e7e874c2f402866d1ea
Autor:
Jin-Yu Liu, Ya-Jing Chen, Huan-Hui Feng, Zhan-Li Chen, Yun-Long Wang, Jin-E Yang, Shi-Mei Zhuang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Abstract Oncogenic c-Myc is a master regulator of G1/S transition. Long non-coding RNAs (lncRNAs) emerge as new regulators of various cell activities. Here, we found that lncRNA SnoRNA Host Gene 17 (SNHG17) was elevated at the early G1-phase of cell
Externí odkaz:
https://doaj.org/article/8dccee052e4242eb853ebc8d2d9d499e
Autor:
Wan-Ru Ning, Da Jiang, Xing-Chen Liu, Yu-Fan Huang, Zhi-Peng Peng, Ze-Zhou Jiang, Tiebang Kang, Shi-Mei Zhuang, Yan Wu, Limin Zheng
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)
Macrophages constitute a major immune component in tumor tissues, but how these cells adapt to and survive in the nutrient-depleted and lactic acid–induced acidic tumor microenvironments is not yet fully understood. Here, we found that levels of ca
Externí odkaz:
https://doaj.org/article/edd49213ea67455ca410bc1e39316261
Publikováno v:
Advanced Science, Vol 8, Iss 7, Pp n/a-n/a (2021)
Abstract Many long noncoding RNAs (lncRNAs) have been annotated, but their functions remain unknown. The authors found a novel lnc‐APUE (lncRNA accelerating proliferation by upregulating E2F1) that is upregulated in different cancer types, includin
Externí odkaz:
https://doaj.org/article/6265769f9678427db3c3d44b3c600191
Publikováno v:
Advanced Science, Vol 7, Iss 21, Pp n/a-n/a (2020)
Abstract Acetylation is a critical mechanism to modulate tumor‐suppressive activity of p53, but the causative roles of long non‐coding RNAs (lncRNAs) in p53 acetylation and their biological significance remain unexplored. Here, lncRNA LOC10029414
Externí odkaz:
https://doaj.org/article/2a7d094d8d6341c29dd5fd0330a8345c
Autor:
Liang Yang, Haite Tang, Xiaobing Lin, Yi Wu, Sheng Zeng, Yongzhang Pan, Yukun Li, Ge Xiang, Yi-Fang Lin, Shi-Mei Zhuang, Zhiyin Song, Yiguo Jiang, Xingguo Liu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Optic Atrophy 1 (OPA1) has well-established roles in both mitochondrial fusion and apoptotic crista remodeling and is required for the maintenance and distribution of mitochondrial DNA (mtDNA), which are essential for energy metabolism. However, the
Externí odkaz:
https://doaj.org/article/0d7372cd69674f4eba43e0a7c2063873
Autor:
Kai You, Song-Yang Li, Jiao Gong, Jian-Hong Fang, Chong Zhang, Min Zhang, Yunfei Yuan, Jine Yang, Shi-Mei Zhuang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 57-66 (2018)
miR-125b is frequently dysregulated in different diseases. Activation of hepatic stellate cells (HSCs) is a critical event during liver fibrogenesis. However, the function and its underlying mechanism of miR-125b in HSC activation and liver fibrosis
Externí odkaz:
https://doaj.org/article/cff15bebac664b7b82ccfae7691a6b86
Autor:
Xue-Jia Lin, Jian-Hong Fang, Xiao-Jing Yang, Chong Zhang, Yunfei Yuan, Limin Zheng, Shi-Mei Zhuang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 243-252 (2018)
We previously found that 19 microRNAs (miRNAs) significantly increased in the sera of hepatocellular carcinoma (HCC) patients. Here, we evaluated whether these miRNAs were secreted by HCC cells and contributed to tumor angiogenesis. High level of miR
Externí odkaz:
https://doaj.org/article/da249cf2db734236adf40976562b77b0