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Ultraconserved enhancer function does not require perfect sequence conservation

Autor: Snetkova, Valentina, Ypsilanti, Athena R, Akiyama, Jennifer A, Mannion, Brandon J, Plajzer-Frick, Ingrid, Novak, Catherine S, Harrington, Anne N, Pham, Quan T, Kato, Momoe, Zhu, Yiwen, Godoy, Janeth, Meky, Eman, Hunter, Riana D, Shi, Marie, Kvon, Evgeny Z, Afzal, Veena, Tran, Stella, Rubenstein, John LR, Visel, Axel, Pennacchio, Len A, Dickel, Diane E

Publikováno v: Nature genetics, vol 53, iss 4

Ultraconserved enhancer sequences show perfect conservation between human and rodent genomes, suggesting that their functions are highly sensitive to mutation. However, current models of enhancer function do not sufficiently explain this extreme evol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::885ae55c51d0204911f377a1160700a7
https://pubmed.ncbi.nlm.nih.gov/33782604

Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold.

Autor: Ghosh U, Tse E, Yang H, Shi M, Carlo CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 28. Date of Electronic Publication: 2024 May 28.

ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function.

Autor: Galang G; Cardiology Division (G.G., R.M., H.R., C.J., R.S.W., P.K.R.A., A.R., M.B.S., V.V.), University of California, San Francisco., Mandla R; Cardiology Division (G.G., R.M., H.R., C.J., R.S.W., P.K.R.A., A.R., M.B.S., V.V.), University of California, San Francisco., Ruan H; Cardiology Division (G.G., R.M., H.R., C.J., R.S.W., P.K.R.A., A.R., M.B.S., V.V.), University of California, San Francisco., Jung C; Cardiology Division (G.G., R.M., H.R., C.J., R.S.W., P.K.R.A., A.R., M.B.S., V.V.), University of California, San Francisco., Sinha T; Cardiovascular Research Institute (T.S., R.S.W., B.L.B., V.V.), University of California, San Francisco., Stone NR; Gladstone Institute of Cardiovascular Disease, San Francisco, CA (N.R.S.)., Wu RS; Cardiology Division (G.G., R.M., H.R., C.J., R.S.W., P.K.R.A., A.R., M.B.S., V.V.), University of California, San Francisco.; Cardiovascular Research Institute (T.S., R.S.W., B.L.B., V.V.), University of California, San Francisco., Mannion BJ; Environmental and Systems Biology Division, Lawrence Berkeley National Laboratory, CA (B.J.M., L.A.P.).; Department of Energy Joint Genome Institute, Berkeley, CA (B.J.M., L.A.P.).; Comparative Biochemistry Program, University of California, Berkeley (B.J.M., L.A.P.)., Allu PKR; Cardiology Division (G.G., R.M., H.R., C.J., R.S.W., P.K.R.A., A.R., M.B.S., V.V.), University of California, San Francisco., Chang K; School of Medicine (K.C.), University of California, San Francisco., Rammohan A; Cardiology Division (G.G., R.M., H.R., C.J., R.S.W., P.K.R.A., A.R., M.B.S., V.V.), University of California, San Francisco., Shi MB; Cardiology Division (G.G., R.M., H.R., C.J., R.S.W., P.K.R.A., A.R., M.B.S., V.V.), University of California, San Francisco., Pennacchio LA; Environmental and Systems Biology Division, Lawrence Berkeley National Laboratory, CA (B.J.M., L.A.P.).; Department of Energy Joint Genome Institute, Berkeley, CA (B.J.M., L.A.P.).; Comparative Biochemistry Program, University of California, Berkeley (B.J.M., L.A.P.)., Black BL; Cardiovascular Research Institute (T.S., R.S.W., B.L.B., V.V.), University of California, San Francisco.; Department of Biochemistry and Biophysics (B.L.B.), University of California, San Francisco., Vedantham V; Cardiology Division (G.G., R.M., H.R., C.J., R.S.W., P.K.R.A., A.R., M.B.S., V.V.), University of California, San Francisco.; Cardiovascular Research Institute (T.S., R.S.W., B.L.B., V.V.), University of California, San Francisco.

Publikováno v: Circulation research [Circ Res] 2020 Dec 04; Vol. 127 (12), pp. 1502-1518. Date of Electronic Publication: 2020 Oct 12.