Zobrazeno 1 - 10 of 76 pro vyhledávání: '"Shh, Sonic Hedgehog"'
1
Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment
Autor: Xian Zeng, Dianwen Ju, Jiajun Fan, Yichen Wang, Jinghui Zhang, Jingyun Luan, Kai Yin, Mingming Nie
Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 609-620 (2021)
The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9591fe5f71a6d93ff75c586983adcb
https://doi.org/10.1016/j.apsb.2020.10.022
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2
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
Autor: Wenfu Tan, Huaqian Ding, Xiaohua Liu, Chunyong Ding, Juan Wang, Yalei Li, Ao Zhang, Yu Zhang, Hongchun Liu, Wenjing Huang
Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 488-504 (2021)
Acta Pharmaceutica Sinica. B
Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional fact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301cde2b3eb755a22e93dd5c8eb925b1
https://doi.org/10.1016/j.apsb.2020.07.007
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3
Modulation of Cancer-Associated Fibrotic Stroma by An Integrin αvβ3 Targeting Protein for Pancreatic Cancer Treatment
Autor: Zhi-Ren Liu, Jenny J. Yang, Malvika Sharma, Shiyuan Wang, Falguni Mishra, Sun Li, Ravi Chakra Turaga, Alyssa M. Krasinskas, Yi Yuan, Chunfeng Liu
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 161-179 (2021)
Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapeutics owing to dense fibrotic stroma orchestrated by cancer-associated pancreatic stellate cells (CAPaSC). CAPaSC also support cancer cell growth, metastasis, and r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8771aab570fac7daa58c9d33c3452dcd
http://europepmc.org/articles/PMC7674520
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4
Real-time sensing of MAPK signaling in medulloblastoma cells reveals cellular evasion mechanism counteracting dasatinib blockade of ERK activation during invasion
Autor: Alexandre Gries, Michael A. Grotzer, Anuja Neve, Marc Thomas Schönholzer, Min Ma, Karthiga Santhana Kumar, Martin Baumgartner, Jessica Migliavacca, Elena Alvarez
Publikováno v: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 470-483 (2020)
Highlights • Growth factor signaling causes sustained nuclear ERK1/2 activation. • The SCR and BCR/ABL inhibitor dasatinib blocks ERK1/2 and represses cell invasion. • EGF-stimulated cells may escape dasatinib inhibition of invasion through mes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a076863a1a0810fcffc300433bde15b
http://europepmc.org/articles/PMC7452206
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5
3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinoma
Autor: Xinyuan Liu, Rainer Heuchel, Jianping Liu, Anthony P. H. Wright, Gustav Arvidsson, Matthias Löhr, Beate Gündel, Xidan Li
Publikováno v: Translational Oncology
Translational Oncology, Vol 14, Iss 7, Pp 101107-(2021)
Highlights • We described a straightforward and highly reproducible 3D culturing method to investigate the intercellular crosstalk between pancreatic cancer and pancreatic stellate cells (PSCs)/cancer associated fibroblasts (CAFs). • Pancreatic d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309016806d03c6c70de0bb89b2ca621a
https://pubmed.ncbi.nlm.nih.gov/33946033
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6
BMI1 in the heart: Novel functions beyond tumorigenesis
Autor: Han-Qing Liu, Di Fan, Zheng Yang, Qi-Zhu Tang, Dan Yang
Publikováno v: EBioMedicine
EBioMedicine, Vol 63, Iss, Pp 103193-(2021)
The BMI1 protein, a member of the PRC1 family, is a well recognised transcriptional suppressor and has the capability of maintaining the self-renewal and proliferation of tissue-specific stem cells. Numerous studies have established that BMI1 is high
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a78fe900e8cee10a08a6793e74d9f3
http://europepmc.org/articles/PMC7804972
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7
GLI-fully Responsive to Inflammatory Cytokines
Autor: Spencer G. Willet
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1545-(2021)
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Helicobacter pylori infection in humans typically begins with colonization of the gastric antrum. The initial Th1 response occasionally coincides with an increase in gastrin secretion. Subsequently, the gastritis segues to chronic a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f457c49e2331471b01a166e62a2fe1
http://www.sciencedirect.com/science/article/pii/S2352345X21000345
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8
Incremental prognostic value and underlying biological pathways of radiomics patterns in medulloblastoma
Autor: Shenghai Zhang, Haibiao Zhao, Wenchao Duan, Tao Sun, Binke Yuan, Li Wang, Zhen-Yu Zhang, Xiangxiang Wang, Wencai Li, Dongling Pei, Xuanke Hong, Weiwei Wang, Chen Sun, Kay Ka-Wai Li, Yunbo Zhan, Zhen Liu, Wenqing Wang, Xianzhi Liu, Lei Liu, Jingliang Cheng, Yu Guo, Jing Yan, Ke Li, Zhicheng Li, Ho Keung Ng
Publikováno v: EBioMedicine, Vol 61, Iss, Pp 103093-(2020)
EBioMedicine
Background To develop a radiomics signature for predicting overall survival (OS)/progression-free survival (PFS) in patients with medulloblastoma (MB), and to investigate the incremental prognostic value and biological pathways of the radiomics patte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76b0f234deb5d8b243a900da89520c2
http://www.sciencedirect.com/science/article/pii/S2352396420304692
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9
New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors
Autor: Jianan Sun, Bo Wu, Dahong Li, Hui-Ming Hua, Bao Ji, Shanshan Luo, Fanxing Xu, Yan Xiao, Peng Wang, Chao Zheng, Keguang Cheng, Xu Hu
Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1148-1157 (2021)
As one of the most lethal diseases, pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities. Furthermore, pancreatic cancer escapes early detection during the curable period because early symptoms rarely em
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093ce424e4da05b4ed3727f0392f0661
https://pubmed.ncbi.nlm.nih.gov/34094825
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10
Not lost to follow-up: A rare case of CHILD syndrome in a boy reappears
Autor: Janellen Smith, Dong Joo Kim, Nathan Fackler, Hege Grande Sarpa, Cameron Zachary
Publikováno v: JAAD Case Reports
Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD) syndrome is an exceedingly rare, X-linked dominant genetic disorder of lipid metabolism that arises from mutations in NAD(P) dependent steroid dehydrogenase-like gene (NSDHL),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89ed1cc5ab8154fed8ff260736ffc47
https://doi.org/10.1016/j.jdcr.2018.10.001
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