Výsledky vyhledávání - "Shh, Sonic Hedgehog"

Hipospadias genetiğinde SHH (Sonic hedgehog) yolağının araştırılması

Autor: Yildiz, Şenay

ÖZETHipospadias, genital sistemin en sık görülen konjenital anomalilerinden biridir. Hipospadiasın potansiyel olarak bozulmuş gen ekspresyonları ile ilişkili olduğu gösterilmiş olsa da nedeni büyük ölçüde bilinmezliğini korumaktadır

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10208::11ea40257520f14abab56b6ab3fc8d77
https://acikbilim.yok.gov.tr/handle/20.500.12812/353698

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SHH (Sonic hedgehog)

Autor: T Magnaldo

Publikováno v: Atlas of Genetics and Cytogenetics in Oncology and Haematology.

Review on SHH (Sonic hedgehog), with data on DNA, on the protein encoded, and where the gene is implicated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72d1b6bdf0b95a6c3e2fba631eb23939
https://doi.org/10.4267/2042/37842

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Periodical

Localization of CD44 and CD90 positive cells to the invasive front of breast tumorsHow to cite this article: Donnenberg VS, Donnenberg AD, Zimmerlin L, Landreneau RJ, Bhargava R, Wetzel RA, Basse P, Brufsky AM. Localization of CD44 and CD90 positive cells to the invasive front of breast tumors. Cytometry Part B 2010; 78B: 287–301.PE phycoerythrin, PECy5 phycoerythrin cyanine 5, SHH sonic hedgehog, SSc side light scatter, UCI upper confidence intervalVera S. Donnenberg, Ph.D., and Albert D. Donnenberg, Ph.D., codesigned the experiments, analyzed the data, and cowrote the manuscript. Ludovic Zimmerlin, M.S., developed, validated, and performed immunofluorescent staining. Rodney J. Landreneau, M.D., and Adam M. Brufsky, M.D., provided clinical specimens and interpretation of therapy and clinical course. Rohit Bargava, M.D., prepared the tissue microarrays and reviewed immunohistostaining and histology. Per Basse, M.D., Ph.D., supervised the tumorigenicity experiments. Ryan Wetzel validate

Autor: Donnenberg, Vera S., Donnenberg, Albert D., Zimmerlin, Ludovic, Landreneau, Rodney J., Bhargava, Rohit, Wetzel, Ryan A., Basse, Per, Brufsky, Adam M.

Publikováno v: Cytometry Part B: Clinical Cytometry; September 2010, Vol. 78 Issue: 5 p287-301, 15p

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Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

Autor: Xian Zeng, Dianwen Ju, Jiajun Fan, Yichen Wang, Jinghui Zhang, Jingyun Luan, Kai Yin, Mingming Nie

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 609-620 (2021)

The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9591fe5f71a6d93ff75c586983adcb
https://doi.org/10.1016/j.apsb.2020.10.022

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Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

Autor: Wenfu Tan, Huaqian Ding, Xiaohua Liu, Chunyong Ding, Juan Wang, Yalei Li, Ao Zhang, Yu Zhang, Hongchun Liu, Wenjing Huang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 488-504 (2021)
Acta Pharmaceutica Sinica. B

Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301cde2b3eb755a22e93dd5c8eb925b1
https://doi.org/10.1016/j.apsb.2020.07.007

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Modulation of Cancer-Associated Fibrotic Stroma by An Integrin αvβ3 Targeting Protein for Pancreatic Cancer Treatment

Autor: Zhi-Ren Liu, Jenny J. Yang, Malvika Sharma, Shiyuan Wang, Falguni Mishra, Sun Li, Ravi Chakra Turaga, Alyssa M. Krasinskas, Yi Yuan, Chunfeng Liu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 161-179 (2021)

Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapeutics owing to dense fibrotic stroma orchestrated by cancer-associated pancreatic stellate cells (CAPaSC). CAPaSC also support cancer cell growth, metastasis, and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8771aab570fac7daa58c9d33c3452dcd
http://europepmc.org/articles/PMC7674520

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Real-time sensing of MAPK signaling in medulloblastoma cells reveals cellular evasion mechanism counteracting dasatinib blockade of ERK activation during invasion

Autor: Alexandre Gries, Michael A. Grotzer, Anuja Neve, Marc Thomas Schönholzer, Min Ma, Karthiga Santhana Kumar, Martin Baumgartner, Jessica Migliavacca, Elena Alvarez

Publikováno v: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 470-483 (2020)

Highlights • Growth factor signaling causes sustained nuclear ERK1/2 activation. • The SCR and BCR/ABL inhibitor dasatinib blocks ERK1/2 and represses cell invasion. • EGF-stimulated cells may escape dasatinib inhibition of invasion through mes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a076863a1a0810fcffc300433bde15b
http://europepmc.org/articles/PMC7452206

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Akademický článek

The SHH‐GLI1 pathway is required in skin expansion and angiogenesis.

Autor: Zhang, Xinling^1,2,3 (AUTHOR), Chen, Yujie³ (AUTHOR), Ding, Pengbing³ (AUTHOR), Lin, Zhiyu³ (AUTHOR), Sun, Zhixuan³ (AUTHOR), Jin, Mengying³ (AUTHOR), Li, Chong⁴ (AUTHOR), Zhao, Zhenmin³ (AUTHOR) zhaozhenmin0098@vip.sina.com, Bi, Hongsen³ (AUTHOR) bihongsen@bjmu.edu.cn

Publikováno v: Experimental Dermatology. Jul2023, Vol. 32 Issue 7, p1085-1095. 11p.

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3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinoma

Autor: Xinyuan Liu, Rainer Heuchel, Jianping Liu, Anthony P. H. Wright, Gustav Arvidsson, Matthias Löhr, Beate Gündel, Xidan Li

Publikováno v: Translational Oncology
Translational Oncology, Vol 14, Iss 7, Pp 101107-(2021)

Highlights • We described a straightforward and highly reproducible 3D culturing method to investigate the intercellular crosstalk between pancreatic cancer and pancreatic stellate cells (PSCs)/cancer associated fibroblasts (CAFs). • Pancreatic d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309016806d03c6c70de0bb89b2ca621a
https://pubmed.ncbi.nlm.nih.gov/33946033

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BMI1 in the heart: Novel functions beyond tumorigenesis

Autor: Han-Qing Liu, Di Fan, Zheng Yang, Qi-Zhu Tang, Dan Yang

Publikováno v: EBioMedicine
EBioMedicine, Vol 63, Iss, Pp 103193-(2021)

The BMI1 protein, a member of the PRC1 family, is a well recognised transcriptional suppressor and has the capability of maintaining the self-renewal and proliferation of tissue-specific stem cells. Numerous studies have established that BMI1 is high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a78fe900e8cee10a08a6793e74d9f3
http://europepmc.org/articles/PMC7804972

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