Zobrazeno 1 - 10
of 5 071
pro vyhledávání: '"Shh"'
Autor:
Foteini Tsiami, Chiara Lago, Noemi Pozza, Federica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E. Root, Luca Tiberi, Marcel Kool, Jens Schittenhelm, Pratiti Bandopadhayay, Rosalind A. Segal, Ghazaleh Tabatabai, Daniel J. Merk
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract Sonic hedgehog subgroup of medulloblastoma (SHH-MB) is characterized by aberrant activation of the SHH signaling pathway. An inhibition of the positive SHH regulator Smoothened (SMO) has demonstrated promising clinical efficacy. Yet, primary
Externí odkaz:
https://doaj.org/article/1081383d8a884e1bb850b117fd782524
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract A cell is a dynamic system in which various processes occur simultaneously. In particular, intra- and intercellular signaling pathway crosstalk has a significant impact on a cell’s life cycle, differentiation, proliferation, growth, regene
Externí odkaz:
https://doaj.org/article/2d340989e280417097e1831c73a30542
Autor:
Md. Mizanur Rahman, Muhammad Mosaraf Hossain, Shafiqul Islam, Ridwan Ahmed, Mohit Majumder, Shantu Dey, Md. Kawser, Bishu Sarkar, Md. Ejajur Rahman Himu, Ali Asgar Chowdhury, Shakera Ahmed, Supran Biswas, Mostafa Mahfuzul Anwar, Mohammad Jamal Hussain, Rajib Kumar Shil, Sunanda Baidya, Ramendu Parial, Mohammed Moinul Islam, Atul Bharde, Sreeja Jayant, Gourishankar Aland, Jayant Khandare, Shaikh Bokhtear Uddin, Abu Shadat Mohammod Noman
Publikováno v:
BMC Molecular and Cell Biology, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background The lack of appropriate prognostic biomarkers remains a significant obstacle in the early detection of Head and Neck Squamous Cell Carcinoma (HNSCC), a cancer type with a high mortality rate. Despite considerable advancements in t
Externí odkaz:
https://doaj.org/article/f6c73da16a9342249ea788de13ecfd17
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Circulating platelets derived from bone marrow megakaryocytes play a central role in thrombosis and hemostasis. Despite being anucleate, platelets express several proteins known to have nuclear niche. These include transcription factors and
Externí odkaz:
https://doaj.org/article/eb8488161e2a4c358d1f5d11100e0272
Autor:
Jana Goida, Mara Pilmane
Publikováno v:
Maxillofacial Plastic and Reconstructive Surgery, Vol 46, Iss 1, Pp 1-13 (2024)
Abstract Background Worldwide cleft lip with or without a cleft palate (CL/P) is the most common craniofacial birth defect. Apart from changes in facial appearance, additionally affected individuals often suffer from various associated comorbidities
Externí odkaz:
https://doaj.org/article/d2f558ea63b14d72857f599ca799bbb1
Publikováno v:
Acta Medica Lituanica, Vol 31, Iss 1 (2024)
Congenital abdominal adhesions are a rare condition that can result in a small bowel obstruction at any age, more frequently in pediatric populations. The cause remains unknown, and the importance of aberrant congenital bands is related to the diffic
Externí odkaz:
https://doaj.org/article/52d0a6cf5a46462a930bb55963a53f49
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 276, Iss , Pp 116311- (2024)
Prenatal environmental exposure could be an essential health risk factor associated with neurodevelopmental disorders in offspring. However, the exact mechanisms underlying the impact of prenatal PM2.5 exposure on offspring cognition remain unclear.
Externí odkaz:
https://doaj.org/article/f3e48e725fe54455a47c398d1eceaacb
Autor:
Ying Li, Weihong Xue, Songyi Li, Lili Cui, Yuxiao Gao, Linlin Li, Rong Chen, Xiao Zhang, Renhao Xu, Wei Jiang, Xiangjian Zhang, Lina Wang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116625- (2024)
Aims: The purpose of this study was to explore the impacts of salidroside on vascular regeneration, vascular structural changes and long-term neurological recuperation following cerebral ischemia and its possible mechanism. Main methods: From Day 1 t
Externí odkaz:
https://doaj.org/article/d2f0e609583c4ef1872af002b229f103
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116503- (2024)
Androgenetic alopecia (AGA) is a prevalent disease in worldwide, local application or oral are often used to treat AGA, however, effective treatments for AGA are currently limited. In this work, we observed the promoting the initial anagen phase effe
Externí odkaz:
https://doaj.org/article/63e3100777024d2098393a446398b466
Publikováno v:
Biomedical Journal, Vol 47, Iss 2, Pp 100627- (2024)
Background: This study aimed to investigate the effect of LAMA5 on palatal development in mice. Methods: The palatine process of C57BL/6 J fetal mice on the embryonic day 13.5 (E13.5) was cultured in vitro via the rotating culture method. The LAMA5-s
Externí odkaz:
https://doaj.org/article/1d5a191824f6452b9bb599b1acc42a4d