Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sheyenne Carette"'
Autor:
Robert Siddaway, Laura Canty, Sanja Pajovic, Scott Milos, Etienne Coyaud, Stefanie-Grace Sbergio, Arun Kumaran Vadivel Anguraj, Evan Lubanszky, Hwa Young Yun, Alessia Portante, Sheyenne Carette, Cunjie Zhang, Michael F. Moran, Brian Raught, Eric I. Campos, Cynthia Hawkins
Publikováno v:
Acta Neuropathologica. 144:1027-1048
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition, while H3G34R mutations
Autor:
Etienne Coyaud, Sheyenne Carette, Haley Yun, Stefanie-Grace Sbergio, Sanja Pajovic, Robert Siddaway, Cynthia Hawkins, Scott Milos, Laura Canty, Alessia Portante, Brian Raught, Eric Campos, Evan Lubanszky
Publikováno v:
Neuro Oncol
Mutations in histone H3 at amino acids 27 (H3K27M) and 34 (H3G34R) occur with high-frequency in pediatric high-grade glioma. H3K27M mutations have been shown to lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition with acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4539177c8f68a138cd55721de1cb0071
https://europepmc.org/articles/PMC8598539/
https://europepmc.org/articles/PMC8598539/
Autor:
Stefanie-Grace Sbergio, Javal Sheth, Laura Canty, Sanja Pajovic, Arun Anguraj Vadivel, Sheyenne Carette, Robert Siddaway, Cynthia Hawkins
Publikováno v:
Neuro-Oncology. 24:vii210-vii210
Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brain tumor. The mean age of onset is 7-9 years with a median survival of 9 months following diagnosis. Histone 3 (H3) mutations (H3K27M) have been identified in approximately 80% of