Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sheyda Azimi"'
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen which causes chronic, drug-resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of genomic diversification and evolutionary trade-offs in antimicro
Externí odkaz:
https://doaj.org/article/7b74583486714893a47a6b6a5f636bb8
Autor:
Sheyda Azimi, Jacob Thomas, Sara E. Cleland, Jennifer E. Curtis, Joanna B. Goldberg, Stephen P. Diggle
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Bacteria live in spatially organized aggregates during chronic infections, where they adapt to the host environment, evade immune responses, and resist therapeutic interventions. Although it is known that environmental factors such as polyme
Externí odkaz:
https://doaj.org/article/af1ea9cac38f4baf917914f59eb4b5b5
Autor:
Amanda P. Henry, Kelly Probert, Ceri E. Stewart, Dhruma Thakker, Sangita Bhaker, Sheyda Azimi, Ian P. Hall, Ian Sayers
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a candidate causal gene in this l
Externí odkaz:
https://doaj.org/article/45b95aff7d3b48fb89b56781600c8437
Autor:
Bo Liu, Amanda P Henry, Sheyda Azimi, Suzanne Miller, Frank K Lee, Jane C Lee, Kelly Probert, Michael I Kotlikoff, Ian Sayers, Ian P Hall
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221899 (2019)
IntroductionGenome-Wide Association Studies suggest glutathione S transferase C terminal domain (GSTCD) may play a role in development of Chronic Obstructive Pulmonary Disease. We aimed to define the potential role of GSTCD in airway inflammation and
Externí odkaz:
https://doaj.org/article/ec8d27b6cfac44e880f6ab3ddd84cfa7
Autor:
Jafar Mahdavi, Pierre-Joseph Royer, Hong S. Sjölinder, Sheyda Azimi, Tim Self, Jeroen Stoof, Lee M. Wheldon, Kristoffer Brännström, Raymond Wilson, Joanna Moreton, James W. B. Moir, Carina Sihlbom, Thomas Borén, Ann-Beth Jonsson, Panos Soultanas, Dlawer A. A. Ala'Aldeen
Publikováno v:
Open Biology, Vol 3, Iss 10 (2013)
Interactions between commensal pathogens and hosts are critical for disease development but the underlying mechanisms for switching between the commensal and virulent states are unknown. We show that the human pathogen Neisseria meningitidis, the lea
Externí odkaz:
https://doaj.org/article/0922dc73be34404db1e8d80e0eb1dffe
Publikováno v:
Nat Rev Microbiol
Many microbial communities, including those involved in chronic human infections, are patterned at the micron scale. In this Review, we summarize recent work that has defined the spatial arrangement of microorganisms in infection and begun to demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a7116fdb49ab9fd5ff6fd7c593db64
https://pubmed.ncbi.nlm.nih.gov/35136217
https://pubmed.ncbi.nlm.nih.gov/35136217
Autor:
Joanna B. Goldberg, Stephen P. Diggle, Sara E. Cleland, Jennifer E. Curtis, Jacob Thomas, Sheyda Azimi
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
mBio
mBio
Bacteria live in spatially organized aggregates during chronic infections, where they adapt to the host environment, evade immune responses and resist therapeutic interventions. Although it is known that environmental factors such as polymers influen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2913e662d1a016bfd47afe48ad21e843
https://doi.org/10.1128/mbio.00860-21
https://doi.org/10.1128/mbio.00860-21
SummaryNeisseria meningitidisremains an important cause of human disease. It is highly adapted to the human host – its only known reservoir. Adaptations to the host environment include many specific interactions with human molecules including iron-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f409d9b38dc94facb0de009d31bdeef9
Autor:
Urvish Trivedi, Jelly Vanderwoude, Derek Fleming, Stephen P. Diggle, Kendra P. Rumbaugh, Sheyda Azimi
Publikováno v:
Proc Biol Sci
Vanderwoude, J, Fleming, D, Azimi, S, Trivedi, U, Rumbaugh, K P & Diggle, S P 2020, ' The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection ', Proceedings of the Royal Society B: Biological Sciences, vol. 287, no. 1937, 20202272 . https://doi.org/10.1098/rspb.2020.2272
Vanderwoude, J, Fleming, D, Azimi, S, Trivedi, U, Rumbaugh, K P & Diggle, S P 2020, ' The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection ', Proceedings of the Royal Society B: Biological Sciences, vol. 287, no. 1937, 20202272 . https://doi.org/10.1098/rspb.2020.2272
Opportunistic pathogens are associated with several widespread, recalcitrant chronic infections in humans. As the pipeline for new antibiotics thins, virulence management presents an alternative solution to the rising antimicrobial resistance crisis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1b785a948feb1711b2f2cb7e6ccdf6
https://europepmc.org/articles/PMC7661302/
https://europepmc.org/articles/PMC7661302/