Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shewan M. Aziz"'
Autor:
Shewan M. Aziz, Mark Bowers, Manni Yegappan, Ronald D. Brown, Satya Ramachandran, Neeraj Sharma, Robert Chapman, Bennett W. Yu
Publikováno v:
Cancer Chemotherapy and Pharmacology. 46:329-337
Purpose: To determine factors which influence the sensitivity of human colorectal carcinoma cell lines to paclitaxel. Methods: The paclitaxel sensitivity of ten human colorectal carcinoma cell lines, and a panel of RKO colon carcinoma cell lines, iso
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 17:307-320
The use of a combination of monofluorescein adducts of spermidine (FL-SPD) and spermine (FL-SPM) with confocal laser scanning microscopy (CLSM) provides a useful means for monitoring the fate and time-dependent changes in the distribution of transpor
Publikováno v:
Cell Biology International. 21:801-812
Alterations in polyamine metabolism may be a critical mechanism of monocrotaline (MCT)-induced structural remodeling of the pulmonary vasculature. In the present study, the hypothesis that MCT, through the induction of oxidative stress, modulates cel
Autor:
Bernhard Hennig, Shewan M. Aziz, Mark P. Mattson, Michal Toborek, David W. Lipke, Hongtao Guo
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 29:775-787
Oxidative stress may be involved in monocrotaline (MCT)-induced endothelial cell injury and upregulation of extracellular matrix proteins in the pulmonary vasculature. To test this hypothesis, cytotoxicity, expression and distribution of tenascin (TN
Publikováno v:
Clinical and Experimental Hypertension. 19:297-312
This study examined the temporal effects of the polyamine synthesis inhibitor eflornithine (alpha-difluoromethylornithine) on vascular responses to KCI, norepinephrine, sodium nitroprusside and acetylcholine in aortic rings from coarctation hypertens
Autor:
Mark N. Gillespie, Shewan M. Aziz, Anjili C. Vyas-Somani, Jack W. Olson, David W. Lipke, Santosh A. Arcot
Publikováno v:
The American Journal of the Medical Sciences. 312:54-67
The hypoxic model of pulmonary hypertension was used to examine temporal alterations in the deposition of the basement membrane (BM) and components of fibronectin, laminin, and Type IV collagen within vascular, airway, and gas exchange compartments o
Autor:
Shewan M. Aziz, Michael J. Buckmaster, Eric D. Endean, Gloria Gellin, Boulos Toursarkissian, Brad Hill
Publikováno v:
Growth Factors. 13:229-242
Basic-FGF (FGF2) is implicated as a regulator of smooth muscle cell proliferation that develops after arterial injury. Polyamines are essential for cell growth and differentiation and may mediate some of the FGF2-elicited responses. To examine this p
Publikováno v:
Pharmaceutical Research. 12:1658-1663
Purpose. The purpose of this study is to investigate the interaction of cationic polyamino acids, polylysine and polyarginine, with rat pulmonary surfactant at the air/water interface.
Publikováno v:
Journal of Surgical Research. 57:401-407
Increased arterial wall polyamine content has been linked to intimal hyperplasia (IH) formation. Intracellular polyamine content may be regulated by a polyamine transmembrane transport mechanism, but the existence of such a system has not been demons
Publikováno v:
Pediatric Research. 34:32-37
The lung appears to be one of the dominant sites of bacterial clearance from the blood of infant piglets. Part of the lung bacterial clearance involves activation of an oxygen radical bactericidal mechanism that may be central to induction of acute p