The investigation of structure-activity relationship of polyamine-targeted synthetic compounds from different chemical groups.

Autor: Syatkin SP; Medical Institute, RUDN University (Peoples' Friendship University of Russia), Miklukho-Maklaya str.6, Moscow, 117198, Russia. syatkin_sp@pfur.ru., Neborak EV; Medical Institute, RUDN University (Peoples' Friendship University of Russia), Miklukho-Maklaya str.6, Moscow, 117198, Russia., Khlebnikov AI; Kizhner Research Center, National Research Tomsk Polytechnic University, Tomsk, 634050, Russia.; Scientific Research Institute of Biological Medicine, Altai State University, Barnaul, 656049, Russia., Komarova MV; Samara University, Moskovskoye shosse, 34, Samara, 443086, Russia., Shevkun NA; Drug Product Division, Project Development Department, NEARMEDIC PHARMA LLC, Moscow, Russia., Kravtsov EG; Medical Institute, RUDN University (Peoples' Friendship University of Russia), Miklukho-Maklaya str.6, Moscow, 117198, Russia., Blagonravov ML; Medical Institute, RUDN University (Peoples' Friendship University of Russia), Miklukho-Maklaya str.6, Moscow, 117198, Russia., Agostinelli E; Department of Biochemical Sciences, SAPIENZA University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.; International Polyamines Foundation, ONLUS, Via del Forte Tiburtino, 98, 00159, Rome, Italy.

Publikováno v: Amino acids [Amino Acids] 2020 Feb; Vol. 52 (2), pp. 199-211. Date of Electronic Publication: 2019 Sep 13.

Design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists.

Autor: Ivachtchenko AV; Alla Chem LLC, 1835 East Hallandale Beach Boulevard 442, Hallandale Beach, FL 33009, United States; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia; ChemDiv, 6605 Nancy Ridge Drive, San Diego, CF 92121, USA., Ivanenkov YA; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia; ChemDiv, 6605 Nancy Ridge Drive, San Diego, CF 92121, USA; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region 141700, Russia; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow 119991, Russia. Electronic address: yai@chemdiv.com., Mitkin OD; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Vorobiev AA; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Kuznetsova IV; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Shevkun NA; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Koryakova AG; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Karapetian RN; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Trifelenkov AS; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Kravchenko DV; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Veselov MS; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region 141700, Russia; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow 119991, Russia., Chufarova NV; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region 141700, Russia.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2015 Jun 24; Vol. 99, pp. 51-66. Date of Electronic Publication: 2015 Jun 02.

Novel oral anti-influenza drug candidate AV5080.

Autor: Ivachtchenko AV; ASAVI LLC, Hallandale Beach, FL, USA Chemical Diversity Research Institute, Khimki, Moscow Reg., Russia ChemDiv, San Diego, CA, USA av@asavillc.com., Ivanenkov YA; Chemical Diversity Research Institute, Khimki, Moscow Reg., Russia ChemDiv, San Diego, CA, USA The Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Reg., Russia., Mitkin OD; Chemical Diversity Research Institute, Khimki, Moscow Reg., Russia., Yamanushkin PM; Chemical Diversity Research Institute, Khimki, Moscow Reg., Russia., Bichko VV; ChemDiv, San Diego, CA, USA., Shevkun NA; Chemical Diversity Research Institute, Khimki, Moscow Reg., Russia., Karapetian RN; Chemical Diversity Research Institute, Khimki, Moscow Reg., Russia., Leneva IA; I. Mechnikov Research Institute of Vaccines and Sera of Russian Academy of Medical Science, Moscow, Russia., Borisova OV; I. Mechnikov Research Institute of Vaccines and Sera of Russian Academy of Medical Science, Moscow, Russia., Veselov MS; The Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Reg., Russia.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2014 Jul; Vol. 69 (7), pp. 1892-902. Date of Electronic Publication: 2014 Apr 11.

Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment.

Autor: Ivachtchenko AV; 1. ChemDiv Inc., 6605 Nancy Ridge Drive, San Diego, CA 92121, USA ; 2. Chemical Diversity Research Institute, 141401 Khimki, Rabochaya str, 2a-1, Moscow Reg, Russia ; 3. Alla Chem LLC., 1835 E. Hallandale Beach Blvd, #442, Hallandale Beach, FL 33009, USA., Mitkin OD; 2. Chemical Diversity Research Institute, 141401 Khimki, Rabochaya str, 2a-1, Moscow Reg, Russia., Kudan EV; 2. Chemical Diversity Research Institute, 141401 Khimki, Rabochaya str, 2a-1, Moscow Reg, Russia., Rjahovsky AA; 2. Chemical Diversity Research Institute, 141401 Khimki, Rabochaya str, 2a-1, Moscow Reg, Russia., Vorobiev AA; 2. Chemical Diversity Research Institute, 141401 Khimki, Rabochaya str, 2a-1, Moscow Reg, Russia., Trifelenkov AS; 2. Chemical Diversity Research Institute, 141401 Khimki, Rabochaya str, 2a-1, Moscow Reg, Russia., Shevkun NA; 2. Chemical Diversity Research Institute, 141401 Khimki, Rabochaya str, 2a-1, Moscow Reg, Russia., Proskurina OV; 2. Chemical Diversity Research Institute, 141401 Khimki, Rabochaya str, 2a-1, Moscow Reg, Russia., Kravchenko DV; 2. Chemical Diversity Research Institute, 141401 Khimki, Rabochaya str, 2a-1, Moscow Reg, Russia., Karapetian RN; 2. Chemical Diversity Research Institute, 141401 Khimki, Rabochaya str, 2a-1, Moscow Reg, Russia.

Publikováno v: Journal of Cancer [J Cancer] 2014 Jan 21; Vol. 5 (2), pp. 133-42. Date of Electronic Publication: 2014 Jan 21 (Print Publication: 2014).

[Preclinical study of AV0012 early stage inhibitor of hepatitis C virus infection: I. In vitro ADME and pharmacokinetics].

Autor: Ivashchenko AV, Iamanushkin PM, Mit'kin OD, Ezhova EV, Korzinov OM, Shevkun NA, Koriakova AG, Karapetian RN, Bychko VV, Ivashchenko AA, Agrba VZ, Lapin BA, Orlov SV

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2014; Vol. 77 (4), pp. 33-41.