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Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts.

Autor: Chun H; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Kurasawa JH; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Olivares P; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Marakasova ES; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Shestopal SA; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Hassink GU; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Karnaukhova E; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Migliorini M; Center for Vascular and Inflammatory Diseases, Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Obi JO; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA., Smith AK; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA., Wintrode PL; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA., Durai P; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, Republic of Korea., Park K; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, Republic of Korea., Deredge D; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA., Strickland DK; Center for Vascular and Inflammatory Diseases, Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sarafanov AG; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2022 Oct; Vol. 20 (10), pp. 2255-2269. Date of Electronic Publication: 2022 Aug 04.