Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Sheryl S Moy"'
Autor:
Julie C Necarsulmer, Jeremy M Simon, Baggio A Evangelista, Youjun Chen, Xu Tian, Sara Nafees, Ariana B Marquez, Huijun Jiang, Ping Wang, Deepa Ajit, Viktoriya D Nikolova, Kathryn M Harper, J Ashley Ezzell, Feng-Chang Lin, Adriana S Beltran, Sheryl S Moy, Todd J Cohen
Publikováno v:
eLife, Vol 12 (2023)
TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic acid-binding protein TDP-43 and subseque
Externí odkaz:
https://doaj.org/article/1ef60b65b631406abd7b36cb7384d395
Autor:
Kelsey A Behrens, Leigh A Jania, John N Snouwaert, MyTrang Nguyen, Sheryl S Moy, Andrey P Tikunov, Jeffrey M Macdonald, Beverly H Koller
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225449 (2019)
Environmental and endogenous electrophiles cause tissue damage through their high reactivity with endogenous nucleophiles such as DNA, proteins, and lipids. Protection against damage is mediated by glutathione (GSH) conjugation, which can occur spont
Externí odkaz:
https://doaj.org/article/3bfefc70a31c4aed8966846980f44286
Autor:
Julia S. Lord, Sean M. Gay, Kathryn M. Harper, Viktoriya D. Nikolova, Kirsten M. Smith, Sheryl S. Moy, Graham H. Diering
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-19 (2022)
Abstract Background Patients with autism spectrum disorder (ASD) experience high rates of sleep disruption beginning early in life; however, the developmental consequences of this disruption are not understood. We examined sleep behavior and the cons
Externí odkaz:
https://doaj.org/article/c5e745d47c3941baa4b107535e8ce93b
Autor:
Jessica A. Jiménez, Jeremy M. Simon, Wenxin Hu, Sheryl S. Moy, Kathryn M. Harper, Chih-Wei Liu, Kun Lu, Mark J. Zylka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Hundreds of genes have been associated with autism spectrum disorder (ASD), including loss-of-function mutations in chromodomain helicase DNA binding protein 8 (Chd8). Environmental factors also are implicated in autism risk and have the pot
Externí odkaz:
https://doaj.org/article/04768033bf0245a198afb592fc2b8afe
Autor:
Jessica A. Jiménez, Travis S. Ptacek, Alex H. Tuttle, Ralf S. Schmid, Sheryl S. Moy, Jeremy M. Simon, Mark J. Zylka
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-15 (2020)
Abstract Background Chromodomain helicase DNA-binding protein 8 (Chd8) is a high-confidence risk gene for autism spectrum disorder (ASD). However, how Chd8 haploinsufficiency impairs gene expression in the brain and impacts behavior at different stag
Externí odkaz:
https://doaj.org/article/ad6f601c36c849359209184c163a9e8d
Autor:
Chunping Qiao, Yi Dai, Viktoriya D. Nikolova, Quan Jin, Jianbin Li, Bin Xiao, Juan Li, Sheryl S. Moy, Xiao Xiao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 47-56 (2018)
LAMA2-related muscular dystrophy (LAMA2 MD) is the most common and fatal form of early-onset congenital muscular dystrophies. Due to the large size of the laminin α2 cDNA and heterotrimeric structure of the protein, it is challenging to develop a ge
Externí odkaz:
https://doaj.org/article/6a279e4c8d194810bc744e9f65427a32
Autor:
R. Oliver Goral, Kathryn M. Harper, Briana J. Bernstein, Sydney A. Fry, Patricia W. Lamb, Sheryl S. Moy, Jesse D. Cushman, Jerrel L. Yakel
Publikováno v:
Frontiers in Behavioral Neuroscience. 16
Introduction: Altered signaling or function of acetylcholine (ACh) has been reported in various neurological diseases, including Alzheimer’s disease, Tourette syndrome, epilepsy among others. Many neurons that release ACh also co-transmit the neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a03ed7961535aa6e6d74a45603505e
https://doi.org/10.3389/fnbeh.2022.1067409
https://doi.org/10.3389/fnbeh.2022.1067409
Publikováno v:
Methods in Molecular Biology ISBN: 9781071627518
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44790c896a16c53de4ff0af2234b18bc
https://doi.org/10.1007/978-1-0716-2752-5_14
https://doi.org/10.1007/978-1-0716-2752-5_14
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2583
Behavioral phenotyping approaches for neonatal mice are important for investigating early alterations in brain development and function, relevant to neurodevelopmental disorders in humans. This chapter describes a behavioral screen that can provide a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab8d1807816a71edeff2d99c657faa66
https://pubmed.ncbi.nlm.nih.gov/36418733
https://pubmed.ncbi.nlm.nih.gov/36418733
Autor:
Ashutosh Tripathy, Deepa Ajit, Natallia V. Riddick, John Q. Trojanowski, Michelle S. Itano, Sheryl S. Moy, Hanna Trzeciakiewicz, Todd J. Cohen, Zarin Tabassum, Youjun Chen, Claire Peterson, Rebecca Lobrovich, Jui-Heng Tseng, Aditi Ajit, Virginia M.-Y. Lee, David J. Irwin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Tauopathies including Alzheimer’s disease (AD) are marked by the accumulation of aberrantly modified tau proteins. Acetylated tau, in particular, has recently been implicated in neurodegeneration and cognitive decline. HDAC6 reversibly regulates ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd10a6c5e8f3d302f740aa43d104675
http://link.springer.com/article/10.1038/s41467-020-19317-4
http://link.springer.com/article/10.1038/s41467-020-19317-4